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    Acp1 acid phosphatase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24161, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Acp1provided by RGD
    Official Full Name
    acid phosphatase 1provided by RGD
    Primary source
    RGD:2020
    See related
    Ensembl:ENSRNOG00000005260 AllianceGenome:RGD:2020
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables SH3 domain binding activity; acid phosphatase activity; and protein tyrosine phosphatase activity. Involved in chemical synaptic transmission. Located in neuron projection. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; conduct disorder; diabetes mellitus (multiple); diabetic retinopathy; and obesity. Orthologous to human ACP1 (acid phosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 550.1), Spleen (RPKM 393.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    6q16
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (53233937..53249576, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (47506380..47522021, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (49836064..49851714, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120103519 Neighboring gene transmembrane protein 18 Neighboring gene uncharacterized LOC134479359 Neighboring gene ALK and LTK ligand 2 Neighboring gene SH3 and SYLF domain containing 1 Neighboring gene HIRA interacting protein 3, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Reduction of low molecular weight protein-tyrosine phosphatase expression improves hyperglycemia and insulin sensitivity in obese mice. Pandey SK, et al. J Biol Chem, 2007 May 11. PMID 17353188
    2. Smoking and the genetics of signal transduction: an association study on retinopathy in type 1 diabetes. Magrini A, et al. Am J Med Sci, 2002 Dec. PMID 12495297
    3. Low-molecular-weight acid phosphatase (ACP1), obesity, and blood lipid levels in subjects with non-insulin-dependent diabetes mellitus. Lucarini N, et al. Hum Biol, 1997 Aug. PMID 9198310
    4. Phosphotyrosine protein phosphatases and diabetic pregnancy: an association between low molecular weight acid phosphatase and degree of glycemic control. Gloria-Bottini F, et al. Experientia, 1996 Apr 15. PMID 8620937
    5. Enzyme polymorphism and clinical variability of diseases: study of acid phosphatase locus 1 (ACP1) in obese subjects. Bottini E, et al. Hum Biol, 1990 Jun. PMID 2373509

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GRX plays an important role in PDGF-BB-dependent cell proliferation by regulating the redox state of LMW-PTP
      Title: Glutaredoxin modulates platelet-derived growth factor-dependent cell signaling by regulating the redox status of low molecular weight protein-tyrosine phosphatase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SH3 domain binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acid phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acid phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables acid phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables acid phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in chemical synaptic transmission NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sarcolemma ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    low molecular weight phosphotyrosine protein phosphatase
    Names
    LMW-PTP-I low molecular weight phosphotyrosine protein phosphatase isozyme 1
    LMW-PTPase
    acid phosphatase 1, soluble
    low molecular weight cytosolic acid phosphatase
    NP_001129034.1
    NP_001300664.1
    NP_001300669.2
    NP_067085.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135562.1 → NP_001129034.1  low molecular weight phosphotyrosine protein phosphatase isoform B

      See identical proteins and their annotated locations for NP_001129034.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the coding region compared to variant 1. The resulting protein (isoform B) is the same length as isoform A and has the same N- and C-termini but differs at an internal region.
      Source sequence(s)
      BC158763
      UniProtKB/TrEMBL
      A0A0G2K394, A0A9K3Y7U9, B0BNC1
      Related
      ENSRNOP00000072548.2, ENSRNOT00000077442.2
      Conserved Domains (1) summary
      cd16343
      Location:7 → 155
      LMWPTP; Low molecular weight protein tyrosine phosphatase

    2. NM_001313735.1 → NP_001300664.1  low molecular weight phosphotyrosine protein phosphatase isoform C

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting protein (isoform C) is shorter than isoform A.
      Source sequence(s)
      FM059981, JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AMP6
      Related
      ENSRNOP00000095909.1, ENSRNOT00000109768.1
      Conserved Domains (1) summary
      cd00115
      Location:7 → 117
      LMWPc; Low molecular weight phosphatase family;

    3. NM_001313740.2 → NP_001300669.2  low molecular weight phosphotyrosine protein phosphatase isoform D

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (D) has a distinct N-terminus and is shorter than isoform A.
      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AKL4
      Related
      ENSRNOP00000093729.1, ENSRNOT00000108337.1
      Conserved Domains (1) summary
      cd16343
      Location:9 → 149
      LMWPTP; Low molecular weight protein tyrosine phosphatase

    4. NM_021262.3 → NP_067085.1  low molecular weight phosphotyrosine protein phosphatase isoform A

      See identical proteins and their annotated locations for NP_067085.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript.
      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      P41498, Q9R138
      UniProtKB/TrEMBL
      A6HB36, Z4YNF4
      Related
      ENSRNOP00000007287.8, ENSRNOT00000007287.8
      Conserved Domains (1) summary
      cd16343
      Location:7 → 155
      LMWPTP; Low molecular weight protein tyrosine phosphatase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      53233937..53249576 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P41498.3 GenPept UniProtKB/Swiss-Prot:P41498

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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