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    JCHAIN joining chain of multimeric IgA and IgM [ Homo sapiens (human) ]

    Gene ID: 3512, updated on 3-Apr-2024

    Summary

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    Official Symbol
    JCHAINprovided by HGNC
    Official Full Name
    joining chain of multimeric IgA and IgMprovided by HGNC
    Primary source
    HGNC:HGNC:5713
    See related
    Ensembl:ENSG00000132465 MIM:147790; AllianceGenome:HGNC:5713
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IGJ; JCH; IGCJ
    Summary
    Enables IgA binding activity and protein homodimerization activity. Contributes to several functions, including immunoglobulin receptor binding activity; peptidoglycan binding activity; and phosphatidylcholine binding activity. Involved in several processes, including defense response to other organism; glomerular filtration; and positive regulation of respiratory burst. Located in extracellular space. Part of monomeric IgA immunoglobulin complex; pentameric IgM immunoglobulin complex; and secretory dimeric IgA immunoglobulin complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in colon (RPKM 2264.9), duodenum (RPKM 2014.1) and 10 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See JCHAIN in Genome Data Viewer
    Location:
    4q13.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (70655541..70666508, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (73998009..74019368, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (71521258..71532225, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr4:71464845-71465050 Neighboring gene ameloblastin Neighboring gene enamelin Neighboring gene uncharacterized LOC101927297 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:71553174-71554144 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:71554145-71555113 Neighboring gene UTP3 small subunit processome component

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Expression and glycoengineering of functionally active heteromultimeric IgM in plants. Loos A, et al. Proc Natl Acad Sci U S A, 2014 Apr 29. PMID 24706782, Free PMC Article
    2. Mutagenesis of the human IgA1 heavy chain tailpiece that prevents dimer assembly. Atkin JD, et al. J Immunol, 1996 Jul 1. PMID 8683109
    3. The J chain gene is transcribed during B and T lymphopoiesis in humans. Bertrand FE 3rd, et al. J Immunol, 1996 Jun 1. PMID 8666793
    4. Glandular distribution of immunoglobulins, J chain, secretory component, and HLA-DR in the human endometrium throughout the menstrual cycle. Bjercke S, et al. Hum Reprod, 1993 Sep. PMID 8253928
    5. Expression of J chain mRNA in duodenal IgA plasma cells in IgA nephropathy. Harper SJ, et al. Kidney Int, 1994 Mar. PMID 8196286

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IGJ suppresses breast cancer growth and metastasis by inhibiting EMT via the NF-kappaB signaling pathway.
      Title: IGJ suppresses breast cancer growth and metastasis by inhibiting EMT via the NF‑κB signaling pathway.
    2. Results show that ID1, ID3 and IGJ genes are highly expressed in adult B-ALL and correlate with poor prognosis in Hispanic patients.
      Title: High expression of ID family and IGJ genes signature as predictor of low induction treatment response and worst survival in adult Hispanic patients with B-acute lymphoblastic leukemia.
    3. TLR2 ligands induce CCR9 and CCR10 expression by circulating B-cells and increase their chemotaxis. TLR2 stimulation also induced J chain and IgA production demonstrating the induction of mucosal-like antibody secreting cells.
      Title: Toll-like receptor 2 induces mucosal homing receptor expression and IgA production by human B cells.
    4. Observational study of gene-disease association. (HuGE Navigator)
      Title: New genetic associations detected in a host response study to hepatitis B vaccine.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables IgA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables antigen binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    contributes_to immunoglobulin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to immunoglobulin receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to immunoglobulin receptor binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    contributes_to peptidoglycan binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to phosphatidylcholine binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adaptive immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in antibacterial humoral response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glomerular filtration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in humoral immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in innate immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of respiratory burst IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein-containing complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in blood microparticle HDA PubMed 
    part_of dimeric IgA immunoglobulin complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular space HDA PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT part_of hexameric IgM immunoglobulin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of monomeric IgA immunoglobulin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of pentameric IgM immunoglobulin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of pentameric IgM immunoglobulin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of secretory IgA immunoglobulin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of secretory dimeric IgA immunoglobulin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    immunoglobulin J chain
    Names
    IgJ chain
    J chain
    immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144646.4 → NP_653247.1  immunoglobulin J chain precursor

      See identical proteins and their annotated locations for NP_653247.1

      Status: VALIDATED

      Source sequence(s)
      BC038982, BP221304, BP418109
      Consensus CDS
      CCDS3545.1
      UniProtKB/Swiss-Prot
      P01591
      UniProtKB/TrEMBL
      D6RD17
      Related
      ENSP00000254801.4, ENST00000254801.9
      Conserved Domains (1) summary
      pfam15097
      Location:24 → 159
      Ig_J_chain; Immunoglobulin J chain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      70655541..70666508 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      73998009..74019368 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054349954.1 → XP_054205929.1  immunoglobulin J chain isoform X2

      UniProtKB/Swiss-Prot
      P01591

    2. XM_054349955.1 → XP_054205930.1  immunoglobulin J chain isoform X2

      UniProtKB/Swiss-Prot
      P01591

    3. XM_054349953.1 → XP_054205928.1  immunoglobulin J chain isoform X2

      UniProtKB/Swiss-Prot
      P01591

    4. XM_054349952.1 → XP_054205927.1  immunoglobulin J chain isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P01591.4 GenPept UniProtKB/Swiss-Prot:P01591

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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