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    Adamtsl4 ADAMTS-like 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310670, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Adamtsl4provided by RGD
    Official Full Name
    ADAMTS-like 4provided by RGD
    Primary source
    RGD:1561012
    See related
    Ensembl:ENSRNOG00000049385 AllianceGenome:RGD:1561012
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tsrc1
    Summary
    Predicted to enable identical protein binding activity and protease binding activity. Predicted to be involved in positive regulation of apoptotic process. Predicted to act upstream of or within epithelial cell development and extracellular matrix organization. Predicted to be located in interstitial matrix. Human ortholog(s) of this gene implicated in autosomal recessive isolated ectopia lentis 2 and ectopia lentis with ectopia of pupil. Orthologous to human ADAMTSL4 (ADAMTS like 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 111.6), Muscle (RPKM 100.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    2q34
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (185924582..185936039, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (183235634..183247091, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (197803572..197815058, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene endosulfine alpha Neighboring gene MCL1 apoptosis regulator, BCL2 family member Neighboring gene uncharacterized LOC120100878 Neighboring gene uncharacterized LOC120100879 Neighboring gene extracellular matrix protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cathepsin B and its interacting proteins, bikunin and TSRC1, correlate with TNF-induced apoptosis of ovarian cancer cells OV-90. Liu J, et al. FEBS Lett, 2006 Jan 9. PMID 16364318
    2. Disruption of murine Adamtsl4 results in zonular fiber detachment from the lens and in retinal pigment epithelium dedifferentiation. Collin GB, et al. Hum Mol Genet, 2015 Dec 15. PMID 26405179, Free PMC Article
    3. Transcriptome-based systematic identification of extracellular matrix proteins. Manabe R, et al. Proc Natl Acad Sci U S A, 2008 Sep 2. PMID 18757743, Free PMC Article
    4. Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Abonnenc M, et al. Circ Res, 2013 Oct 25. PMID 24006456
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC116260

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protease binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within epithelial cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within extracellular matrix organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within pigment cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in interstitial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ADAMTS-like protein 4
    Names
    ADAMTSL-4
    thrombospondin repeat protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034012.1 → NP_001029184.1  ADAMTS-like protein 4 precursor

      See identical proteins and their annotated locations for NP_001029184.1

      Status: PROVISIONAL

      Source sequence(s)
      BC099119
      UniProtKB/Swiss-Prot
      Q4FZU4
      Related
      ENSRNOP00000063998.1, ENSRNOT00000074156.2
      Conserved Domains (3) summary
      smart00209
      Location:46 → 75
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:446 → 559
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:989 → 1018
      PLAC; PLAC (protease and lacunin) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      185924582..185936039 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017590903.2 → XP_017446392.1  ADAMTS-like protein 4 isoform X2

      UniProtKB/Swiss-Prot
      Q4FZU4
      Conserved Domains (3) summary
      smart00209
      Location:46 → 75
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:446 → 559
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:989 → 1018
      PLAC; PLAC (protease and lacunin) domain

    2. XM_039102360.1 → XP_038958288.1  ADAMTS-like protein 4 isoform X1

      Conserved Domains (4) summary
      PHA03247
      Location:24 → 358
      PHA03247; large tegument protein UL36; Provisional
      pfam05986
      Location:451 → 564
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:994 → 1023
      PLAC; PLAC (protease and lacunin) domain
      pfam19030
      Location:690 → 746
      TSP1_ADAMTS; Thrombospondin type 1 domain

    3. XM_039102358.1 → XP_038958286.1  ADAMTS-like protein 4 isoform X1

      Conserved Domains (4) summary
      PHA03247
      Location:24 → 358
      PHA03247; large tegument protein UL36; Provisional
      pfam05986
      Location:451 → 564
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:994 → 1023
      PLAC; PLAC (protease and lacunin) domain
      pfam19030
      Location:690 → 746
      TSP1_ADAMTS; Thrombospondin type 1 domain

    4. XM_063281876.1 → XP_063137946.1  ADAMTS-like protein 4 isoform X2

      UniProtKB/Swiss-Prot
      Q4FZU4

    5. XM_039102363.1 → XP_038958291.1  ADAMTS-like protein 4 isoform X1

      Conserved Domains (4) summary
      PHA03247
      Location:24 → 358
      PHA03247; large tegument protein UL36; Provisional
      pfam05986
      Location:451 → 564
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:994 → 1023
      PLAC; PLAC (protease and lacunin) domain
      pfam19030
      Location:690 → 746
      TSP1_ADAMTS; Thrombospondin type 1 domain

    6. XM_017590906.3 → XP_017446395.1  ADAMTS-like protein 4 isoform X2

      UniProtKB/Swiss-Prot
      Q4FZU4
      Conserved Domains (3) summary
      smart00209
      Location:46 → 75
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:446 → 559
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:989 → 1018
      PLAC; PLAC (protease and lacunin) domain

    7. XM_039102362.2 → XP_038958290.1  ADAMTS-like protein 4 isoform X1

      Conserved Domains (4) summary
      PHA03247
      Location:24 → 358
      PHA03247; large tegument protein UL36; Provisional
      pfam05986
      Location:451 → 564
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:994 → 1023
      PLAC; PLAC (protease and lacunin) domain
      pfam19030
      Location:690 → 746
      TSP1_ADAMTS; Thrombospondin type 1 domain

    8. XM_063281874.1 → XP_063137944.1  ADAMTS-like protein 4 isoform X2

      UniProtKB/Swiss-Prot
      Q4FZU4

    9. XM_039102361.1 → XP_038958289.1  ADAMTS-like protein 4 isoform X1

      Conserved Domains (4) summary
      PHA03247
      Location:24 → 358
      PHA03247; large tegument protein UL36; Provisional
      pfam05986
      Location:451 → 564
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:994 → 1023
      PLAC; PLAC (protease and lacunin) domain
      pfam19030
      Location:690 → 746
      TSP1_ADAMTS; Thrombospondin type 1 domain

    10. XM_063281878.1 → XP_063137948.1  ADAMTS-like protein 4 isoform X2

      UniProtKB/Swiss-Prot
      Q4FZU4

    11. XM_039102359.2 → XP_038958287.1  ADAMTS-like protein 4 isoform X1

      Conserved Domains (4) summary
      PHA03247
      Location:24 → 358
      PHA03247; large tegument protein UL36; Provisional
      pfam05986
      Location:451 → 564
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:994 → 1023
      PLAC; PLAC (protease and lacunin) domain
      pfam19030
      Location:690 → 746
      TSP1_ADAMTS; Thrombospondin type 1 domain

    12. XM_063281875.1 → XP_063137945.1  ADAMTS-like protein 4 isoform X2

      UniProtKB/Swiss-Prot
      Q4FZU4

    13. XM_039102364.2 → XP_038958292.1  ADAMTS-like protein 4 isoform X1

      Conserved Domains (4) summary
      PHA03247
      Location:24 → 358
      PHA03247; large tegument protein UL36; Provisional
      pfam05986
      Location:451 → 564
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:994 → 1023
      PLAC; PLAC (protease and lacunin) domain
      pfam19030
      Location:690 → 746
      TSP1_ADAMTS; Thrombospondin type 1 domain

    14. XM_017590907.3 → XP_017446396.1  ADAMTS-like protein 4 isoform X2

      UniProtKB/Swiss-Prot
      Q4FZU4
      Conserved Domains (3) summary
      smart00209
      Location:46 → 75
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:446 → 559
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:989 → 1018
      PLAC; PLAC (protease and lacunin) domain

    15. XM_063281877.1 → XP_063137947.1  ADAMTS-like protein 4 isoform X2

      UniProtKB/Swiss-Prot
      Q4FZU4

    16. XM_039102367.2 → XP_038958295.1  ADAMTS-like protein 4 isoform X4

      Conserved Domains (3) summary
      PHA03247
      Location:24 → 358
      PHA03247; large tegument protein UL36; Provisional
      pfam05986
      Location:451 → 564
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam19030
      Location:690 → 746
      TSP1_ADAMTS; Thrombospondin type 1 domain

    17. XM_039102366.2 → XP_038958294.1  ADAMTS-like protein 4 isoform X3

      Conserved Domains (2) summary
      PHA03247
      Location:24 → 358
      PHA03247; large tegument protein UL36; Provisional
      pfam05986
      Location:451 → 564
      ADAM_spacer1; ADAM-TS Spacer 1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4FZU4.1 GenPept UniProtKB/Swiss-Prot:Q4FZU4

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