Bnc1 basonuclin zinc finger protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bnc1provided by MGI
Official Full Name: basonuclin zinc finger protein 1provided by MGI
Primary source: MGI:MGI:1097164
See related: Ensembl:ENSMUSG00000025105 AllianceGenome:MGI:1097164
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bnc
Summary: Predicted to enable DNA-binding transcription activator activity and rDNA binding activity. Acts upstream of or within several processes, including positive regulation of epithelial cell proliferation; regulation of transcription, DNA-templated; and wound healing. Located in cytoplasm and nucleolus. Is expressed in several structures, including alimentary system; branchial arch; gonad; outer layer of bladder; and skin. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 16. Orthologous to human BNC1 (basonuclin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in ovary adult (RPKM 1.4), placenta adult (RPKM 1.2) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 D3; 7 45.71 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (81616401..81642047, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (81966657..81992299, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BNC1 deficiency induces mitochondrial dysfunction-triggered spermatogonia apoptosis through the CREB/SIRT1/FOXO3 pathway: the therapeutic potential of nicotinamide riboside and metformindagger.
Title: BNC1 deficiency induces mitochondrial dysfunction-triggered spermatogonia apoptosis through the CREB/SIRT1/FOXO3 pathway: the therapeutic potential of nicotinamide riboside and metformin†.
BNC1 deficiency-triggered ferroptosis through the NF2-YAP pathway induces primary ovarian insufficiency.
Title: BNC1 deficiency-triggered ferroptosis through the NF2-YAP pathway induces primary ovarian insufficiency.
BNC1 Promotes Spermatogenesis by Regulating Transcription of Ybx2 and Papolb via Direct Binding to Their Promotor Elements.
Title: BNC1 Promotes Spermatogenesis by Regulating Transcription of Ybx2 and Papolb via Direct Binding to Their Promotor Elements.
Basonuclin 1 deficiency causes testicular premature aging: BNC1 cooperates with TAF7L to regulate spermatogenesis.
Title: Basonuclin 1 deficiency causes testicular premature aging: BNC1 cooperates with TAF7L to regulate spermatogenesis.
A female mouse model of the human Bnc1 frameshift mutation exhibited infertility, significantly increased serum follicle-stimulating hormone, decreased ovary size and reduced follicle numbers, consistent with primary ovarian insufficiency.
Title: Basonuclin 1 deficiency is a cause of primary ovarian insufficiency.
BNC1 cannot substitute for BNC2.
Title: The importance of basonuclin 2 in adult mice and its relation to basonuclin 1.
HSF2BP may play a pivotal role in regulating BNC1 transcriptional activity and subcellular localization during spermatogenesis.
Title: HSF2BP represses BNC1 transcriptional activity by sequestering BNC1 to the cytoplasm.
BNC1 is required for the maintenance of spermatogenesis.
Title: BNC1 is required for maintaining mouse spermatogenesis.
Basonuclin likely coordinates functions of a subset of ribosomal RNA genes (rDNA) and a group of protein coding genes in cellular processes critical for the regulation of cell proliferation
Title: Basonuclin-null mutation impairs homeostasis and wound repair in mouse corneal epithelium.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW546376 (e-PCR)
- UniSTS:179600

U88064 (e-PCR)
- UniSTS:159658

RH135843 (e-PCR)
- UniSTS:209841

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables rDNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of oocyte maturation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase I	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase I	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase I	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within wound healing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc finger protein basonuclin-1

Names: basonuclin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007562.2 → NP_031588.2 zinc finger protein basonuclin-1

See identical proteins and their annotated locations for NP_031588.2

Status: VALIDATED

Source sequence(s)

AC161216, AK051041, AK087567, BY146829

Consensus CDS

CCDS52285.1

UniProtKB/Swiss-Prot

O35914, O54886

UniProtKB/TrEMBL

F8VPY0

Related

ENSMUSP00000026096.8, ENSMUST00000026096.10

Conserved Domains (1) summary

sd00017
Location:356 → 377

ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

81616401..81642047 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011250781.4 → XP_011249083.1 zinc finger protein basonuclin-1 isoform X1

UniProtKB/Swiss-Prot

O35914, O54886

Conserved Domains (2) summary

sd00017
Location:354 → 375

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00019
Location:924 → 945

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_011250782.3 → XP_011249084.1 zinc finger protein basonuclin-1 isoform X2

UniProtKB/Swiss-Prot

O35914, O54886

Conserved Domains (2) summary

sd00017
Location:350 → 371

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam16014
Location:432 → 574

SAP130_C; Histone deacetylase complex subunit SAP130 C-terminus