Cd99l2 CD99 antigen-like 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd99l2provided by MGI
Official Full Name: CD99 antigen-like 2provided by MGI
Primary source: MGI:MGI:2177151
See related: Ensembl:ENSMUSG00000035776 AllianceGenome:MGI:2177151
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Xap89; Mic2l1
Summary: Acts upstream of or within diapedesis; homotypic cell-cell adhesion; and positive regulation of cellular extravasation. Located in adherens junction and cell surface. Is expressed in several structures, including alimentary system; hemolymphoid system; nervous system; reproductive system; and skin. Orthologous to human CD99L2 (CD99 molecule like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E18 (RPKM 23.1), whole brain E14.5 (RPKM 17.7) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A7.3; X 36.82 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (70463666..70536467, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (71420060..71492866, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Conditional Tie-2-Cre driven gene inactivation of CD99L2 inhibits leukocyte entry into the CNS during active MOG35-55 -induced experimental autoimmune encephalomyelitis and alleviates severity of the disease. CD99L2 participates in the development of EAE by supporting diapedesis of leukocytes through the endothelial basement membrane of blood vessels of the BBB in the CNS.
Title: CD99L2 deficiency inhibits leukocyte entry into the central nervous system and ameliorates neuroinflammation.
Mice lacking CD99L2 had a defective inflammatory response in the thioglycollate peritonitis model
Title: CD99-like 2 (CD99L2)-deficient mice are defective in the acute inflammatory response.
The present study provides data for further investigation into the mCD99L2 gene in tumor cells.
Title: Effect of shRNA targeting mouse CD99L2 gene in a murine B cell lymphoma in vitro and in vivo.
CD99L2 is an essential endothelial Ag for leukocyte extravasation, which does not require homophilic interactions with CD99L2 on leukocytes.
Title: Cutting edge: Endothelial-specific gene ablation of CD99L2 impairs leukocyte extravasation in vivo.
Transfection of L cell fibroblasts with CD99L2 imparted to them the ability to adhere to each other in a divalent cation-dependent, homophilic manner. Anti-CD99L2 antibody blocked influx of neutrophils and monocytes into a site of inflammation in vivo.
Title: The murine CD99-related molecule CD99-like 2 (CD99L2) is an adhesion molecule involved in the inflammatory response.
expressed on mouse leukocytes and endothelial cells and is involved in transendothelial migration of neutrophils in vitro and in the recruitment of neutrophils into inflamed peritoneum
Title: A CD99-related antigen on endothelial cells mediates neutrophil but not lymphocyte extravasation in vivo.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW049210 (e-PCR)
- UniSTS:181293

AW548191 (e-PCR)
- UniSTS:181294

Cd99l2 (e-PCR), detects polymorphism
- UniSTS:516719

Cd99l2 (e-PCR), detects polymorphism
- UniSTS:516720

px-7b5 (e-PCR)
- UniSTS:258187

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within diapedesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of T cell extravasation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of neutrophil extravasation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: CD99 antigen-like protein 2

Names: MIC2 (monoclonal Imperial Cancer Research Fund 2)-like 1; MIC2 like-1; MIC2-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001199349.1 → NP_001186278.1 CD99 antigen-like protein 2 isoform 1 precursor

See identical proteins and their annotated locations for NP_001186278.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).

Source sequence(s)

AK080225, BF147574, BY727540

Consensus CDS

CCDS57761.1

UniProtKB/Swiss-Prot

A2AP77, Q8BIF0, Q8R447

UniProtKB/TrEMBL

A2AP74

Related

ENSMUSP00000042606.6, ENSMUST00000037391.12

Conserved Domains (1) summary

pfam12301
Location:30 → 215

CD99L2; CD99 antigen like protein 2
NM_138309.3 → NP_612182.1 CD99 antigen-like protein 2 isoform 2 precursor

See identical proteins and their annotated locations for NP_612182.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate, in-frame, exon in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.

Source sequence(s)

AK080225, AY078163, BF147574, BY727540

Consensus CDS

CCDS30179.1

UniProtKB/TrEMBL

I7HJQ8

Related

ENSMUSP00000078944.5, ENSMUST00000080035.11

Conserved Domains (1) summary

pfam12301
Location:30 → 192

CD99L2; CD99 antigen like protein 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

70463666..70536467 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006527887.5 → XP_006527950.1 CD99 antigen-like protein 2 isoform X2

UniProtKB/TrEMBL

I7HJQ8

Conserved Domains (1) summary

pfam12301
Location:30 → 198

CD99L2; CD99 antigen like protein 2
XM_006527886.5 → XP_006527949.1 CD99 antigen-like protein 2 isoform X1

UniProtKB/TrEMBL

A2AP74

Conserved Domains (1) summary

pfam12301
Location:30 → 221

CD99L2; CD99 antigen like protein 2
XM_011247540.3 → XP_011245842.1 CD99 antigen-like protein 2 isoform X3

See identical proteins and their annotated locations for XP_011245842.1

Conserved Domains (2) summary

pfam12301
Location:65 → 144

CD99L2; CD99 antigen like protein 2

cl19816
Location:24 → 71

Hydantoinase_B; Hydantoinase B/oxoprolinase
XM_017318407.3 → XP_017173896.1 CD99 antigen-like protein 2 isoform X4

Conserved Domains (2) summary

pfam12301
Location:65 → 138

CD99L2; CD99 antigen like protein 2

cl19816
Location:24 → 71

Hydantoinase_B; Hydantoinase B/oxoprolinase
XM_011247541.3 → XP_011245843.1 CD99 antigen-like protein 2 isoform X3

See identical proteins and their annotated locations for XP_011245843.1

Conserved Domains (2) summary

pfam12301
Location:65 → 144

CD99L2; CD99 antigen like protein 2

cl19816
Location:24 → 71

Hydantoinase_B; Hydantoinase B/oxoprolinase
XM_011247542.4 → XP_011245844.1 CD99 antigen-like protein 2 isoform X3

See identical proteins and their annotated locations for XP_011245844.1

Conserved Domains (2) summary

pfam12301
Location:65 → 144

CD99L2; CD99 antigen like protein 2

cl19816
Location:24 → 71

Hydantoinase_B; Hydantoinase B/oxoprolinase