Dhrs4 dehydrogenase/reductase 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dhrs4provided by RGD
Official Full Name: dehydrogenase/reductase 4provided by RGD
Primary source: RGD:708482
See related: Ensembl:ENSRNOG00000018239 AllianceGenome:RGD:708482
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PSCD
Summary: Predicted to enable several functions, including identical protein binding activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; and retinal dehydrogenase activity. Predicted to be involved in several processes, including positive regulation of reactive oxygen species metabolic process; retinal metabolic process; and steroid metabolic process. Located in peroxisome. Orthologous to several human genes including DHRS4 (dehydrogenase/reductase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 361.9), Liver (RPKM 304.4) and 9 other tissues See more
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Genomic context

Location:: 15p13

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (32924482..32948103)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (28966544..28978135)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (34155043..34167073)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

R. norvegicus DHRS2 and DHRS4 genes are syntenic outparalogs that originated from a duplication of the DHRS4 gene that took place before the formation of the mammalian clade. R. norvegicus genes are orthologs of human DHRS2 and DHRS4 genes respectively.
Title: Molecular and functional evolution of human DHRS2 and DHRS4 duplicated genes.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE114851 (e-PCR)
- UniSTS:261655

BE113024 (e-PCR)
- UniSTS:246617

RH130081 (e-PCR)
- UniSTS:213369

BE120291 (e-PCR)
- UniSTS:247289

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-keto sterol reductase activity	ISO Inferred from Sequence Orthology more info
enables alcohol dehydrogenase [NAD(P)+] activity	ISO Inferred from Sequence Orthology more info
enables all-trans-retinol dehydrogenase (NADP+) activity	ISO Inferred from Sequence Orthology more info
enables all-trans-retinol dehydrogenase (NADP+) activity	ISS Inferred from Sequence or Structural Similarity more info
enables carbonyl reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables carbonyl reductase (NADPH) activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	ISO Inferred from Sequence Orthology more info
enables retinal dehydrogenase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in alcohol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cellular ketone metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cellular ketone metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinal metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within retinal metabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinoid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinoid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in retinol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in steroid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in steroid metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in peroxisomal membrane	ISO Inferred from Sequence Orthology more info
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dehydrogenase/reductase SDR family member 4

Names: CR; DCR-AKL; NADP-retinol dehydrogenase; NADPH-dependent carbonyl reductase; NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase; NADPH-dependent retinol dehydrogenase/reductase; NDRD; PHCR; carbonyl reductase; dehydrogenase/reductase (SDR family) member 4; peroxisomal short-chain alcohol dehydrogenase; short chain dehydrogenase/reductase family 25C member 2

NP_695227.2

EC 1.1.1.184

EC 1.1.1.300

XP_038948968.1

EC 1.1.1.184

EC 1.1.1.300

XP_063130103.1

EC 1.1.1.184

EC 1.1.1.300

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153315.2 → NP_695227.2 dehydrogenase/reductase SDR family member 4

See identical proteins and their annotated locations for NP_695227.2

Status: VALIDATED

Source sequence(s)

BC070961

UniProtKB/Swiss-Prot

Q6IRD4, Q8VID1

UniProtKB/TrEMBL

A0A8I5ZUW8

Related

ENSRNOP00000024782.3, ENSRNOT00000024782.5

Conserved Domains (1) summary

cd08936
Location:24 → 279

CR_SDR_c; Porcine peroxisomal carbonyl reductase like, classical (c) SDR

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

32924482..32948103

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063274033.1 → XP_063130103.1 dehydrogenase/reductase SDR family member 4 isoform X1

UniProtKB/Swiss-Prot

Q6IRD4, Q8VID1
XM_039093040.2 → XP_038948968.1 dehydrogenase/reductase SDR family member 4 isoform X2

UniProtKB/TrEMBL

A0A8I5ZUW8

Conserved Domains (1) summary

cl21454
Location:24 → 225

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins