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    Stag2 STAG2 cohesin complex component [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313304, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Stag2provided by RGD
    Official Full Name
    STAG2 cohesin complex componentprovided by RGD
    Primary source
    RGD:1562042
    See related
    Ensembl:ENSRNOG00000029885 AllianceGenome:RGD:1562042
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562042
    Summary
    Predicted to enable chromatin binding activity. Predicted to be involved in mitotic spindle assembly and sister chromatid cohesion. Predicted to act upstream of or within stem cell population maintenance. Predicted to be located in mitotic spindle pole and nuclear matrix. Predicted to be part of cohesin complex. Predicted to be active in chromatin and nucleus. Human ortholog(s) of this gene implicated in Mullegama-Klein-Martinez syndrome and holoprosencephaly. Orthologous to human STAG2 (stromal antigen 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 365.0), Spleen (RPKM 294.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    Xq35
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (125839660..125971209)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (120974687..121105677)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (128493603..128624418)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene THO complex subunit 2 Neighboring gene similar to 40S ribosomal protein S2 Neighboring gene X-linked inhibitor of apoptosis Neighboring gene U2 spliceosomal RNA Neighboring gene actin, beta, pseudogene 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. De novo loss-of-function variants in STAG2 are associated with developmental delay, microcephaly, and congenital anomalies. Mullegama SV, et al. Am J Med Genet A, 2017 May. PMID 28296084, Free PMC Article
    2. Familial STAG2 germline mutation defines a new human cohesinopathy. Soardi FC, et al. NPJ Genom Med, 2017. PMID 29263825, Free PMC Article
    3. Phosphorylation-enabled binding of SGO1-PP2A to cohesin protects sororin and centromeric cohesion during mitosis. Liu H, et al. Nat Cell Biol, 2013 Jan. PMID 23242214, Free PMC Article
    4. A potential role for human cohesin in mitotic spindle aster assembly. Gregson HC, et al. J Biol Chem, 2001 Dec 14. PMID 11590136
    5. Cornelia de Lange Syndrome and the link between chromosomal function, DNA repair and developmental gene regulation. Strachan T. Curr Opin Genet Dev, 2005 Jun. PMID 15917200

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic spindle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sister chromatid cohesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cohesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cohesin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitotic cohesin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cohesin subunit SA-2
    Names
    stromal antigen 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001173507.1 → NP_001166978.1  cohesin subunit SA-2

      See identical proteins and their annotated locations for NP_001166978.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      D3ZXT2
      Related
      ENSRNOP00000044231.3, ENSRNOT00000044240.6
      Conserved Domains (2) summary
      pfam08514
      Location:157 → 265
      STAG; STAG domain
      cl21454
      Location:116 → 145
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      125839660..125971209
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008773521.4 → XP_008771743.1  cohesin subunit SA-2 isoform X1

      See identical proteins and their annotated locations for XP_008771743.1

      UniProtKB/TrEMBL
      A0A0G2K4D9
      Related
      ENSRNOP00000073004.1
      Conserved Domains (1) summary
      pfam08514
      Location:157 → 265
      STAG; STAG domain

    2. XM_039099694.2 → XP_038955622.1  cohesin subunit SA-2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4D9
      Conserved Domains (1) summary
      pfam08514
      Location:157 → 265
      STAG; STAG domain

    3. XM_063279980.1 → XP_063136050.1  cohesin subunit SA-2 isoform X2

      UniProtKB/TrEMBL
      D3ZXT2

    4. XM_017602032.3 → XP_017457521.1  cohesin subunit SA-2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4D9
      Conserved Domains (1) summary
      pfam08514
      Location:157 → 265
      STAG; STAG domain

    5. XM_063279976.1 → XP_063136046.1  cohesin subunit SA-2 isoform X2

      UniProtKB/TrEMBL
      D3ZXT2

    6. XM_039099693.2 → XP_038955621.1  cohesin subunit SA-2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4D9
      Conserved Domains (1) summary
      pfam08514
      Location:157 → 265
      STAG; STAG domain

    7. XM_063279977.1 → XP_063136047.1  cohesin subunit SA-2 isoform X2

      UniProtKB/TrEMBL
      D3ZXT2

    8. XM_063279975.1 → XP_063136045.1  cohesin subunit SA-2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4D9

    9. XM_063279978.1 → XP_063136048.1  cohesin subunit SA-2 isoform X2

      UniProtKB/TrEMBL
      D3ZXT2

    10. XM_006257503.5 → XP_006257565.1  cohesin subunit SA-2 isoform X1

      See identical proteins and their annotated locations for XP_006257565.1

      UniProtKB/TrEMBL
      A0A0G2K4D9
      Conserved Domains (1) summary
      pfam08514
      Location:157 → 265
      STAG; STAG domain

    11. XM_063279979.1 → XP_063136049.1  cohesin subunit SA-2 isoform X2

      UniProtKB/TrEMBL
      D3ZXT2
    Nucleotide Protein Strain
    Heading Accession and Version

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