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    Slc5a6 solute carrier family 5 member 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170551, updated on 2-May-2024

    Summary

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    Official Symbol
    Slc5a6provided by RGD
    Official Full Name
    solute carrier family 5 member 6provided by RGD
    Primary source
    RGD:69648
    See related
    Ensembl:ENSRNOG00000057628 AllianceGenome:RGD:69648
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    SMVT
    Summary
    Enables sodium-dependent multivitamin transmembrane transporter activity. Involved in biotin transport and pantothenate transmembrane transport. Located in brush border membrane and vesicle membrane. Orthologous to human SLC5A6 (solute carrier family 5 member 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 226.9), Adrenal (RPKM 189.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    6q14
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (31039865..31051671)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (25319187..25331713)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (26685823..26697110)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase Neighboring gene all-trans retinoic acid-induced differentiation factor Neighboring gene transcription factor 23 Neighboring gene proline rich 30

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Comparative analysis of ontogenic changes in renal and intestinal biotin transport in the rat. Nabokina SM, et al. Am J Physiol Renal Physiol, 2003 Apr. PMID 12620923
    2. Molecular characterization of the 5' regulatory region of rat sodium-dependent multivitamin transporter gene. Chatterjee NS, et al. Am J Physiol Cell Physiol, 2001 Mar. PMID 11171574
    3. Molecular mechanism of the intestinal biotin transport process. Chatterjee NS, et al. Am J Physiol, 1999 Oct. PMID 10516089
    4. Major involvement of Na(+) -dependent multivitamin transporter (SLC5A6/SMVT) in uptake of biotin and pantothenic acid by human brain capillary endothelial cells. Uchida Y, et al. J Neurochem, 2015 Jul. PMID 25809983
    5. Cloning and functional expression of a cDNA encoding a mammalian sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin, and lipoate. Prasad PD, et al. J Biol Chem, 1998 Mar 27. PMID 9516450

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression of SMVT is developmentally regulated in jejunal epithelial brush border membranes
      Title: Comparative analysis of ontogenic changes in renal and intestinal biotin transport in the rat.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables amide transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables biotin transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables biotin transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables iodide transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables iodide transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables monocarboxylate:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pantothenate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pantothenate:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables salt transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sodium-dependent multivitamin transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium-dependent multivitamin transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sodium-dependent multivitamin transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sulfur compound transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables vitamin transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biotin import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biotin import across plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in biotin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biotin transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biotin transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in biotin transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in iodide transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in iodide transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in pantothenate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pantothenate transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in pantothenate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sodium ion import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transport across blood-brain barrier ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in basal plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in brush border membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sodium-dependent multivitamin transporter
    Names
    Na(+)-dependent multivitamin transporter
    solute carrier family 5 (sodium-dependent vitamin transporter), member 6
    solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130746.2 → NP_570102.1  sodium-dependent multivitamin transporter

      See identical proteins and their annotated locations for NP_570102.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      O70247
      UniProtKB/TrEMBL
      A0A8L2R3T7, B4F760
      Related
      ENSRNOP00000075361.1, ENSRNOT00000082623.2
      Conserved Domains (1) summary
      cl00456
      Location:23 → 548
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      31039865..31051671
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039111708.2 → XP_038967636.1  sodium-dependent multivitamin transporter isoform X1

      UniProtKB/Swiss-Prot
      O70247
      UniProtKB/TrEMBL
      A0A8L2R3T7, B4F760
      Conserved Domains (1) summary
      cl00456
      Location:23 → 548
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    2. XM_039111710.2 → XP_038967638.1  sodium-dependent multivitamin transporter isoform X1

      UniProtKB/Swiss-Prot
      O70247
      UniProtKB/TrEMBL
      A0A8L2R3T7, B4F760
      Conserved Domains (1) summary
      cl00456
      Location:23 → 548
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    3. XM_039111709.2 → XP_038967637.1  sodium-dependent multivitamin transporter isoform X1

      UniProtKB/Swiss-Prot
      O70247
      UniProtKB/TrEMBL
      A0A8L2R3T7, B4F760
      Related
      ENSRNOP00000071291.2
      Conserved Domains (1) summary
      cl00456
      Location:23 → 548
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O70247.1 GenPept UniProtKB/Swiss-Prot:O70247

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