pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pik3c3provided by ZNC
Official Full Name: phosphatidylinositol 3-kinase, catalytic subunit type 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-050410-13
See related: Ensembl:ENSDARG00000054829 AllianceGenome:ZFIN:ZDB-GENE-050410-13
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:7147158; wu:fc13g06; wu:fz51e12; zgc:112016; zgc:113009
Summary: Predicted to enable 1-phosphatidylinositol-3-kinase activity. Predicted to be involved in several processes, including autophagosome assembly; phosphatidylinositol-3-phosphate biosynthetic process; and phosphatidylinositol-mediated signaling. Predicted to act upstream of or within phosphorylation. Predicted to be part of phosphatidylinositol 3-kinase complex, class III, type I and phosphatidylinositol 3-kinase complex, class III, type II. Predicted to be active in several cellular components, including endosome; peroxisome; and phagophore assembly site. Used to study inflammatory bowel disease. Orthologous to human PIK3C3 (phosphatidylinositol 3-kinase catalytic subunit type 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (24593255..24621728, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (24322098..24350539, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results not only reveal a role of PIK3C3 in gut homeostasis, but also provide a zebrafish inflammatory bowel disease model.
Title: Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

AI626336 (e-PCR)
- UniSTS:206138

fc13g06.x1 (e-PCR)
- UniSTS:192650

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-3-kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagy of peroxisome	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphatidylinositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol-3-phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in midbody	IEA Inferred from Electronic Annotation more info
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in phagophore assembly site	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphatidylinositol 3-kinase complex, class III, type I	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphatidylinositol 3-kinase complex, class III, type II	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: phosphatidylinositol 3-kinase catalytic subunit type 3

Names: phosphoinositide-3-kinase, class 3

NP_001315462.1

EC 2.7.1.137

XP_021333200.1

EC 2.7.1.137

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001328533.1 → NP_001315462.1 phosphatidylinositol 3-kinase catalytic subunit type 3

Status: VALIDATED

Source sequence(s)

BX510349, EH542626, EH563762

UniProtKB/TrEMBL

A0A8M1P518, F1Q9F3

Related

ENSDARP00000092039.3, ENSDART00000101265.5

Conserved Domains (3) summary

cd08397
Location:25 → 185

C2_PI3K_class_III; C2 domain present in class III phosphatidylinositol 3-kinases (PI3Ks)

cd00870
Location:282 → 494

PI3Ka_III; Phosphoinositide 3-kinase (PI3K) class III, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3Ks class III ...

cd00896
Location:530 → 874

PI3Kc_III; Catalytic domain of Class III Phosphoinositide 3-kinase

RNA

NR_137316.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

BX510349

Related

ENSDART00000127155.4

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007118.7 Reference GRCz11 Primary Assembly

Range

24593255..24621728 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021477525.1 → XP_021333200.1 phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1

UniProtKB/TrEMBL

A0A8M9QGZ6

Conserved Domains (3) summary

cd08397
Location:25 → 194

C2_PI3K_class_III; C2 domain present in class III phosphatidylinositol 3-kinases (PI3Ks)

cd00870
Location:291 → 503

PI3Ka_III; Phosphoinositide 3-kinase (PI3K) class III, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3Ks class III ...

cd00896
Location:539 → 883

PI3Kc_III; Catalytic domain of Class III Phosphoinositide 3-kinase

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001017550.2: Suppressed sequence

Description

NM_001017550.2: This RefSeq was removed because currently there is support for the transcript but not for the protein.