Hmox1 heme oxygenase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hmox1provided by MGI
Official Full Name: heme oxygenase 1provided by MGI
Primary source: MGI:MGI:96163
See related: Ensembl:ENSMUSG00000005413 AllianceGenome:MGI:96163
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HO1; HO-1; Hmox; Hemox; Hsp32; D8Wsu38e
Summary: Predicted to enable several functions, including heme binding activity; heme oxygenase (decyclizing) activity; and protein homodimerization activity. Acts upstream of or within several processes, including cellular response to cisplatin; cellular response to metal ion; and regulation of macroautophagy. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study hemochromatosis and malaria. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); factor VIII deficiency; lung disease (multiple); and sickle cell anemia. Orthologous to human HMOX1 (heme oxygenase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in placenta adult (RPKM 123.6), spleen adult (RPKM 121.0) and 13 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 8 35.59 cM; 8 C1

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (75820246..75827221)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (75093618..75100593)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regional variations in allergen-induced airway inflammation correspond to changes in soluble guanylyl cyclase heme and expression of heme oxygenase-1.
Title: Regional variations in allergen-induced airway inflammation correspond to changes in soluble guanylyl cyclase heme and expression of heme oxygenase-1.
Melatonin MT1 receptors regulate the Sirt1/Nrf2/Ho-1/Gpx4 pathway to prevent alpha-synuclein-induced ferroptosis in Parkinson's disease.
Title: Melatonin MT1 receptors regulate the Sirt1/Nrf2/Ho-1/Gpx4 pathway to prevent α-synuclein-induced ferroptosis in Parkinson's disease.
Heme oxygenase-1 alleviates allergic airway inflammation by suppressing NF-kappaB-mediated pyroptosis of bronchial epithelial cells.
Title: Heme oxygenase-1 alleviates allergic airway inflammation by suppressing NF-κB-mediated pyroptosis of bronchial epithelial cells.
Microglial FoxO3a deficiency ameliorates ferroptosis-induced brain injury of intracerebral haemorrhage via regulating autophagy and heme oxygenase-1.
Title: Microglial FoxO3a deficiency ameliorates ferroptosis-induced brain injury of intracerebral haemorrhage via regulating autophagy and heme oxygenase-1.
Inhibition of heme oxygenase 1 alleviates thoracic aortic aneurysm via restoration of extracellular matrix.
Title: Inhibition of heme oxygenase 1 alleviates thoracic aortic aneurysm via restoration of extracellular matrix.
HO-1-Mediated Autophagic Restoration Protects Lens Epithelial Cells Against Oxidative Stress and Cellular Senescence.
Title: HO-1-Mediated Autophagic Restoration Protects Lens Epithelial Cells Against Oxidative Stress and Cellular Senescence.
Adoptive transfer of immature dendritic cells with high HO-1 expression delays the onset of T1DM in NOD mice.
Title: Adoptive transfer of immature dendritic cells with high HO-1 expression delays the onset of T1DM in NOD mice.
Expression of angiogenic factors in the placenta of heme oxygenase-1 deficient mouse embryo.
Title: Expression of angiogenic factors in the placenta of heme oxygenase-1 deficient mouse embryo.
Pregnane X receptor (PXR) deficiency protects against spinal cord injury by activating NRF2/HO-1 pathway.
Title: Pregnane X receptor (PXR) deficiency protects against spinal cord injury by activating NRF2/HO-1 pathway.
Heme oxygenase-1 increases intracellular iron storage and suppresses inflammatory response of macrophages by inhibiting M1 polarization.
Title: Heme oxygenase-1 increases intracellular iron storage and suppresses inflammatory response of macrophages by inhibiting M1 polarization.

Submit: New GeneRIF Correction See all GeneRIFs (655)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (11) 1 citation
Endonuclease-mediated (7)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

d19arb1 (e-PCR)
- UniSTS:121355

PMC341742P5 (e-PCR)
- UniSTS:273179

PMC341742P6 (e-PCR)
- UniSTS:273180

PMC341742P7 (e-PCR)
- UniSTS:273181

UniSTS:472912 (e-PCR)
- UniSTS:472912

Hmox1 (e-PCR), detects polymorphism
- UniSTS:472912

RH126510 (e-PCR)
- UniSTS:142732

PMC164851P2 (e-PCR)
- UniSTS:271522

PMC129038P1 (e-PCR)
- UniSTS:270578

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables arachidonic acid omega-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables heme oxygenase (decyclizing) activity	IBA Inferred from Biological aspect of Ancestor more info
enables heme oxygenase (decyclizing) activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables phospholipase D activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables structural molecule activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to arsenic-containing substance	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to cadmium ion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to cisplatin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to heat	ISO Inferred from Sequence Orthology more info
acts_upstream_of epithelial cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in erythrocyte homeostasis	ISO Inferred from Sequence Orthology more info
involved_in heme catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heme catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in heme catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heme metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in heme oxidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in heme oxidation	ISO Inferred from Sequence Orthology more info
involved_in intracellular iron ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	ISO Inferred from Sequence Orthology more info
involved_in liver regeneration	ISO Inferred from Sequence Orthology more info
acts_upstream_of macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organismal-level iron ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mast cell cytokine production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mast cell degranulation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of epithelial cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to arachidonic acid	ISO Inferred from Sequence Orthology more info
involved_in response to estrogen	ISO Inferred from Sequence Orthology more info
involved_in response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in response to nicotine	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in small GTPase-mediated signal transduction	ISO Inferred from Sequence Orthology more info
involved_in wound healing involved in inflammatory response	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in caveola	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IGI Inferred from Genetic Interaction more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: heme oxygenase 1

Names: P32 protein; heme oxygenase (decycling) 1; hemoxygenase

NP_034572.1

EC 1.14.14.18

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.