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    Hdgfl3 HDGF like 3 [ Mus musculus (house mouse) ]

    Gene ID: 29877, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Hdgfl3provided by MGI
    Official Full Name
    HDGF like 3provided by MGI
    Primary source
    MGI:MGI:1352760
    See related
    Ensembl:ENSMUSG00000025104 AllianceGenome:MGI:1352760
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HRP-3; Hdgfrp3; 2700022B06Rik
    Summary
    Enables microtubule binding activity. Involved in microtubule polymerization; negative regulation of microtubule depolymerization; and neuron projection development. Located in cytosol and nucleus. Is expressed in metanephros and nervous system. Orthologous to human HDGFL3 (HDGF like 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E18 (RPKM 20.4), whole brain E14.5 (RPKM 19.7) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 D3; 7 45.71 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (81531004..81587227, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (81881256..81934459, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene BTB domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_19371 Neighboring gene predicted gene, 32695 Neighboring gene predicted gene, 51491 Neighboring gene STARR-seq mESC enhancer starr_19372 Neighboring gene transmembrane 6 superfamily member 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:89025770-89025983 Neighboring gene STARR-seq mESC enhancer starr_19373 Neighboring gene STARR-seq mESC enhancer starr_19374 Neighboring gene STARR-seq mESC enhancer starr_19375 Neighboring gene basonuclin zinc finger protein 1 Neighboring gene STARR-seq mESC enhancer starr_19377 Neighboring gene predicted gene, 46013

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Hepatoma-derived growth factor-related protein-3: a new neurotrophic and neurite outgrowth-promoting factor for cortical neurons. Abouzied MM, et al. J Neurosci Res, 2010 Dec. PMID 20890995
    2. Solution structure of the PWWP domain of the hepatoma-derived growth factor family. Nameki N, et al. Protein Sci, 2005 Mar. PMID 15689505, Free PMC Article
    3. Motoneuron expression profiling identifies an association between an axonal splice variant of HDGF-related protein 3 and peripheral myelination. Kerman BE, et al. J Biol Chem, 2020 Aug 21. PMID 32647008, Free PMC Article
    4. Hepatoma-derived growth factor-related protein-3 interacts with microtubules and promotes neurite outgrowth in mouse cortical neurons. El-Tahir HM, et al. J Biol Chem, 2009 Apr 24. PMID 19237540, Free PMC Article
    5. A new member of a hepatoma-derived growth factor gene family can translocate to the nucleus. Ikegame K, et al. Biochem Biophys Res Commun, 1999 Dec 9. PMID 10581169

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Motoneuron expression profiling identifies an association between an axonal splice variant of HDGF-related protein 3 and peripheral myelination.
      Title: Motoneuron expression profiling identifies an association between an axonal splice variant of HDGF-related protein 3 and peripheral myelination.
    2. Antibody-mediated neutralization of HRP-3 function results in neuronal degeneration; this protein also exerts a neurite outgrowth-promoting effect when it is presented as a coated substrate but not as a soluble factor.
      Title: Hepatoma-derived growth factor-related protein-3: a new neurotrophic and neurite outgrowth-promoting factor for cortical neurons.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables tubulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule polymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of microtubule depolymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hepatoma-derived growth factor-related protein 3
    Names
    hepatoma-derived growth factor, related protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013886.4 → NP_038914.2  hepatoma-derived growth factor-related protein 3

      See identical proteins and their annotated locations for NP_038914.2

      Status: VALIDATED

      Source sequence(s)
      AK012267, AK045542, AK162418
      Consensus CDS
      CCDS40011.1
      UniProtKB/Swiss-Prot
      Q3TRX2, Q8BQ69, Q8BR62, Q9D2M7, Q9JMG7
      Related
      ENSMUSP00000102926.2, ENSMUST00000107305.8
      Conserved Domains (1) summary
      cd05834
      Location:7 → 91
      HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      81531004..81587227 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153161.1 → XP_036009054.1  hepatoma-derived growth factor-related protein 3 isoform X1

      UniProtKB/TrEMBL
      Q3TR90
      Conserved Domains (1) summary
      cd05834
      Location:7 → 91
      HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JMG7.2 GenPept UniProtKB/Swiss-Prot:Q9JMG7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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