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    Rarres2 retinoic acid receptor responder (tazarotene induced) 2 [ Mus musculus (house mouse) ]

    Gene ID: 71660, updated on 2-May-2024

    Summary

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    Official Symbol
    Rarres2provided by MGI
    Official Full Name
    retinoic acid receptor responder (tazarotene induced) 2provided by MGI
    Primary source
    MGI:MGI:1918910
    See related
    Ensembl:ENSMUSG00000009281 AllianceGenome:MGI:1918910
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0610007L05Rik
    Summary
    Predicted to enable signaling receptor binding activity. Involved in several processes, including positive regulation of fat cell differentiation; positive regulation of protein phosphorylation; and regulation of insulin receptor signaling pathway. Acts upstream of or within brown fat cell differentiation. Located in extracellular region. Is expressed in genitourinary system and retina. Orthologous to human RARRES2 (retinoic acid receptor responder 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver adult (RPKM 313.8), placenta adult (RPKM 166.0) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 B2.3; 6 23.55 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (48546630..48549778, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (48569696..48572845, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700026J14 gene Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit E2 Neighboring gene STARR-positive B cell enhancer ABC_E9271 Neighboring gene leucine rich repeat containing 61 Neighboring gene predicted gene 5111 Neighboring gene replication initiator 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Chemerin Exacerbates Psoriasis by Stimulating Keratinocyte Proliferation and Cytokine Production. Kong SM, et al. Curr Med Sci, 2023 Apr. PMID 37017855
    2. Adipokine chemerin overexpression in trophoblasts leads to dyslipidemia in pregnant mice: implications for preeclampsia. Tan L, et al. Lipids Health Dis, 2023 Jan 25. PMID 36698175, Free PMC Article
    3. Loss of chemerin triggers bone remodeling in vivo and in vitro. Han L, et al. Mol Metab, 2021 Nov. PMID 34416393, Free PMC Article
    4. Chemerin located in bone marrow promotes osteogenic differentiation and bone formation via Akt/Gsk3β/β-catenin axis in mice. Li J, et al. J Cell Physiol, 2021 Aug. PMID 33492671
    5. Chemerin Suppresses Breast Cancer Growth by Recruiting Immune Effector Cells Into the Tumor Microenvironment. Pachynski RK, et al. Front Immunol, 2019. PMID 31139180, Free PMC Article

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Chemerin triggers migration of a CD8 T cell subset with natural killer cell functions.
      Title: Chemerin triggers migration of a CD8 T cell subset with natural killer cell functions.
    2. Deletion of adipocyte NOS3 potentiates high-fat diet-induced hypertension and vascular remodelling via chemerin.
      Title: Deletion of adipocyte NOS3 potentiates high-fat diet-induced hypertension and vascular remodelling via chemerin.
    3. Aerobic exercise-induced decrease of chemerin improved glucose and lipid metabolism and fatty liver of diabetes mice through key metabolism enzymes and proteins.
      Title: Aerobic exercise-induced decrease of chemerin improved glucose and lipid metabolism and fatty liver of diabetes mice through key metabolism enzymes and proteins.
    4. Endothelial CCRL2 induced by disturbed flow promotes atherosclerosis via chemerin-dependent beta2 integrin activation in monocytes.
      Title: Endothelial CCRL2 induced by disturbed flow promotes atherosclerosis via chemerin-dependent β2 integrin activation in monocytes.
    5. RARRES2 regulates lipid metabolic reprogramming to mediate the development of brain metastasis in triple negative breast cancer.
      Title: RARRES2 regulates lipid metabolic reprogramming to mediate the development of brain metastasis in triple negative breast cancer.
    6. Chemerin Exacerbates Psoriasis by Stimulating Keratinocyte Proliferation and Cytokine Production.
      Title: Chemerin Exacerbates Psoriasis by Stimulating Keratinocyte Proliferation and Cytokine Production.
    7. The chemerin/CMKLR1 axis regulates intestinal graft-versus-host disease.
      Title: The chemerin/CMKLR1 axis regulates intestinal graft-versus-host disease.
    8. Adipokine chemerin overexpression in trophoblasts leads to dyslipidemia in pregnant mice: implications for preeclampsia.
      Title: Adipokine chemerin overexpression in trophoblasts leads to dyslipidemia in pregnant mice: implications for preeclampsia.
    9. The Chemerin/CMKLR1 Axis Is Involved in the Recruitment of Microglia to Abeta Deposition through p38 MAPK Pathway.
      Title: The Chemerin/CMKLR1 Axis Is Involved in the Recruitment of Microglia to Aβ Deposition through p38 MAPK Pathway.
    10. Epithelial chemerin-CMKLR1 signaling restricts microbiota-driven colonic neutrophilia and tumorigenesis by up-regulating lactoperoxidase.
      Title: Epithelial chemerin-CMKLR1 signaling restricts microbiota-driven colonic neutrophilia and tumorigenesis by up-regulating lactoperoxidase.
    Submit: New GeneRIF Correction See all GeneRIFs (54)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in antifungal humoral response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in antifungal innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within brown fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defense response to Gram-negative bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in embryonic digestive tract development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of chemotaxis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of macrophage chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of systemic arterial blood pressure ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of insulin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of lipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of lipid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in retinoid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    retinoic acid receptor responder protein 2
    Names
    chemerin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347167.1 → NP_001334096.1  retinoic acid receptor responder protein 2 isoform 1 preproprotein

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC154013
      Consensus CDS
      CCDS85040.1
      UniProtKB/TrEMBL
      A0A0N4SVV4
      Related
      ENSMUSP00000009425.6, ENSMUST00000009425.7
      Conserved Domains (1) summary
      cl29764
      Location:65 → 108
      Cathelicidins

    2. NM_001347168.1 → NP_001334097.1  retinoic acid receptor responder protein 2 isoform 2 preproprotein

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Variants 2 and 3 encodes the protein (isoform 2).
      Source sequence(s)
      AC154013
      Consensus CDS
      CCDS20105.1
      UniProtKB/Swiss-Prot
      Q8CHU8, Q9DD06
      Related
      ENSMUSP00000144799.2, ENSMUST00000204930.3
      Conserved Domains (1) summary
      pfam00666
      Location:65 → 108
      Cathelicidins; Cathelicidin

    3. NM_027852.3 → NP_082128.1  retinoic acid receptor responder protein 2 isoform 2 preproprotein

      See identical proteins and their annotated locations for NP_082128.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Variants 2 and 3 encodes the protein (isoform 2).
      Source sequence(s)
      AC154013
      Consensus CDS
      CCDS20105.1
      UniProtKB/Swiss-Prot
      Q8CHU8, Q9DD06
      Related
      ENSMUSP00000144793.2, ENSMUST00000204267.3
      Conserved Domains (1) summary
      pfam00666
      Location:65 → 108
      Cathelicidins; Cathelicidin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      48546630..48549778 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241467.3 → XP_011239769.1  retinoic acid receptor responder protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011239769.1

      UniProtKB/TrEMBL
      A0A0N4SVV4
      Related
      ENSMUSP00000145257.2, ENSMUST00000204182.2
      Conserved Domains (1) summary
      cl29764
      Location:65 → 108
      Cathelicidins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DD06.1 GenPept UniProtKB/Swiss-Prot:Q9DD06

    Gene LinkOut

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