Timp2 tissue inhibitor of metalloproteinase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Timp2provided by MGI
Official Full Name: tissue inhibitor of metalloproteinase 2provided by MGI
Primary source: MGI:MGI:98753
See related: Ensembl:ENSMUSG00000017466 AllianceGenome:MGI:98753
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Timp-2; D11Bwg1104e
Summary: Enables enzyme activator activity; integrin binding activity; and metalloendopeptidase inhibitor activity. Acts upstream of or within several processes, including negative regulation of cell population proliferation; regulation of MAPK cascade; and regulation of neuron differentiation. Located in basement membrane and cell surface. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and skeletal system. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human TIMP2 (TIMP metallopeptidase inhibitor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in bladder adult (RPKM 237.6), lung adult (RPKM 168.3) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 83.09 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (118191887..118246237, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (118301061..118355411, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TIMP2 ameliorates blood-brain barrier disruption in traumatic brain injury by inhibiting Src-dependent VE-cadherin internalization.
Title: TIMP2 ameliorates blood-brain barrier disruption in traumatic brain injury by inhibiting Src-dependent VE-cadherin internalization.
The Histone Methyltransferase SETDB2 Modulates Tissue Inhibitors of Metalloproteinase-Matrix Metalloproteinase Activity During Abdominal Aortic Aneurysm Development.
Title: The Histone Methyltransferase SETDB2 Modulates Tissue Inhibitors of Metalloproteinase-Matrix Metalloproteinase Activity During Abdominal Aortic Aneurysm Development.
Noncanonical Activity of Tissue Inhibitor of Metalloproteinases 2 (TIMP2) Improves Cognition and Synapse Density in Aging.
Title: Noncanonical Activity of Tissue Inhibitor of Metalloproteinases 2 (TIMP2) Improves Cognition and Synapse Density in Aging.
TIMP2 facilitates CIRI through activating NLRP3-mediated pyroptosis.
Title: TIMP2 facilitates CIRI through activating NLRP3-mediated pyroptosis.
Bioorthogonal PEGylation Prolongs the Elimination Half-Life of N-TIMP2 While Retaining MMP Inhibition.
Title: Bioorthogonal PEGylation Prolongs the Elimination Half-Life of N-TIMP2 While Retaining MMP Inhibition.
TIMP2 mediates endoplasmic reticulum stress contributing to sepsis-induced acute kidney injury.
Title: TIMP2 mediates endoplasmic reticulum stress contributing to sepsis-induced acute kidney injury.
TIMP-2 suppresses tumor growth and metastasis in murine model of triple-negative breast cancer.
Title: TIMP-2 suppresses tumor growth and metastasis in murine model of triple-negative breast cancer.
Current study elucidated the distinct nature of the inhibitory effect on IS as a result of overexpressed miR-410 whereby the conferral of neuroprotection was observed in oxidative stress-induced apoptosis post IS through the TIMP2-dependent repression of the MAPK pathway in mice.
Title: MicroRNA-410 inhibition of the TIMP2-dependent MAPK pathway confers neuroprotection against oxidative stress-induced apoptosis after ischemic stroke in mice.
Glycosaminoglycan, CaG can strengthen ECM by increasing activity of TIMP-2 and adhesion activity on collagen known to inhibit changes of extracellular matrix, leading to tumor cell invasion and progression
Title: Anti-cancer effect of dung beetle glycosaminoglycans on melanoma.
the protein expression levels of TIMP-2 and PBEF in cloned placentae, were examined.
Title: Aberrant Expression of TIMP-2 and PBEF Genes in the Placentae of Cloned Mice Due to Epigenetic Reprogramming Error.

Submit: New GeneRIF Correction See all GeneRIFs (52)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2) 1 citation
Endonuclease-mediated (4)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:224264

Timp2 (e-PCR), detects polymorphism
- UniSTS:265761

Timp2 (e-PCR), detects polymorphism
- UniSTS:259384

Ddc8 (e-PCR), detects polymorphism
- UniSTS:532065

Timp2 (e-PCR), detects polymorphism
- UniSTS:532066

Timp2 (e-PCR), detects polymorphism
- UniSTS:532067

Timp2 (e-PCR), detects polymorphism
- UniSTS:532068

Timp2 (e-PCR), detects polymorphism
- UniSTS:532069

Timp2 (e-PCR), detects polymorphism
- UniSTS:532070

X62622 (e-PCR)
- UniSTS:125831

D11Bwg1104e (e-PCR), detects polymorphism
- UniSTS:141723

Timp2 (e-PCR), detects polymorphism
- UniSTS:265630

Timp2 (e-PCR), detects polymorphism
- UniSTS:144626

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables enzyme inhibitor activity	IEA Inferred from Electronic Annotation more info
enables integrin binding	IDA Inferred from Direct Assay more info	PubMed
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase inhibitor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables metalloendopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables metalloendopeptidase inhibitor activity	TAS Traceable Author Statement more info	PubMed
enables molecular function inhibitor activity	ISO Inferred from Sequence Orthology more info
enables peptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protease binding	IBA Inferred from Biological aspect of Ancestor more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to organic substance	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of Ras protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of membrane protein ectodomain proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of metallopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of proteolysis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of Rap protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to cytokine	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to hormone	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: metalloproteinase inhibitor 2

Names: tissue inhibitor of metalloproteinases 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011594.3 → NP_035724.2 metalloproteinase inhibitor 2 precursor

See identical proteins and their annotated locations for NP_035724.2

Status: VALIDATED

Source sequence(s)

AK032818, AK081522, BQ030835

Consensus CDS

CCDS25699.1

UniProtKB/TrEMBL

Q6PI17, Q8BSJ3

Related

ENSMUSP00000017610.4, ENSMUST00000017610.11

Conserved Domains (1) summary

cd03585
Location:27 → 209

NTR_TIMP; NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...