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    Pfdn2 prefoldin 2 [ Mus musculus (house mouse) ]

    Gene ID: 18637, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Pfdn2provided by MGI
    Official Full Name
    prefoldin 2provided by MGI
    Primary source
    MGI:MGI:1276111
    See related
    Ensembl:ENSMUSG00000006412 AllianceGenome:MGI:1276111
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ESTM27
    Summary
    Predicted to enable amyloid-beta binding activity; protein folding chaperone; and unfolded protein binding activity. Acts upstream of or within protein folding. Predicted to be located in cytosol; mitochondrion; and nucleus. Predicted to be part of prefoldin complex. Predicted to be active in cytoplasm. Orthologous to human PFDN2 (prefoldin subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 48.2), CNS E14 (RPKM 27.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 H3; 1 79.35 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (171172522..171186822)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (171344954..171359254)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 25151 Neighboring gene predicted gene, 20045 Neighboring gene death effector domain-containing Neighboring gene STARR-positive B cell enhancer ABC_E2019 Neighboring gene nitrilase 1 Neighboring gene STARR-positive B cell enhancer ABC_E4387 Neighboring gene kelch domain containing 9 Neighboring gene nectin cell adhesion molecule 4 Neighboring gene STARR-positive B cell enhancer ABC_E4388 Neighboring gene Rho GTPase activating protein 30 Neighboring gene STARR-positive B cell enhancer ABC_E4389

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Multipronged approach to identify and validate a novel upstream regulator of Sncg in mouse retinal ganglion cells. Chintalapudi SR, et al. FEBS J, 2016 Feb. PMID 26663874
    2. Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin. Vainberg IE, et al. Cell, 1998 May 29. PMID 9630229
    3. Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp). Eddleston J, et al. Genomics, 1999 Mar 1. PMID 10051400
    4. ALS-linked loss of Cyclin-F function affects HSP90. Siebert A, et al. Life Sci Alliance, 2022 Sep 16. PMID 36114006, Free PMC Article
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Transgenic (1) 
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables amyloid-beta binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein folding chaperone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein folding chaperone ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables unfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of amyloid fibril formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein folding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein folding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of RPAP3/R2TP/prefoldin-like complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of prefoldin complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    prefoldin subunit 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360824.1 → NP_001347753.1  prefoldin subunit 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC087229
      UniProtKB/TrEMBL
      F8WJ30
      Related
      ENSMUSP00000006579.5, ENSMUST00000006579.5
      Conserved Domains (1) summary
      pfam01920
      Location:24 → 96
      Prefoldin_2; Prefoldin subunit

    2. NM_001360825.1 → NP_001347754.1  prefoldin subunit 2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC087229
      Conserved Domains (1) summary
      pfam01920
      Location:1 → 79
      Prefoldin_2; Prefoldin subunit

    3. NM_011070.4 → NP_035200.2  prefoldin subunit 2 isoform 1

      See identical proteins and their annotated locations for NP_035200.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC087229
      Consensus CDS
      CCDS15491.1
      UniProtKB/Swiss-Prot
      O70591, Q8R0H2
      Related
      ENSMUSP00000120106.2, ENSMUST00000135941.8
      Conserved Domains (1) summary
      pfam01920
      Location:24 → 127
      Prefoldin_2; Prefoldin subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      171172522..171186822
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O70591.2 GenPept UniProtKB/Swiss-Prot:O70591

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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