Cacna1b calcium voltage-gated channel subunit alpha1 B [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Cacna1bprovided by RGD
Full Name: calcium voltage-gated channel subunit alpha1 Bprovided by RGD
Primary source: RGD:628852
See related: Ensembl:ENSRNOG00000004560 AllianceGenome:RGD:628852
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: BIII
Summary: Enables high voltage-gated calcium channel activity; protein phosphatase 2A binding activity; and voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels. Involved in several processes, including positive regulation of neurotransmitter secretion; response to ethanol; and response to testosterone. Located in several cellular components, including axon terminus; dendritic shaft; and neuronal cell body. Part of protein-containing complex. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Human ortholog(s) of this gene implicated in Lambert-Eaton myasthenic syndrome and dystonia 23. Orthologous to human CACNA1B (calcium voltage-gated channel subunit alpha1 B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 87.3) See more
Orthologs: human mouse all
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Genomic context

Location:: 3p13

Exon count:: 49

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (27779133..27944292, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (7380892..7546104, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (1740026..1924959, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

High-voltage long-duration pulsed radiofrequency attenuates neuropathic pain in CCI rats by inhibiting Cav2.2 in spinal dorsal horn and dorsal root ganglion.
Title: High-voltage long-duration pulsed radiofrequency attenuates neuropathic pain in CCI rats by inhibiting Cav2.2 in spinal dorsal horn and dorsal root ganglion.
CaV2.2 (N-type) voltage-gated calcium channels are activated by SUMOylation pathways.
Title: Ca(V)2.2 (N-type) voltage-gated calcium channels are activated by SUMOylation pathways.
Dynamic CRMP2 Regulation of CaV2.2 in the Prefrontal Cortex Contributes to the Reinstatement of Cocaine Seeking.
Title: Dynamic CRMP2 Regulation of CaV2.2 in the Prefrontal Cortex Contributes to the Reinstatement of Cocaine Seeking.
interacting PIP2 charges not only underly the maintenance of the channel-current but also that charge screening of PIP2 by itself unveils the voltage-independent features of CaV2.2 channels in SCG neurons
Title: Maintenance of Ca(V)2.2 channel-current by PIP(2) unveiled by neomycin in sympathetic neurons of the rat.
This study provides new insights into the roles of the MOR full-length C-terminal variants in modulating Cav2.2 channel isoform activities.
Title: Differential regulation of Cav2.2 channel exon 37 variants by alternatively spliced μ-opioid receptors.
A decrease in N-type Ca(2+) channels in atrioventricular ganglion neurons attenuates vagal control of ventricular myocardium, thereby initiating ventricular arrhythmias.
Title: Reduced N-Type Ca(2+) Channels in Atrioventricular Ganglion Neurons Are Involved in Ventricular Arrhythmogenesis.
the voltage-gated N-type Ca(2+) channel (CaV2.2) is the The voltage sensor triggering Ca(2+)-independent but voltage-dependent secretion, the SNARE complex functions as the vesicle fusion machinery, the "synprint" of CaV2.2 serves as a linker between the voltage sensor and the fusion machinery, and ATP is a cargo of Ca(2+)-independent but voltage-dependent secretion vesicles.
Title: Ca(V)2.2 Gates Calcium-Independent but Voltage-Dependent Secretion in Mammalian Sensory Neurons.
N-type voltage-gated calcium channel inhibition appears to be the mechanism by which MOR activation inhibits the exercise pressor reflex in decerebrate rats.
Title: µ-Opioid receptors inhibit the exercise pressor reflex by closing N-type calcium channels but not by opening GIRK channels in rats.
Cav 1.2 and Cav 2.2 expression increased in acute necrotizing pancreatitis. The [Ca2+]i level, which is mediated by Cav 1.2 and Cav 2.2 expression, is directly regulated by ghrelin in pancreatic acinar cells, and serum ghrelin levels may be involved in the severity of acute pancreatitis.
Title: Cav 1.2 and Cav 2.2 expression is regulated by different endogenous ghrelin levels in pancreatic acinar cells during acute pancreatitis.
Both alpha2delta-1 and alpha2delta-2 seemed to promote CaV2.2 displacement by recombinant channel expression, while alpha2delta-3 appeared to protect CaV2.2 from displacement.
Title: Ca(V)2 channel subtype expression in rat sympathetic neurons is selectively regulated by α(2)δ subunits.

Submit: New GeneRIF Correction See all GeneRIFs (42)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10Wox55 (e-PCR)
- UniSTS:518951

AW060892 (e-PCR)
- UniSTS:178582

AW050276 (e-PCR)
- UniSTS:178583

RH138323 (e-PCR)
- UniSTS:220410

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables high voltage-gated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables high voltage-gated calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables high voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase 2A binding	IPI Inferred from Physical Interaction more info	PubMed
enables voltage-gated calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	EXP Inferred from Experiment more info	PubMed
enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium ion import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neurotransmitter secretion	ISO Inferred from Sequence Orthology more info
involved_in optic nerve development	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of blood pressure	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium-dependent activation of synaptic vesicle fusion	EXP Inferred from Experiment more info	PubMed
involved_in regulation of calcium-dependent activation of synaptic vesicle fusion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of heart contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of presynaptic cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in response to amyloid-beta	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to pain	ISO Inferred from Sequence Orthology more info
involved_in response to testosterone	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	EXP Inferred from Experiment more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendritic shaft	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in neuron projection terminus	ISO Inferred from Sequence Orthology more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in stereocilium membrane	ISO Inferred from Sequence Orthology more info
part_of voltage-gated calcium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated calcium channel complex	IEA Inferred from Electronic Annotation more info
part_of voltage-gated calcium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: voltage-dependent N-type calcium channel subunit alpha-1B

Names: brain calcium channel III; calcium channel, L type, alpha-1 polypeptide; calcium channel, voltage-dependent, N type, alpha 1B subunit; voltage gated N-type calcium channel Ca(v)2.2; voltage-dependent N-type calcium channel subunit alpha-1B-like; voltage-gated calcium channel subunit alpha Cav2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001195199.2 → NP_001182128.1 voltage-dependent N-type calcium channel subunit alpha-1B isoform 1

See identical proteins and their annotated locations for NP_001182128.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I6GME3, E1AW38

Conserved Domains (3) summary

pfam00520
Location:1506 → 1737

Ion_trans; Ion transport protein

pfam08763
Location:1811 → 1885

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1745 → 1809

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
NM_001413253.1 → NP_001400182.1 voltage-dependent N-type calcium channel subunit alpha-1B isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I5ZZF2

Related

ENSRNOP00000083167.1, ENSRNOT00000108914.1
NM_147141.3 → NP_671482.1 voltage-dependent N-type calcium channel subunit alpha-1B isoform 2

See identical proteins and their annotated locations for NP_671482.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I6GME3, O89089

Conserved Domains (3) summary

pfam00520
Location:1485 → 1716

Ion_trans; Ion transport protein

pfam08763
Location:1790 → 1864

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1724 → 1788

GPHH; Voltage-dependent L-type calcium channel, IQ-associated

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

27779133..27944292 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063283169.1 → XP_063139239.1 voltage-dependent N-type calcium channel subunit alpha-1B isoform X7
XM_063283167.1 → XP_063139237.1 voltage-dependent N-type calcium channel subunit alpha-1B isoform X5

UniProtKB/TrEMBL

A6JSY9
XM_017591505.3 → XP_017446994.1 voltage-dependent N-type calcium channel subunit alpha-1B isoform X3

UniProtKB/TrEMBL

A0A8I6GME3

Related

ENSRNOP00000044223.5
XM_063283168.1 → XP_063139238.1 voltage-dependent N-type calcium channel subunit alpha-1B isoform X6
XM_063283166.1 → XP_063139236.1 voltage-dependent N-type calcium channel subunit alpha-1B isoform X4
XM_063283165.1 → XP_063139235.1 voltage-dependent N-type calcium channel subunit alpha-1B isoform X2
XM_006233574.5 → XP_006233636.1 voltage-dependent N-type calcium channel subunit alpha-1B isoform X1

UniProtKB/TrEMBL

A0A8I6GME3

Related

ENSRNOP00000006162.6

Conserved Domains (3) summary

pfam00520
Location:1507 → 1736

Ion_trans; Ion transport protein

pfam08763
Location:1810 → 1884

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1744 → 1808

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_063283170.1 → XP_063139240.1 voltage-dependent N-type calcium channel subunit alpha-1B isoform X9
XM_039104390.2 → XP_038960318.2 voltage-dependent N-type calcium channel subunit alpha-1B isoform X8