pik3c2a phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pik3c2aprovided by ZNC
Official Full Name: phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alphaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030328-39
See related: Ensembl:ENSDARG00000060841 AllianceGenome:ZFIN:ZDB-GENE-030328-39
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sb:cb156; wu:fc02a04; si:dkey-24l11.7
Summary: Predicted to enable 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Acts upstream of or within angiogenesis. Predicted to be part of phosphatidylinositol 3-kinase complex. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including axis; heart tube; nervous system; notochord; and pectoral fin musculature. Orthologous to human PIK3C2A (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 18

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (27001065..27073137)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (27018705..27090752)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation.
Title: PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

fc02a04.x1 (e-PCR)
- UniSTS:192048

fc02a04.x1 (e-PCR)
- UniSTS:192049

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphatidylinositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol-3-phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphatidylinositol 3-kinase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

Names: phosphoinositide-3-kinase, class 2, alpha polypeptide

XP_005159362.2

EC 2.7.1.154

XP_005159363.2

EC 2.7.1.154

XP_021323495.1

EC 2.7.1.154

XP_021323496.1

EC 2.7.1.154

XP_021323497.1

EC 2.7.1.154

XP_021330104.1

EC 2.7.1.154

XP_021330105.1

EC 2.7.1.154

XP_021330106.1

EC 2.7.1.154

XP_700029.5

EC 2.7.1.154

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007129.7 Reference GRCz11 Primary Assembly

Range

27001065..27073137

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021467820.1 → XP_021323495.1 phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1

UniProtKB/TrEMBL

A0A8M9PQU0

Related

ENSDARP00000120821.1, ENSDART00000133547.2

Conserved Domains (7) summary

cd07289
Location:1428 → 1536

PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases

cd04012
Location:681 → 852

C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

cd08381
Location:1565 → 1686

C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

pfam00794
Location:420 → 507

PI3K_rbd; PI3-kinase family, ras-binding domain

cl00271
Location:872 → 1038

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...

cl21453
Location:1045 → 1397

PKc_like; Protein Kinases, catalytic domain

cl25716
Location:137 → 207

Amelogenin; Amelogenin
XM_021467822.1 → XP_021323497.1 phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X2

UniProtKB/TrEMBL

A0A8M9P1D7, F6NMW9

Related

ENSDARP00000080566.5, ENSDART00000086131.6

Conserved Domains (7) summary

cd07289
Location:1422 → 1530

PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases

cd04012
Location:675 → 846

C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

cd08381
Location:1559 → 1680

C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

pfam00794
Location:420 → 507

PI3K_rbd; PI3-kinase family, ras-binding domain

cl00271
Location:866 → 1032

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...

cl21453
Location:1039 → 1391

PKc_like; Protein Kinases, catalytic domain

cl25716
Location:137 → 207

Amelogenin; Amelogenin
XM_021467821.1 → XP_021323496.1 phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1

UniProtKB/TrEMBL

A0A8M9PQU0

Conserved Domains (7) summary

cd07289
Location:1428 → 1536

PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases

cd04012
Location:681 → 852

C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

cd08381
Location:1565 → 1686

C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

pfam00794
Location:420 → 507

PI3K_rbd; PI3-kinase family, ras-binding domain

cl00271
Location:872 → 1038

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...

cl21453
Location:1045 → 1397

PKc_like; Protein Kinases, catalytic domain

cl25716
Location:137 → 207

Amelogenin; Amelogenin

Reference GRCz11 ALT_DRER_TU_1

Genomic

NW_018395030.1 Reference GRCz11 ALT_DRER_TU_1

Range

181391..256038

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005159305.4 → XP_005159362.2 phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1

UniProtKB/TrEMBL

A0A8M2B5U1

Conserved Domains (7) summary

cd07289
Location:1428 → 1536

PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases

cd04012
Location:681 → 852

C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

cd08381
Location:1565 → 1686

C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

pfam00794
Location:420 → 507

PI3K_rbd; PI3-kinase family, ras-binding domain

cl00271
Location:872 → 1038

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...

cl21453
Location:1045 → 1397

PKc_like; Protein Kinases, catalytic domain

cl25716
Location:137 → 207

Amelogenin
XM_694937.8 → XP_700029.5 phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X2

UniProtKB/TrEMBL

A0A2R8QSP1, A0A8N7T897

Conserved Domains (7) summary

cd07289
Location:1422 → 1530

PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases

cd04012
Location:675 → 846

C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

cd08381
Location:1559 → 1680

C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

pfam00794
Location:420 → 507

PI3K_rbd; PI3-kinase family, ras-binding domain

cl00271
Location:866 → 1032

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...

cl21453
Location:1039 → 1391

PKc_like; Protein Kinases, catalytic domain

cl25716
Location:137 → 207

Amelogenin
XM_005159306.3 → XP_005159363.2 phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1

UniProtKB/TrEMBL

A0A8M2B5U1

Conserved Domains (7) summary

cd07289
Location:1428 → 1536

PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases

cd04012
Location:681 → 852

C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

cd08381
Location:1565 → 1686

C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

pfam00794
Location:420 → 507

PI3K_rbd; PI3-kinase family, ras-binding domain

cl00271
Location:872 → 1038

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...

cl21453
Location:1045 → 1397

PKc_like; Protein Kinases, catalytic domain

cl25716
Location:137 → 207

Amelogenin

Reference GRCz11 ALT_DRER_TU_2

Genomic

NW_018395342.1 Reference GRCz11 ALT_DRER_TU_2

Range

525199..584853

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021474429.1 → XP_021330104.1 phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X3

UniProtKB/TrEMBL

A0A8M9PYW4

Conserved Domains (5) summary

cd04012
Location:681 → 852

C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

pfam00794
Location:420 → 507

PI3K_rbd; PI3-kinase family, ras-binding domain

cl00271
Location:872 → 1038

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...

cl21453
Location:1045 → 1185

PKc_like; Protein Kinases, catalytic domain

cl25716
Location:137 → 207

Amelogenin
XM_021474431.1 → XP_021330106.1 phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X4

UniProtKB/TrEMBL

A0A8M9Q547

Conserved Domains (5) summary

cd04012
Location:675 → 846

C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

pfam00794
Location:420 → 507

PI3K_rbd; PI3-kinase family, ras-binding domain

cl00271
Location:866 → 1032

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...

cl21453
Location:1039 → 1179

PKc_like; Protein Kinases, catalytic domain

cl25716
Location:137 → 207

Amelogenin
XM_021474430.1 → XP_021330105.1 phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X3

UniProtKB/TrEMBL

A0A8M9PYW4

Conserved Domains (5) summary

cd04012
Location:681 → 852

C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

pfam00794
Location:420 → 507

PI3K_rbd; PI3-kinase family, ras-binding domain

cl00271
Location:872 → 1038

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...

cl21453
Location:1045 → 1185

PKc_like; Protein Kinases, catalytic domain

cl25716
Location:137 → 207

Amelogenin