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    Ddx11 DEAD/H box helicase 11 [ Mus musculus (house mouse) ]

    Gene ID: 320209, updated on 9-May-2024

    Summary

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    Official Symbol
    Ddx11provided by MGI
    Official Full Name
    DEAD/H box helicase 11provided by MGI
    Primary source
    MGI:MGI:2443590
    See related
    Ensembl:ENSMUSG00000035842 AllianceGenome:MGI:2443590
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CHL1; KRG2; CHLR1; essa15a; 4732462I11Rik
    Summary
    Predicted to enable several functions, including 5'-3' DNA helicase activity; ATP-dependent activity, acting on RNA; and nucleic acid binding activity. Predicted to be involved in DNA duplex unwinding and establishment of sister chromatid cohesion. Predicted to act upstream of or within DNA repair and DNA replication. Predicted to be located in several cellular components, including microtubule cytoskeleton; midbody; and nuclear lumen. Predicted to be part of Ctf18 RFC-like complex. Predicted to be active in nucleus. Is expressed in allantois; embryo; placenta; and yolk sac endoderm. Human ortholog(s) of this gene implicated in Warsaw breakage syndrome. Orthologous to several human genes including DDX11 (DEAD/H-box helicase 11). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 7.2), limb E14.5 (RPKM 5.7) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 E1.1; 17 35.26 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (66430508..66459169)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (66123513..66152174)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase core subunit V2 Neighboring gene predicted gene, 23264 Neighboring gene STARR-seq mESC enhancer starr_43041 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:66456304-66456487 Neighboring gene STARR-positive B cell enhancer ABC_E10966 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:66460812-66460921 Neighboring gene WASH complex subunit 1 Neighboring gene STARR-positive B cell enhancer ABC_E7552 Neighboring gene STARR-seq mESC enhancer starr_43043 Neighboring gene STARR-seq mESC enhancer starr_43044 Neighboring gene STARR-seq mESC enhancer starr_43045 Neighboring gene putative sperm motility kinase W Neighboring gene predicted gene, 20742

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of ChlR1 helicase in mouse causes lethality due to the accumulation of aneuploid cells generated by cohesion defects and placental malformation. Inoue A, et al. Cell Cycle, 2007 Jul 1. PMID 17611414
    2. Mammalian ChlR1 has a role in heterochromatin organization. Inoue A, et al. Exp Cell Res, 2011 Oct 15. PMID 21854770, Free PMC Article
    3. The ENU-induced cetus mutation reveals an essential role of the DNA helicase DDX11 for mesoderm development during early mouse embryogenesis. Cota CD, et al. Dev Dyn, 2012 Aug. PMID 22678773
    4. Analysis of mouse embryonic patterning and morphogenesis by forward genetics. García-García MJ, et al. Proc Natl Acad Sci U S A, 2005 Apr 26. PMID 15755804, Free PMC Article
    5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ChlR1 is essential for embryonic development and the prevention of aneuploidy in mammals.
      Title: Loss of ChlR1 helicase in mouse causes lethality due to the accumulation of aneuploid cells generated by cohesion defects and placental malformation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC90809

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 5'-3' DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent activity, acting on DNA ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP-dependent activity, acting on RNA ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA replication origin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables G-quadruplex DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables single-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables triplex DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA duplex unwinding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment of sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleobase-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Ctf18 RFC-like complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ATP-dependent DNA helicase DDX11
    Names
    DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae)
    probable ATP-dependent RNA helicase DDX11
    NP_001003919.1
    NP_001335221.1
    XP_006524472.1
    XP_006524473.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003919.2 → NP_001003919.1  ATP-dependent DNA helicase DDX11 isoform 1

      See identical proteins and their annotated locations for NP_001003919.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate in-frame splice site in the 5' coding region compared to variant 2. The encoded isoform (1) is shorter than isoform 2.
      Source sequence(s)
      BC079656, CT025671
      Consensus CDS
      CCDS28945.1
      UniProtKB/TrEMBL
      A0A2Y9CZM3
      Related
      ENSMUSP00000130440.3, ENSMUST00000163605.3
      Conserved Domains (3) summary
      TIGR00604
      Location:199 → 863
      rad3; DNA repair helicase (rad3)
      pfam13307
      Location:664 → 853
      Helicase_C_2; Helicase C-terminal domain
      cl21455
      Location:22 → 408
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001348292.1 → NP_001335221.1  ATP-dependent DNA helicase DDX11 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
      Source sequence(s)
      AK152868, BC079656, CT025671
      Consensus CDS
      CCDS89137.1
      UniProtKB/Swiss-Prot
      A0A286YDJ5, Q6AXC6
      Related
      ENSMUSP00000153436.2, ENSMUST00000224497.2
      Conserved Domains (1) summary
      TIGR00604
      Location:225 → 889
      rad3; DNA repair helicase (rad3)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      66430508..66459169
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524410.5 → XP_006524473.1  ATP-dependent DNA helicase DDX11 isoform X2

      Conserved Domains (1) summary
      cl28899
      Location:22 → 434
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

    2. XM_006524409.4 → XP_006524472.1  ATP-dependent DNA helicase DDX11 isoform X1

      See identical proteins and their annotated locations for XP_006524472.1

      UniProtKB/Swiss-Prot
      A0A286YDJ5, Q6AXC6
      Conserved Domains (1) summary
      TIGR00604
      Location:225 → 889
      rad3; DNA repair helicase (rad3)

    RNA

    1. XR_003952132.2 RNA Sequence

    2. XR_385336.5 RNA Sequence

      Related
      ENSMUST00000225687.2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AXC6.2 GenPept UniProtKB/Swiss-Prot:Q6AXC6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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