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    Sgsm3 small G protein signaling modulator 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362963, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Sgsm3provided by RGD
    Official Full Name
    small G protein signaling modulator 3provided by RGD
    Primary source
    RGD:735113
    See related
    Ensembl:ENSRNOG00000018745 AllianceGenome:RGD:735113
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rutbc3; bdif-1
    Summary
    Predicted to enable GTPase activator activity and small GTPase binding activity. Predicted to be involved in several processes, including Rap protein signal transduction; activation of GTPase activity; and regulation of Rab protein signal transduction. Predicted to be located in cytosol and gap junction. Orthologous to human SGSM3 (small G protein signaling modulator 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 74.2), Muscle (RPKM 54.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    7q34
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (114394724..114424285)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (112514453..112544109)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (122203498..122232993)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene trinucleotide repeat containing adaptor 6B Neighboring gene uncharacterized LOC120093695 Neighboring gene SREK1-interacting protein 1, pseudogene 1 Neighboring gene adenylosuccinate lyase Neighboring gene myocardin related transcription factor A Neighboring gene thymosin, beta 10, pseudogene 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Interaction of small G protein signaling modulator 3 with connexin 43 contributes to myocardial infarction in rat hearts. Lee CY, et al. Biochem Biophys Res Commun, 2017 Sep 16. PMID 28716730
    2. The identification of novel protein, brain-derived integrating factor-1 (BDIF1), which interacts with astrocytic gap junctional protein. Ito T, et al. Neurosci Res, 2011 Jul. PMID 21453730
    3. Novel rab GAP-like protein, CIP85, interacts with connexin43 and induces its degradation. Lan Z, et al. Biochemistry, 2005 Feb 22. PMID 15709751, Free PMC Article
    4. Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway. Yang H, et al. Genomics, 2007 Aug. PMID 17509819
    5. Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways. Fuchs E, et al. J Cell Biol, 2007 Jun 18. PMID 17562788, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. High levels of SGSM3 appeared to induce the turnover of Cx43 through lysosomal degradation in myocardial infarcted rat hearts.
      Title: Interaction of small G protein signaling modulator 3 with connexin 43 contributes to myocardial infarction in rat hearts.
    2. BDIF1 potentially functions in molecular trafficking of astrocytes.
      Title: The identification of novel protein, brain-derived integrating factor-1 (BDIF1), which interacts with astrocytic gap junctional protein.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rap protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Rap protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Rap protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in activation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in plasma membrane to endosome transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in plasma membrane to endosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Rab protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of Rab protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Rab protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT involved_in regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in gap junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in gap junction ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    small G protein signaling modulator 3
    Names
    RUN and TBC1 domain containing 3
    RUN and TBC1 domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198787.2 → NP_942082.2  small G protein signaling modulator 3

      See identical proteins and their annotated locations for NP_942082.2

      Status: VALIDATED

      Source sequence(s)
      BC062060, BM385615, CB581701
      UniProtKB/TrEMBL
      A6HSY2, F1LQU9
      Related
      ENSRNOP00000025381.4, ENSRNOT00000025382.6
      Conserved Domains (3) summary
      cd11813
      Location:497 → 549
      SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
      smart00164
      Location:127 → 338
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam02759
      Location:576 → 727
      RUN; RUN domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      114394724..114424285
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242099.5 → XP_006242161.1  small G protein signaling modulator 3 isoform X2

      UniProtKB/TrEMBL
      A6HSY2
      Conserved Domains (3) summary
      cd11813
      Location:497 → 549
      SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
      smart00164
      Location:127 → 338
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam02759
      Location:576 → 730
      RUN; RUN domain

    2. XM_063263929.1 → XP_063119999.1  small G protein signaling modulator 3 isoform X2

    3. XM_006242096.5 → XP_006242158.1  small G protein signaling modulator 3 isoform X1

      See identical proteins and their annotated locations for XP_006242158.1

      UniProtKB/TrEMBL
      A6HSY2, F1LQU9
      Conserved Domains (3) summary
      cd11813
      Location:497 → 549
      SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
      smart00164
      Location:127 → 338
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam02759
      Location:576 → 727
      RUN; RUN domain

    4. XM_063263928.1 → XP_063119998.1  small G protein signaling modulator 3 isoform X1

      UniProtKB/TrEMBL
      F1LQU9

    5. XM_039079595.2 → XP_038935523.1  small G protein signaling modulator 3 isoform X1

      UniProtKB/TrEMBL
      A6HSY2, F1LQU9
      Conserved Domains (3) summary
      cd11813
      Location:497 → 549
      SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
      smart00164
      Location:127 → 338
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam02759
      Location:576 → 727
      RUN; RUN domain

    6. XM_063263927.1 → XP_063119997.1  small G protein signaling modulator 3 isoform X1

      UniProtKB/TrEMBL
      F1LQU9

    7. XM_017594989.3 → XP_017450478.1  small G protein signaling modulator 3 isoform X1

      UniProtKB/TrEMBL
      A6HSY2, F1LQU9
      Conserved Domains (3) summary
      cd11813
      Location:497 → 549
      SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
      smart00164
      Location:127 → 338
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam02759
      Location:576 → 727
      RUN; RUN domain

    8. XM_063263926.1 → XP_063119996.1  small G protein signaling modulator 3 isoform X1

      UniProtKB/TrEMBL
      F1LQU9
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P6R7.1 GenPept UniProtKB/Swiss-Prot:Q6P6R7

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