Tmem79 transmembrane protein 79 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmem79provided by MGI
Official Full Name: transmembrane protein 79provided by MGI
Primary source: MGI:MGI:1919163
See related: Ensembl:ENSMUSG00000001420 AllianceGenome:MGI:1919163
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ma; Matt; 2310042N02Rik; 2310074C17Rik
Summary: Predicted to enable identical protein binding activity. Involved in several processes, including epithelial cell maturation; establishment of skin barrier; and positive regulation of epidermis development. Acts upstream of or within cornification; cuticle development; and hair follicle morphogenesis. Located in lysosomal membrane and trans-Golgi network membrane. Is expressed in alimentary system; genitourinary system; naris; skin; and thymus. Used to study atopic dermatitis. Orthologous to human TMEM79 (transmembrane protein 79). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in stomach adult (RPKM 22.5), duodenum adult (RPKM 18.0) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 38.8 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (88236351..88241761, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (88328653..88334433, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Involvement of skin TRPV3 in temperature detection regulated by TMEM79 in mice.
Title: Involvement of skin TRPV3 in temperature detection regulated by TMEM79 in mice.
Microbiota-Independent Spontaneous Dermatitis Associated with Increased Sebaceous Lipid Production in Tmem79-Deficient Mice.
Title: Microbiota-Independent Spontaneous Dermatitis Associated with Increased Sebaceous Lipid Production in Tmem79-Deficient Mice.
Dysregulated skin barrier function in Tmem79 mutant mice promotes IL-17A-dependent spontaneous skin and lung inflammation.
Title: Dysregulated skin barrier function in Tmem79 mutant mice promotes IL-17A-dependent spontaneous skin and lung inflammation.
Tmem79 has a role in oxidative stress protection.
Title: Tissue-specific contributions of Tmem79 to atopic dermatitis and mast cell-mediated histaminergic itch.
Tmem79(ma/ma) mutation is responsible for the spontaneous dermatitis phenotype in matted mice, probably as a result of impaired lamellar granule secretory system and altered stratum corneum barrier function.
Title: A homozygous nonsense mutation in the gene for Tmem79, a component for the lamellar granule secretory system, produces spontaneous eczema in an experimental model of atopic dermatitis.

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Phenotypes

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Associated conditions

Description	Tests
matted GeneReviews: Not available

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (2)
Gene trapped (1)
Targeted (3) 1 citation

General gene information

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Markers

D3Mit175 (e-PCR), detects polymorphism
- UniSTS:129592

NoName (e-PCR)
- UniSTS:234723

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cornification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cuticle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell maturation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of skin barrier	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of skin barrier	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hair follicle morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of epidermis development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulated exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulated exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in trans-Golgi network membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in trans-Golgi network membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transmembrane protein 79

Names: mattrin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.