Cstdc2 cystatin domain containing 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cstdc2provided by MGI
Official Full Name: cystatin domain containing 2provided by MGI
Primary source: MGI:MGI:1924955
See related: Ensembl:ENSMUSG00000027446 AllianceGenome:MGI:1924955
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mCST E2; 9230104L09Rik
Summary: Predicted to be involved in antimicrobial humoral response. Predicted to be active in extracellular space. Is expressed in epididymis and testis. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward genital fat pad adult (RPKM 263.3) See more
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Genomic context

Location:: 2 G3; 2 73.58 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (148686540..148692882, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (148844620..148850962, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

identification and characterization; investigated the tissue distribution and localization of the corresponding mRNA and examined its regulation in the epididymis by testosterone and/or 17ss-estradiol
Title: Cystatin E1 and E2, new members of male reproductive tract subgroup within cystatin type 2 family.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

General gene information

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Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in antimicrobial humoral response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cystatin E2

Names: Cystatin 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029960.3 → NP_084236.1 cystatin E2 precursor

See identical proteins and their annotated locations for NP_084236.1

Status: VALIDATED

Source sequence(s)

AK020314, BB073321

Consensus CDS

CCDS16851.1

UniProtKB/TrEMBL

Q3SXH5, Q9D264

Related

ENSMUSP00000028937.3, ENSMUST00000028937.3

Conserved Domains (1) summary

cl09238
Location:39 → 113

CY; Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

148686540..148692882 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011239843.3 → XP_011238145.1 cystatin E2 isoform X1

UniProtKB/TrEMBL

Q3SXH5

Conserved Domains (1) summary

cl09238
Location:39 → 100

CY; Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.