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    Matcap2 microtubule associated tyrosine carboxypeptidase 2 [ Mus musculus (house mouse) ]

    Gene ID: 68283, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Matcap2provided by MGI
    Official Full Name
    microtubule associated tyrosine carboxypeptidase 2provided by MGI
    Primary source
    MGI:MGI:1915533
    See related
    Ensembl:ENSMUSG00000036411 AllianceGenome:MGI:1915533
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0895; 1110003N12Rik; 9530077C05Rik
    Summary
    Is expressed in several structures, including central nervous system; endocrine gland; gut; male reproductive gland or organ; and respiratory system. Orthologous to human KIAA0895 (KIAA0895). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 8.7), CNS E18 (RPKM 1.8) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 A3; 9 9.14 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (22299849..22355980)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (22388559..22444684)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_23543 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene Neighboring gene 40S ribosomal protein S20 pseudogene Neighboring gene STARR-seq mESC enhancer starr_23549 Neighboring gene anillin, actin binding protein Neighboring gene STARR-positive B cell enhancer ABC_E2286 Neighboring gene STARR-seq mESC enhancer starr_23553 Neighboring gene STARR-seq mESC enhancer starr_23554 Neighboring gene STARR-positive B cell enhancer ABC_E5056 Neighboring gene retinitis pigmentosa 9 (human) Neighboring gene ribosomal protein L7A pseudogene Neighboring gene Bardet-Biedl syndrome 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Tissue expression patterns identify mouse cilia genes. McClintock TS, et al. Physiol Genomics, 2008 Jan 17. PMID 17971504
    2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • KIAA0895

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    putative tyrosine carboxypeptidase MATCAP2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001378982.1 → NP_001365911.1  putative tyrosine carboxypeptidase MATCAP2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), as well as variant 5, encodes isoform b.
      Source sequence(s)
      AC093926
      Conserved Domains (1) summary
      cl06858
      Location:77 → 418
      DUF1704; Domain of unknown function (DUF1704)

    2. NM_001378983.1 → NP_001365912.1  putative tyrosine carboxypeptidase MATCAP2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variant 4, encodes isoform b.
      Source sequence(s)
      AC093926
      Conserved Domains (1) summary
      cl06858
      Location:77 → 418
      DUF1704; Domain of unknown function (DUF1704)

    3. NM_026739.3 → NP_081015.1  putative tyrosine carboxypeptidase MATCAP2 isoform a

      See identical proteins and their annotated locations for NP_081015.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AC093926
      Consensus CDS
      CCDS40563.1
      UniProtKB/Swiss-Prot
      Q5DU11, Q7TQE7, Q80V66, Q9CTJ2
      Related
      ENSMUSP00000062120.8, ENSMUST00000058868.9
      Conserved Domains (1) summary
      cl06858
      Location:177 → 518
      DUF1704; Domain of unknown function (DUF1704)

    RNA

    1. NR_152381.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC093926
      Related
      ENSMUST00000213598.2

    2. NR_152382.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC093926

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      22299849..22355980
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510573.2 → XP_006510636.1  putative tyrosine carboxypeptidase MATCAP2 isoform X5

      See identical proteins and their annotated locations for XP_006510636.1

      UniProtKB/Swiss-Prot
      Q7TQE7
      Conserved Domains (1) summary
      cl06858
      Location:43 → 235
      DUF1704; Domain of unknown function (DUF1704)

    2. XM_036155226.1 → XP_036011119.1  putative tyrosine carboxypeptidase MATCAP2 isoform X4

      Conserved Domains (1) summary
      cl06858
      Location:107 → 299
      DUF1704; Domain of unknown function (DUF1704)

    3. XM_006510568.5 → XP_006510631.2  putative tyrosine carboxypeptidase MATCAP2 isoform X2

      Conserved Domains (1) summary
      cl06858
      Location:313 → 588
      DUF1704; Domain of unknown function (DUF1704)

    4. XM_011242589.3 → XP_011240891.2  putative tyrosine carboxypeptidase MATCAP2 isoform X3

      Conserved Domains (1) summary
      cl06858
      Location:180 → 455
      DUF1704; Domain of unknown function (DUF1704)

    5. XM_036155225.1 → XP_036011118.1  putative tyrosine carboxypeptidase MATCAP2 isoform X1

      Conserved Domains (1) summary
      cl06858
      Location:325 → 513
      DUF1704; Domain of unknown function (DUF1704)

    6. XM_011242592.2 → XP_011240894.1  putative tyrosine carboxypeptidase MATCAP2 isoform X5

      See identical proteins and their annotated locations for XP_011240894.1

      UniProtKB/Swiss-Prot
      Q7TQE7
      Related
      ENSMUST00000213133.2
      Conserved Domains (1) summary
      cl06858
      Location:43 → 235
      DUF1704; Domain of unknown function (DUF1704)

    7. XM_017313548.1 → XP_017169037.1  putative tyrosine carboxypeptidase MATCAP2 isoform X5

      UniProtKB/Swiss-Prot
      Q7TQE7
      Conserved Domains (1) summary
      cl06858
      Location:43 → 235
      DUF1704; Domain of unknown function (DUF1704)

    RNA

    1. XR_004935540.1 RNA Sequence

    2. XR_001779003.3 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_183273.1: Suppressed sequence

      Description
      NM_183273.1: This RefSeq has been removed because currently there is not sufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TQE7.2 GenPept UniProtKB/Swiss-Prot:Q7TQE7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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