Mybl2 myeloblastosis oncogene-like 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mybl2provided by MGI
Official Full Name: myeloblastosis oncogene-like 2provided by MGI
Primary source: MGI:MGI:101785
See related: Ensembl:ENSMUSG00000017861 AllianceGenome:MGI:101785
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bmyb; B-Myb
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor and mitotic spindle assembly. Located in nucleus. Part of Myb complex. Is expressed in several structures, including brain; early conceptus; genitourinary system; hemolymphoid system; and skin. Used to study acute myeloid leukemia and myelodysplastic syndrome. Orthologous to human MYBL2 (MYB proto-oncogene like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in liver E14.5 (RPKM 17.0), liver E14 (RPKM 15.7) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H2; 2 84.0 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (162896246..162926608)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (163054327..163084688)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Notch3 regulates Mybl2 via HeyL to limit proliferation and tumor initiation in breast cancer.
Title: Notch3 regulates Mybl2 via HeyL to limit proliferation and tumor initiation in breast cancer.
Protein-protein interaction studies showed that YAP binds directly to B-MYB, a subunit of MMB, in a manner dependent on the YAP WW domains and a PPXY motif in B-MYB. Disruption of the interaction by overexpression of the YAP binding domain of B-MYB strongly inhibits the proliferation of cardiomyocytes.
Title: Interaction of YAP with the Myb-MuvB (MMB) complex defines a transcriptional program to promote the proliferation of cardiomyocytes.
Downregulation of B-myb induced senescence by upregulation of p22(phox) and activation of the ROS/p53/p21 pathway
Title: Downregulation of B-myb promotes senescence via the ROS-mediated p53/p21 pathway, in vascular endothelial cells.
B-myb is an essential regulator of hematopoietic stem cell and myeloid progenitor cell development.
Title: B-myb is an essential regulator of hematopoietic stem cell and myeloid progenitor cell development.
MYBL2 haploinsufficiency increases susceptibility to age-related haematopoietic neoplasia.
Title: MYBL2 haploinsufficiency increases susceptibility to age-related haematopoietic neoplasia.
Results coupled with functional studies demonstrate that B-MYB not only controls and accelerates cell cycle progression in ESCs it contributes to fate decisions and maintenance of pluripotent stem cell identity.
Title: The B-MYB transcriptional network guides cell cycle progression and fate decisions to sustain self-renewal and the identity of pluripotent stem cells.
Our data suggest that B-Myb is required as a pioneer factor to enable FoxM1 binding to G2/M gene promoters and explains how these transcription factors may collaborate to induce mitosis.
Title: Binding of FoxM1 to G2/M gene promoters is dependent upon B-Myb.
Mybl2 upregulation induces fast growth and progression of premalignant and malignant liver, through cell cycle deregulation and activation of genes and pathways related to tumor progression.
Title: Mybl2 expression is under genetic control and contributes to determine a hepatocellular carcinoma susceptible phenotype.
Lin-9 and B-Myb were both required for transcription of G(2)/M genes such as Cyclin B1 and Survivin.
Title: A Lin-9 complex is recruited by B-Myb to activate transcription of G2/M genes in undifferentiated embryonal carcinoma cells.
proliferation-inhibiting A(2B)AR is itself an inducible receptor regulated by B-Myb.
Title: B-Myb regulates the A(2B) adenosine receptor in vascular smooth muscle cells.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (8) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Mybl2 (e-PCR), detects polymorphism
- UniSTS:143941

NoName (e-PCR)
- UniSTS:234592

PMC86057P3 (e-PCR)
- UniSTS:273515

MT2636 (e-PCR)
- UniSTS:129177

D2Mit290.4 (e-PCR), detects polymorphism
- UniSTS:129178

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitotic spindle assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Myb complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: myb-related protein B

Names: myb-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008652.2 → NP_032678.1 myb-related protein B

See identical proteins and their annotated locations for NP_032678.1

Status: PROVISIONAL

Source sequence(s)

AK028497

Consensus CDS

CCDS17006.1

UniProtKB/Swiss-Prot

P48972

Related

ENSMUSP00000018005.4, ENSMUST00000018005.10

Conserved Domains (4) summary

smart00717
Location:83 → 131

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam00249
Location:83 → 129

Myb_DNA-binding; Myb-like DNA-binding domain

pfam09316
Location:454 → 599

Cmyb_C; C-myb, C-terminal

pfam13921
Location:34 → 94

Myb_DNA-bind_6; Myb-like DNA-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

162896246..162926608

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006498875.5 → XP_006498938.1 myb-related protein B isoform X2

Conserved Domains (3) summary

PLN03091
Location:81 → 219

PLN03091; hypothetical protein; Provisional

pfam09316
Location:317 → 497

Cmyb_C; C-myb, C-terminal

pfam13921
Location:34 → 94

Myb_DNA-bind_6; Myb-like DNA-binding domain
XM_006498876.5 → XP_006498939.1 myb-related protein B isoform X3

See identical proteins and their annotated locations for XP_006498939.1

Conserved Domains (2) summary

PLN03091
Location:2 → 57

PLN03091; hypothetical protein; Provisional

pfam09316
Location:292 → 476

Cmyb_C; C-myb, C-terminal
XM_006498873.5 → XP_006498936.1 myb-related protein B isoform X1

Conserved Domains (3) summary

PLN03091
Location:81 → 219

PLN03091; hypothetical protein; Provisional

pfam09316
Location:454 → 638

Cmyb_C; C-myb, C-terminal

pfam13921
Location:34 → 94

Myb_DNA-bind_6; Myb-like DNA-binding domain
XM_006498878.5 → XP_006498941.1 myb-related protein B isoform X4

Conserved Domains (3) summary

PLN03091
Location:81 → 219

PLN03091; hypothetical protein; Provisional

pfam09316
Location:317 → 458

Cmyb_C; C-myb, C-terminal

pfam13921
Location:34 → 94

Myb_DNA-bind_6; Myb-like DNA-binding domain