Wdr45b WD repeat domain 45B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wdr45bprovided by MGI
Official Full Name: WD repeat domain 45Bprovided by MGI
Primary source: MGI:MGI:1914090
See related: Ensembl:ENSMUSG00000025173 AllianceGenome:MGI:1914090
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: WIPI-3; Wdr45l; D16Bwg0193e; 0610008N23Rik
Summary: Predicted to enable TSC1-TSC2 complex binding activity; phosphatidylinositol-3,5-bisphosphate binding activity; and phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in several processes, including autophagy of mitochondrion; autophagy of nucleus; and protein localization to phagophore assembly site. Predicted to act upstream of or within autophagy. Predicted to be located in lysosome and phagophore assembly site. Predicted to be active in cytosol and phagophore assembly site membrane. Predicted to be extrinsic component of membrane. Orthologous to human WDR45B (WD repeat domain 45B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in limb E14.5 (RPKM 23.7), ovary adult (RPKM 19.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 85.24 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (121218029..121246393, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (121327203..121354447, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Wipi3 is essential for alternative autophagy and its loss causes neurodegeneration.
Title: Wipi3 is essential for alternative autophagy and its loss causes neurodegeneration.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124753 (e-PCR)
- UniSTS:161575

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

D11Ertd712e (e-PCR), detects polymorphism
- UniSTS:167072

D16Bwg0193e (e-PCR), detects polymorphism
- UniSTS:142035

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables TSC1-TSC2 complex binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,5-bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3-phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3-phosphate binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in autophagosome assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within autophagy	IEA Inferred from Electronic Annotation more info
involved_in autophagy of mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagy of peroxisome	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to starvation	ISO Inferred from Sequence Orthology more info
involved_in glycophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein lipidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to phagophore assembly site	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extrinsic component of membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in phagophore assembly site	ISO Inferred from Sequence Orthology more info
is_active_in phagophore assembly site membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: WD repeat domain phosphoinositide-interacting protein 3

Names: WD repeat-containing protein 45-like; WD repeat-containing protein 45B; WDR45-like protein; Wdr45 like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025793.3 → NP_080069.2 WD repeat domain phosphoinositide-interacting protein 3

See identical proteins and their annotated locations for NP_080069.2

Status: VALIDATED

Source sequence(s)

AK146101, BY618193

Consensus CDS

CCDS25773.1

UniProtKB/Swiss-Prot

Q3U924, Q9CR39

Related

ENSMUSP00000026173.7, ENSMUST00000026173.13

Conserved Domains (2) summary

sd00039
Location:145 → 183

7WD40; WD40 repeat [structural motif]

cl29593
Location:25 → 258

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...