U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    aco1 aconitase 1, soluble [ Danio rerio (zebrafish) ]

    Gene ID: 568448, updated on 27-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    aco1provided by ZNC
    Official Full Name
    aconitase 1, solubleprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-031118-76
    See related
    Ensembl:ENSDARG00000026376 AllianceGenome:ZFIN:ZDB-GENE-031118-76
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    irp1; wu:fo75b03
    Summary
    Predicted to enable aconitate hydratase activity; iron-responsive element binding activity; and iron-sulfur cluster binding activity. Predicted to be involved in citrate metabolic process and tricarboxylic acid cycle. Predicted to act upstream of or within cellular iron ion homeostasis and response to iron(II) ion. Predicted to be located in cytoplasm. Predicted to be active in cytosol and mitochondrion. Is expressed in blood and presumptive blood. Orthologous to human ACO1 (aconitase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    chromosome: 7
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (71458645..71489889, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (71221831..71248624, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene leucine-rich repeat LGI family, member 2a Neighboring gene Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase Neighboring gene leucine-rich repeat-containing protein 72-like Neighboring gene protein phosphatase 1, regulatory subunit 15A

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesis. Wingert RA, et al. Nature, 2005 Aug 18. PMID 16110529
    2. Gender-specific proteomic responses in zebrafish liver following exposure to a selected mixture of brominated flame retardants. Kling P, et al. Ecotoxicol Environ Saf, 2008 Oct. PMID 18258299
    3. Malate enhances survival of zebrafish against Vibrio alginolyticus infection in the same manner as taurine. Yang MJ, et al. Virulence, 2020 Dec. PMID 32316833, Free PMC Article
    4. Thifluzamide induces the toxic effects on zebrafish (Danio rerio) via inhibition of succinate dehydrogenase (SDH). Yang Y, et al. Environ Pollut, 2020 Oct. PMID 32806454
    5. Temporal pattern of loss/persistence of duplicate genes involved in signal transduction and metabolic pathways after teleost-specific genome duplication. Sato Y, et al. BMC Evol Biol, 2009 Jun 5. PMID 19500364, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 3 iron, 4 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 4 iron, 4 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aconitate hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aconitate hydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron-responsive element binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in citrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    cytoplasmic aconitate hydratase
    Names
    iron regulatory protein 1
    NP_001030155.1
    XP_005172430.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034983.1 → NP_001030155.1  cytoplasmic aconitate hydratase

      See identical proteins and their annotated locations for NP_001030155.1

      Status: PROVISIONAL

      Source sequence(s)
      DQ083332
      UniProtKB/TrEMBL
      Q3YMK9
      Related
      ENSDARP00000045252.6, ENSDART00000045253.8
      Conserved Domains (3) summary
      cd01586
      Location:82 → 566
      AcnA_IRP; Aconitase A catalytic domain
      cd01580
      Location:670 → 837
      AcnA_IRP_Swivel; Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group ...
      PTZ00092
      Location:3 → 886
      PTZ00092; aconitate hydratase-like protein; Provisional

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      71458645..71489889 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005172373.4 → XP_005172430.1  cytoplasmic aconitate hydratase isoform X1

      UniProtKB/TrEMBL
      A0A8M2BJL9, F1QM42
      Conserved Domains (3) summary
      cd01586
      Location:82 → 566
      AcnA_IRP; Aconitase A catalytic domain
      cd01580
      Location:670 → 837
      AcnA_IRP_Swivel; Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group ...
      PTZ00092
      Location:3 → 886
      PTZ00092; aconitate hydratase-like protein; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.