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    Cnr2 cannabinoid receptor 2 [ Mus musculus (house mouse) ]

    Gene ID: 12802, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Cnr2provided by MGI
    Official Full Name
    cannabinoid receptor 2provided by MGI
    Primary source
    MGI:MGI:104650
    See related
    Ensembl:ENSMUSG00000062585 AllianceGenome:MGI:104650
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CB2; CB-2; CB2-R
    Summary
    Predicted to enable cannabinoid receptor activity. Acts upstream of or within leukocyte chemotaxis. Predicted to be located in dendrite; endoplasmic reticulum; and neuronal cell body. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and liver and biliary system. Orthologous to human CNR2 (cannabinoid receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in spleen adult (RPKM 19.7), mammary gland adult (RPKM 6.0) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cnr2 in Genome Data Viewer
    Location:
    4 D3; 4 68.01 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (135622500..135647530)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (135895189..135920219)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:135411492-135411675 Neighboring gene STARR-positive B cell enhancer ABC_E7999 Neighboring gene serine and arginine-rich splicing factor 10 Neighboring gene STARR-positive B cell enhancer ABC_E4683 Neighboring gene STARR-positive B cell enhancer ABC_E1660 Neighboring gene proline-rich nuclear receptor coactivator 2 Neighboring gene STARR-seq mESC enhancer starr_11738 Neighboring gene STARR-positive B cell enhancer ABC_E8000 Neighboring gene STARR-positive B cell enhancer ABC_E4684 Neighboring gene STARR-seq mESC enhancer starr_11739 Neighboring gene STARR-positive B cell enhancer ABC_E4685 Neighboring gene fucosidase, alpha-L- 1, tissue Neighboring gene STARR-positive B cell enhancer ABC_E4686 Neighboring gene 3-hydroxy-3-methylglutaryl-Coenzyme A lyase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Anti-Tumorigenic Role of Cannabinoid Receptor 2 in Non-Melanoma Skin Cancer. Iden JA, et al. Int J Mol Sci, 2023 Apr 24. PMID 37175480, Free PMC Article
    2. Cannabinoid CB2 receptors modulate alcohol induced behavior, and neuro-immune dysregulation in mice. Kibret BG, et al. Behav Brain Res, 2023 Jun 25. PMID 37061199
    3. Structural basis of selective cannabinoid CB(2) receptor activation. Li X, et al. Nat Commun, 2023 Mar 15. PMID 36922494, Free PMC Article
    4. Role of CB2 cannabinoid receptor in the development of food addiction in male mice. García-Blanco A, et al. Neurobiol Dis, 2023 Apr. PMID 36775043
    5. CB2R activation ameliorates late adolescent chronic alcohol exposure-induced anxiety-like behaviors during withdrawal by preventing morphological changes and suppressing NLRP3 inflammasome activation in prefrontal cortex microglia in mice. Li J, et al. Brain Behav Immun, 2023 May. PMID 36754245

    See all (332) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Role of the CB2 Cannabinoid Receptor in the Regulation of Food Intake: A Systematic Review.
      Title: Role of the CB2 Cannabinoid Receptor in the Regulation of Food Intake: A Systematic Review.
    2. The role of cannabinoid receptor 2 in bone remodeling during orthodontic tooth movement.
      Title: The role of cannabinoid receptor 2 in bone remodeling during orthodontic tooth movement.
    3. Cannabinoid receptor 2 alleviates sepsis-associated acute lung injury by modulating maturation of dendritic cells.
      Title: Cannabinoid receptor 2 alleviates sepsis-associated acute lung injury by modulating maturation of dendritic cells.
    4. Specific Activation of CB2R Ameliorates Psoriasis-Like Skin Lesions by Inhibiting Inflammation and Oxidative Stress.
      Title: Specific Activation of CB2R Ameliorates Psoriasis-Like Skin Lesions by Inhibiting Inflammation and Oxidative Stress.
    5. Conditional deletion of CB2 cannabinoid receptors from peripheral sensory neurons eliminates CB2-mediated antinociceptive efficacy in a mouse model of carrageenan-induced inflammatory pain.
      Title: Conditional deletion of CB2 cannabinoid receptors from peripheral sensory neurons eliminates CB2-mediated antinociceptive efficacy in a mouse model of carrageenan-induced inflammatory pain.
    6. The Anti-Tumorigenic Role of Cannabinoid Receptor 2 in Non-Melanoma Skin Cancer.
      Title: The Anti-Tumorigenic Role of Cannabinoid Receptor 2 in Non-Melanoma Skin Cancer.
    7. CB2R activation ameliorates late adolescent chronic alcohol exposure-induced anxiety-like behaviors during withdrawal by preventing morphological changes and suppressing NLRP3 inflammasome activation in prefrontal cortex microglia in mice.
      Title: CB2R activation ameliorates late adolescent chronic alcohol exposure-induced anxiety-like behaviors during withdrawal by preventing morphological changes and suppressing NLRP3 inflammasome activation in prefrontal cortex microglia in mice.
    8. The Anti-Tumorigenic Role of Cannabinoid Receptor 2 in Colon Cancer: A Study in Mice and Humans.
      Title: The Anti-Tumorigenic Role of Cannabinoid Receptor 2 in Colon Cancer: A Study in Mice and Humans.
    9. Role of CB2 cannabinoid receptor in the development of food addiction in male mice.
      Title: Role of CB2 cannabinoid receptor in the development of food addiction in male mice.
    10. Peripheral sensory neuron CB2 cannabinoid receptors are necessary for both CB2-mediated antinociceptive efficacy and sparing of morphine tolerance in a mouse model of anti-retroviral toxic neuropathy.
      Title: Peripheral sensory neuron CB2 cannabinoid receptors are necessary for both CB2-mediated antinociceptive efficacy and sparing of morphine tolerance in a mouse model of anti-retroviral toxic neuropathy.
    Submit: New GeneRIF Correction See all GeneRIFs (237)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (8)  1 citation
    • Endonuclease-mediated (4) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cannabinoid receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cannabinoid receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within leukocyte chemotaxis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of action potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of mast cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of synaptic transmission, GABAergic ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in trans-synaptic signaling by endocannabinoid, modulating synaptic transmission EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in trans-synaptic signaling by endocannabinoid, modulating synaptic transmission IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extrinsic component of cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cannabinoid receptor 2
    Names
    cannabinoid receptor 2 (macrophage)
    cannabinoid receptor 2 (spleen)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305278.1 → NP_001292207.1  cannabinoid receptor 2

      See identical proteins and their annotated locations for NP_001292207.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK036658, AK134109, FJ357035
      Consensus CDS
      CCDS18793.1
      UniProtKB/Swiss-Prot
      P47936, Q544H5
      Related
      ENSMUSP00000069957.4, ENSMUST00000068830.4
      Conserved Domains (2) summary
      pfam00001
      Location:50 → 299
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:42 → 314
      7tm_4; Olfactory receptor

    2. NM_009924.4 → NP_034054.3  cannabinoid receptor 2

      See identical proteins and their annotated locations for NP_034054.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK036658, AK037898, AK134109, AL672076, FJ357034, X86405
      Consensus CDS
      CCDS18793.1
      UniProtKB/Swiss-Prot
      P47936, Q544H5
      Related
      ENSMUSP00000095454.3, ENSMUST00000097843.9
      Conserved Domains (2) summary
      pfam00001
      Location:50 → 299
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:42 → 314
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      135622500..135647530
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47936.1 GenPept UniProtKB/Swiss-Prot:P47936

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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