Trim72 tripartite motif-containing 72 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trim72provided by MGI
Official Full Name: tripartite motif-containing 72provided by MGI
Primary source: MGI:MGI:3612190
See related: Ensembl:ENSMUSG00000042828 AllianceGenome:MGI:3612190
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MG53
Summary: Enables phosphatidylserine binding activity; ubiquitin conjugating enzyme binding activity; and ubiquitin protein ligase activity. Involved in several processes, including muscle organ development; plasma membrane repair; and protein homooligomerization. Acts upstream of or within negative regulation of myotube differentiation; negative regulation of signal transduction; and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cytoplasmic vesicle membrane and sarcolemma. Is expressed in heart; heart left ventricle; heart right ventricle; left atrium; and right atrium. Orthologous to human TRIM72 (tripartite motif containing 72). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in heart adult (RPKM 65.8), colon adult (RPKM 6.5) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F3; 7 69.89 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (127602684..127610565)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (128003462..128011393)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MG53 protects against Coxsackievirus B3-induced acute viral myocarditis in mice by inhibiting NLRP3 inflammasome-mediated pyroptosis via the NF-kappaB signaling pathway.
Title: MG53 protects against Coxsackievirus B3-induced acute viral myocarditis in mice by inhibiting NLRP3 inflammasome-mediated pyroptosis via the NF-κB signaling pathway.
Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane.
Title: Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane.
Mitsugumin 53 mitigation of ischemia-reperfusion injury in a mouse model.
Title: Mitsugumin 53 mitigation of ischemia-reperfusion injury in a mouse model.
Alkylation Repair Homolog 5 Regulates N(6)-methyladenosine (m6A) Methylation of Mitsugumin 53 to Attenuate Myocardial Infarction by Inhibiting Apoptosis and Oxidative Stress.
Title: Alkylation Repair Homolog 5 Regulates N(6)-methyladenosine (m6A) Methylation of Mitsugumin 53 to Attenuate Myocardial Infarction by Inhibiting Apoptosis and Oxidative Stress.
TRIM72 Alleviates Muscle Inflammation in mdx Mice via Promoting Mitophagy-Mediated NLRP3 Inflammasome Inactivation.
Title: TRIM72 Alleviates Muscle Inflammation in mdx Mice via Promoting Mitophagy-Mediated NLRP3 Inflammasome Inactivation.
MG53 protein rejuvenates hUC-MSCs and facilitates their therapeutic effects in AD mice by activating Nrf2 signaling pathway.
Title: MG53 protein rejuvenates hUC-MSCs and facilitates their therapeutic effects in AD mice by activating Nrf2 signaling pathway.
MG53 suppresses NF-kappaB activation to mitigate age-related heart failure.
Title: MG53 suppresses NF-κB activation to mitigate age-related heart failure.
The cell membrane repair protein MG53 modulates transcription factor NF-kappaB signaling to control kidney fibrosis.
Title: The cell membrane repair protein MG53 modulates transcription factor NF-κB signaling to control kidney fibrosis.
MG53 E3 Ligase-Dead Mutant Protects Diabetic Hearts From Acute Ischemic/Reperfusion Injury and Ameliorates Diet-Induced Cardiometabolic Damage.
Title: MG53 E3 Ligase-Dead Mutant Protects Diabetic Hearts From Acute Ischemic/Reperfusion Injury and Ameliorates Diet-Induced Cardiometabolic Damage.
Cardiac Ischemic Preconditioning Promotes MG53 Secretion Through H2O2-Activated Protein Kinase C-delta Signaling.
Title: Cardiac Ischemic Preconditioning Promotes MG53 Secretion Through H(2)O(2)-Activated Protein Kinase C-δ Signaling.

Submit: New GeneRIF Correction See all GeneRIFs (50)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (7) 1 citation
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:238080

AI450003 (e-PCR)
- UniSTS:160901

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables mitogen-activated protein kinase kinase kinase binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylserine binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin conjugating enzyme binding	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in exocytosis	TAS Traceable Author Statement more info	PubMed
involved_in muscle organ development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle system process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of insulin-like growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of myotube differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within plasma membrane repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plasma membrane repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein homooligomerization	IPI Inferred from Physical Interaction more info	PubMed
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle budding from membrane	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle membrane	TAS Traceable Author Statement more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in sarcolemma	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: tripartite motif-containing protein 72

Names: mitsugumin 53

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001079932.3 → NP_001073401.1 tripartite motif-containing protein 72

See identical proteins and their annotated locations for NP_001073401.1

Status: VALIDATED

Source sequence(s)

AB231474, AC124461

Consensus CDS

CCDS40148.1

UniProtKB/Swiss-Prot

B2RWH7, Q1XH17, Q6NX76

Related

ENSMUSP00000079832.5, ENSMUST00000081042.6

Conserved Domains (4) summary

pfam03528
Location:139 → 253

Rabaptin

cd19797
Location:84 → 125

Bbox2_TRIM72_C-IV; B-box-type 2 zinc finger found in tripartite motif-containing protein 72 (TRIM72) and similar proteins

cl02614
Location:278 → 470

SPRY; SPRY domain

cl17238
Location:11 → 57

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

127602684..127610565

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006508002.5 → XP_006508065.1 tripartite motif-containing protein 72 isoform X1

See identical proteins and their annotated locations for XP_006508065.1

UniProtKB/Swiss-Prot

B2RWH7, Q1XH17, Q6NX76

Related

ENSMUSP00000101855.2, ENSMUST00000106248.8

Conserved Domains (4) summary

pfam03528
Location:139 → 253

Rabaptin

cd19797
Location:84 → 125

Bbox2_TRIM72_C-IV; B-box-type 2 zinc finger found in tripartite motif-containing protein 72 (TRIM72) and similar proteins

cl02614
Location:278 → 470

SPRY; SPRY domain

cl17238
Location:11 → 57

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
XM_006508003.5 → XP_006508066.1 tripartite motif-containing protein 72 isoform X2

Conserved Domains (4) summary

cd00162
Location:14 → 56

RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]

pfam03528
Location:139 → 238

Rabaptin

cl00034
Location:84 → 125

Bbox_SF; B-box-type zinc finger superfamily

cl17238
Location:11 → 57

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain