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    SEC11C SEC11 homolog C, signal peptidase complex subunit [ Homo sapiens (human) ]

    Gene ID: 90701, updated on 5-Mar-2024

    Summary

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    Official Symbol
    SEC11Cprovided by HGNC
    Official Full Name
    SEC11 homolog C, signal peptidase complex subunitprovided by HGNC
    Primary source
    HGNC:HGNC:23400
    See related
    Ensembl:ENSG00000166562 AllianceGenome:HGNC:23400
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SPC21; SPCS4C; SEC11L3
    Summary
    Predicted to enable peptidase activity. Predicted to be involved in signal peptide processing. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of signal peptidase complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in prostate (RPKM 109.5), thyroid (RPKM 61.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    18q21.32
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (59139884..59158832)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (59341164..59360112)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (56807116..56826064)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 532 Neighboring gene RNA, U2 small nuclear 69, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:56635193-56636106 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr18:56650842-56652041 Neighboring gene O-acyltransferase like, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9489 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:56716067-56717037 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:56717038-56718007 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr18:56729547-56730746 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13406 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13407 Neighboring gene NANOG hESC enhancer GRCh37_chr18:56758336-56758837 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9490 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9491 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13409 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13408 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13410 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13411 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13412 Neighboring gene signal recognition particle 19kDa pseudogene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr18:56855703-56856902 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:56886610-56887224 Neighboring gene gastrin releasing peptide

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Signal peptidase 21 suppresses cell proliferation, migration, and invasion via the PTEN-PI3K/Akt signaling pathway in lung adenocarcinoma. Zhang N, et al. PeerJ, 2022. PMID 36275477, Free PMC Article
    2. Signal peptidase complex 18, encoded by SEC11A, contributes to progression via TGF-α secretion in gastric cancer. Oue N, et al. Oncogene, 2014 Jul 24. PMID 23995782
    3. Two subunits of the canine signal peptidase complex are homologous to yeast SEC11 protein. Shelness GS, et al. J Biol Chem, 1990 Jun 5. PMID 2188978
    4. Structure of the human signal peptidase complex reveals the determinants for signal peptide cleavage. Liaci AM, et al. Mol Cell, 2021 Oct 7. PMID 34388369
    5. The role of assembly in insulin's biosynthesis. Dodson G, et al. Curr Opin Struct Biol, 1998 Apr. PMID 9631292

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Signal peptidase 21 suppresses cell proliferation, migration, and invasion via the PTEN-PI3K/Akt signaling pathway in lung adenocarcinoma.
      Title: Signal peptidase 21 suppresses cell proliferation, migration, and invasion via the PTEN-PI3K/Akt signaling pathway in lung adenocarcinoma.
    2. Structure of the human signal peptidase complex reveals the determinants for signal peptide cleavage.
      Title: Structure of the human signal peptidase complex reveals the determinants for signal peptide cleavage.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in signal peptide processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal peptide processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		  
    part_of signal peptidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of signal peptidase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of signal peptidase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    signal peptidase complex catalytic subunit SEC11C
    Names
    SEC11-like 3
    SEC11-like protein 3
    SPase 21 kDa subunit
    microsomal signal peptidase 21 kDa subunit
    signal peptidase complex 21
    NP_001294870.1
    NP_150596.1
    XP_011524562.1
    XP_054175301.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001307941.2 → NP_001294870.1  signal peptidase complex catalytic subunit SEC11C isoform 2

      See identical proteins and their annotated locations for NP_001294870.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR, and lacks an alternate exon in the 3' coding region resulting in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      BM760252, BM789622, BQ417397
      Consensus CDS
      CCDS77193.1
      UniProtKB/TrEMBL
      B4DI03, K7EJQ7
      Related
      ENSP00000465281.1, ENST00000588875.2
      Conserved Domains (1) summary
      cl10465
      Location:34 → 134
      Peptidase_S24_S26; The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the ...

    2. NM_033280.4 → NP_150596.1  signal peptidase complex catalytic subunit SEC11C isoform 1

      See identical proteins and their annotated locations for NP_150596.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF212233, BM789622
      Consensus CDS
      CCDS11970.1
      UniProtKB/Swiss-Prot
      B2RAA3, Q9BY50
      UniProtKB/TrEMBL
      B4DI03
      Related
      ENSP00000468633.1, ENST00000587834.6
      Conserved Domains (1) summary
      cl10465
      Location:34 → 167
      Peptidase_S24_S26; The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      59139884..59158832
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011526260.4 → XP_011524562.1  signal peptidase complex catalytic subunit SEC11C isoform X1

      Conserved Domains (1) summary
      cl10465
      Location:31 → 164
      Peptidase_S24_S26; The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      59341164..59360112
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054319326.1 → XP_054175301.1  signal peptidase complex catalytic subunit SEC11C isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BY50.3 GenPept UniProtKB/Swiss-Prot:Q9BY50

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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