Apof apolipoprotein F [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Apofprovided by MGI
Official Full Name: apolipoprotein Fprovided by MGI
Primary source: MGI:MGI:104539
See related: Ensembl:ENSMUSG00000047631 AllianceGenome:MGI:104539
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Acts upstream of or within cholesterol efflux; cholesterol metabolic process; and triglyceride metabolic process. Predicted to be located in extracellular region. Predicted to be part of high-density lipoprotein particle and low-density lipoprotein particle. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; hemolymphoid system gland; liver; and reproductive system. Orthologous to human APOF (apolipoprotein F). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 507.2) and liver E18 (RPKM 297.1) See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 10 D3; 10 76.5 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (128104568..128107119)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (128268699..128271250)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Unveiling the Impact of ApoF Deficiency on Liver and Lipid Metabolism: Insights from Transcriptome-Wide m6A Methylome Analysis in Mice.
Title: Unveiling the Impact of ApoF Deficiency on Liver and Lipid Metabolism: Insights from Transcriptome-Wide m6A Methylome Analysis in Mice.
this study has identified apoF as likely another target gene of FXR.
Title: Farnesoid X receptor up-regulates expression of lipid transfer inhibitor protein in liver cells and mice.
Deletion of ApoF had no substantial impact on plasma lipid concentrations, high density lipoprotein cholesterol size, lipid or protein composition.
Title: The effects of apolipoprotein F deficiency on high density lipoprotein cholesterol metabolism in mice.
Overexpression of murine ApoF significantly reduced total cholesterol levels by 28%, high density lipoproteins by 27% and phospholipid levels by 19%.
Title: Overexpression of apolipoprotein F reduces HDL cholesterol levels in vivo.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (1)

General gene information

Go to the top of the page Help

Markers

AI255964 (e-PCR)
- UniSTS:180127

PMC153798P1 (e-PCR)
- UniSTS:271273

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cholesterol efflux	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cholesterol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cholesterol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within steroid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within triglyceride metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of high-density lipoprotein particle	IEA Inferred from Electronic Annotation more info
part_of low-density lipoprotein particle	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: apolipoprotein F

Names: LVIF; apo-F; leukemia virus-inactivating factor

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133997.3 → NP_598758.2 apolipoprotein F precursor

Status: VALIDATED

Source sequence(s)

AC135859

Consensus CDS

CCDS24268.2

UniProtKB/Swiss-Prot

Q91V80

UniProtKB/TrEMBL

A0A0R4J0M4

Related

ENSMUSP00000050300.4, ENSMUST00000050901.5

Conserved Domains (1) summary

pfam15148
Location:53 → 250

Apolipo_F; Apolipoprotein F