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    Nkd1 naked cuticle 1 [ Mus musculus (house mouse) ]

    Gene ID: 93960, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Nkd1provided by MGI
    Official Full Name
    naked cuticle 1provided by MGI
    Primary source
    MGI:MGI:2135954
    See related
    Ensembl:ENSMUSG00000031661 AllianceGenome:MGI:2135954
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nkd; 2810434J10Rik; 9030215G15Rik
    Summary
    Enables PDZ domain binding activity. Involved in negative regulation of convergent extension involved in axis elongation and regulation of Wnt signaling pathway. Predicted to be located in plasma membrane. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytoplasm. Is expressed in several structures, including brain; genitourinary system; gut; retina; and unsegmented mesenchyme. Orthologous to human NKD1 (NKD inhibitor of WNT signaling pathway 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in lung adult (RPKM 30.7), bladder adult (RPKM 15.6) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 C3; 8 43.36 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (89247961..89321515)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (88521342..88594887)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35076 Neighboring gene predicted gene, 35162 Neighboring gene STARR-positive B cell enhancer ABC_E10516 Neighboring gene STARR-seq mESC enhancer starr_22236 Neighboring gene STARR-seq mESC enhancer starr_22237 Neighboring gene sorting nexin 20 Neighboring gene STARR-positive B cell enhancer ABC_E2869 Neighboring gene STARR-positive B cell enhancer ABC_E3791 Neighboring gene nucleotide-binding oligomerization domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E6672

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Viable mice with compound mutations in the Wnt/Dvl pathway antagonists nkd1 and nkd2. Zhang S, et al. Mol Cell Biol, 2007 Jun. PMID 17438140, Free PMC Article
    2. The NKD1/Rac1 feedback loop regulates the invasion and migration ability of hepatocarcinoma cells. Li J, et al. Sci Rep, 2016 May 27. PMID 27231134, Free PMC Article
    3. Gene expression profiles of brain endothelial cells during embryonic development at bulk and single-cell levels. Hupe M, et al. Sci Signal, 2017 Jul 11. PMID 28698213
    4. Fluid flow and interlinked feedback loops establish left-right asymmetric decay of Cerl2 mRNA. Nakamura T, et al. Nat Commun, 2012. PMID 23271656
    5. Dose-dependent regulation of oligodendrocyte specification by β-catenin signaling. Sun S, et al. Neurosci Bull, 2015 Apr. PMID 25754147, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Naked cuticle homolog 1 prevents mouse pulmonary arterial hypertension via inhibition of Wnt/beta-catenin and oxidative stress.
      Title: Naked cuticle homolog 1 prevents mouse pulmonary arterial hypertension via inhibition of Wnt/β-catenin and oxidative stress.
    2. The NKD1/Rac1 feedback loop regulates the invasion and migration ability of hepatocellular carcinoma cells.
      Title: The NKD1/Rac1 feedback loop regulates the invasion and migration ability of hepatocarcinoma cells.
    3. Viable mice were obtained with compound mutations in the Wnt/Dvl pathway antagonists nkd1 and nkd2.
      Title: Viable mice with compound mutations in the Wnt/Dvl pathway antagonists nkd1 and nkd2.
    4. deletion of the EF-hand from Nkd1 reduces the number of the elongating spermatids at haploid stage
      Title: A targeted mutation of Nkd1 impairs mouse spermatogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables PDZ domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in axis elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in convergent extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of Wnt signaling pathway, planar cell polarity pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of non-canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein phosphatase type 2A complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein naked cuticle homolog 1
    Names
    mNkd
    mNkd1
    naked cuticle 1 homolog
    naked-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163660.1 → NP_001157132.1  protein naked cuticle homolog 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC126054, DV662736
      Consensus CDS
      CCDS52631.1
      UniProtKB/TrEMBL
      E9Q5K6
      Related
      ENSMUSP00000125935.2, ENSMUST00000169179.3
      Conserved Domains (1) summary
      pfam13499
      Location:33 → 66
      EF-hand_7; EF-hand domain pair

    2. NM_027280.3 → NP_081556.3  protein naked cuticle homolog 1 isoform 1

      See identical proteins and their annotated locations for NP_081556.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC126054, AK166564, BC034838
      Consensus CDS
      CCDS22511.1
      UniProtKB/Swiss-Prot
      Q3TLD6, Q8K200, Q91Y46, Q99MH6
      Related
      ENSMUSP00000034086.6, ENSMUST00000034086.13

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      89247961..89321515
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243873.2 → XP_030099733.1  protein naked cuticle homolog 1 isoform X1

      UniProtKB/TrEMBL
      E9Q5K6
      Related
      ENSMUSP00000147347.2, ENSMUST00000211113.2
      Conserved Domains (1) summary
      pfam13499
      Location:33 → 66
      EF-hand_7; EF-hand domain pair
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99MH6.1 GenPept UniProtKB/Swiss-Prot:Q99MH6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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