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    Mybpc2 myosin binding protein C, fast-type [ Mus musculus (house mouse) ]

    Gene ID: 233199, updated on 12-May-2024

    Summary

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    Official Symbol
    Mybpc2provided by MGI
    Official Full Name
    myosin binding protein C, fast-typeprovided by MGI
    Primary source
    MGI:MGI:1336170
    See related
    Ensembl:ENSMUSG00000038670 AllianceGenome:MGI:1336170
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to be a structural constituent of cytoskeleton. Acts upstream of or within muscle contraction. Predicted to be located in cytoskeleton. Is expressed in diaphragm; extensor digitorum longus; hindlimb; rectus femoris; and soleus. Orthologous to human MYBPC2 (myosin binding protein C2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in mammary gland adult (RPKM 39.2) and heart adult (RPKM 2.0) See more
    Orthologs
    human all
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    Genomic context

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    See Mybpc2 in Genome Data Viewer
    Location:
    7 B3; 7 28.83 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44151123..44174093, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44501699..44524715, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 5430431A17 gene Neighboring gene STARR-seq mESC enhancer starr_18800 Neighboring gene ER membrane protein complex subunit 10 Neighboring gene golgi associated RAB2 interactor 5A Neighboring gene STARR-positive B cell enhancer ABC_E10437 Neighboring gene Spi-B transcription factor (Spi-1/PU.1 related) Neighboring gene polymerase (DNA directed), delta 1, catalytic subunit Neighboring gene microRNA 7053

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Fast skeletal myosin-binding protein-C regulates fast skeletal muscle contraction. Song T, et al. Proc Natl Acad Sci U S A, 2021 Apr 27. PMID 33888578, Free PMC Article
    2. Cleavage of poly(ADP-ribose) polymerase: a sensitive parameter to study cell death. Duriez PJ, et al. Biochem Cell Biol, 1997. PMID 9493956
    3. Fast and slow skeletal myosin binding protein-C and aging. Perazza LR, et al. Geroscience, 2023 Apr. PMID 36409445, Free PMC Article
    4. Differential expression of C-protein isoforms in developing and degenerating mouse striated muscles. Kurasawa M, et al. Muscle Nerve, 1999 Feb. PMID 10024132
    5. Isoform transitions of the myosin binding protein C family in developing human and mouse muscles: lack of isoform transcomplementation in cardiac muscle. Gautel M, et al. Circ Res, 1998 Jan 9-23. PMID 9440711

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fast and slow skeletal myosin binding protein-C and aging.
      Title: Fast and slow skeletal myosin binding protein-C and aging.
    2. Fast skeletal myosin-binding protein-C regulates fast skeletal muscle contraction.
      Title: Fast skeletal myosin-binding protein-C regulates fast skeletal muscle contraction.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC28149

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of cytoskeleton TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cytoskeleton organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within muscle contraction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in sarcomere organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in M band IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in myosin filament IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    myosin-binding protein C, fast-type
    Names
    fast MyBP-C
    fast-type C-protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_146189.3 → NP_666301.2  myosin-binding protein C, fast-type

      See identical proteins and their annotated locations for NP_666301.2

      Status: VALIDATED

      Source sequence(s)
      AK029282, AK132563, CK787764
      Consensus CDS
      CCDS52233.1
      UniProtKB/Swiss-Prot
      Q5XKE0, Q8C109, Q8K2V0
      Related
      ENSMUSP00000130127.3, ENSMUST00000165208.4
      Conserved Domains (7) summary
      cd00096
      Location:1062 → 1127
      Ig; Immunoglobulin domain
      cd05748
      Location:853 → 924
      Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
      cd05894
      Location:545 → 630
      Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
      smart00410
      Location:548 → 630
      IG_like; Immunoglobulin like
      cd00063
      Location:634 → 720
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1043 → 1132
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:278 → 325
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      44151123..44174093 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XKE0.1 GenPept UniProtKB/Swiss-Prot:Q5XKE0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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