Ctnnbip1 catenin beta interacting protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ctnnbip1provided by MGI
Official Full Name: catenin beta interacting protein 1provided by MGI
Primary source: MGI:MGI:1915756
See related: Ensembl:ENSMUSG00000028988 AllianceGenome:MGI:1915756
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Icat; Catnbip1; 1110008O09Rik; 2310001I19Rik
Summary: Enables beta-catenin binding activity. Involved in several processes, including negative regulation of DNA binding activity; negative regulation of smooth muscle cell proliferation; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including branching involved in ureteric bud morphogenesis; negative regulation of Wnt signaling pathway; and negative regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be part of beta-catenin destruction complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and respiratory system. Orthologous to human CTNNBIP1 (catenin beta interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E18 (RPKM 19.3), whole brain E14.5 (RPKM 17.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 E2; 4 79.66 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (149602698..149650894)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (149518241..149566437)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-342-5p targets CTNNBIP1 to promote enterovirus 71 replication.
Title: miR-342-5p targets CTNNBIP1 to promote enterovirus 71 replication.
Knockout of ICAT in Adipose Tissue Alleviates Fibro-inflammation in Obese Mice.
Title: Knockout of ICAT in Adipose Tissue Alleviates Fibro-inflammation in Obese Mice.
miR-215-5p is a negative regulator of adipocyte differentiation through post-transcriptional regulation of FNDC3B and CTNNBIP1 during early adipogenesis
Title: MicroRNA-215 impairs adipocyte differentiation and co-represses FNDC3B and CTNNBIP1.
miR-29b plays a pivotal role in fetal mouse neurogenesis by regulating ICAT-mediated Wnt/beta-catenin signaling.
Title: MiR-29b controls fetal mouse neurogenesis by regulating ICAT-mediated Wnt/β-catenin signaling.
Mechanistic studies revealed that CTNNBIP1 suppresses Wnt/beta-catenin signaling and that miR-215 promotes beta-catenin activation and upregulates alpha-SMA and fibronectin expression in TGF-beta1-treated MMCs by targeting CTNNBIP1
Title: Functional implications of microRNA-215 in TGF-β1-induced phenotypic transition of mesangial cells by targeting CTNNBIP1.
Inhibition of beta-catenin signaling in articular chondrocytes causes increased cell apoptosis and articular cartilage destruction in Col2a1-ICAT- transgenic mice.
Title: Inhibition of beta-catenin signaling in articular chondrocytes results in articular cartilage destruction.
These results suggest that the loss of ICAT gene function causes the arrest of UB branching and the apoptotic death of MM cells, resulting in renal agenesis.
Title: Loss of ICAT gene function leads to arrest of ureteric bud branching and renal agenesis.
ICAT plays an important role in the anteriorization of neural cells by inhibiting the posteriorizing activity of Wnt signaling
Title: Anteriorization of neural fate by inhibitor of beta-catenin and T cell factor (ICAT), a negative regulator of Wnt signaling.
Overexpression of Icat induces G(2) arrest and cell death in tumor cell mutants for adenomatous polyposis coli, beta-catenin, or Axin.
Title: Overexpression of Icat induces G(2) arrest and cell death in tumor cell mutants for adenomatous polyposis coli, beta-catenin, or Axin.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MT2058 (e-PCR)
- UniSTS:116303

NoName (e-PCR)
- UniSTS:235100

AW457332 (e-PCR)
- UniSTS:179116

D4Mit225.1 (e-PCR), detects polymorphism
- UniSTS:130005

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables armadillo repeat domain binding	ISO Inferred from Sequence Orthology more info
enables beta-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables beta-catenin binding	IPI Inferred from Physical Interaction more info	PubMed
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within anterior/posterior pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA binding	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of Wnt signaling pathway	IPI Inferred from Physical Interaction more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of mesenchymal cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein binding	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein-containing complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription initiation by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of monocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of vascular permeability involved in acute inflammatory response	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of beta-catenin destruction complex	IBA Inferred from Biological aspect of Ancestor more info
part_of beta-catenin destruction complex	ISO Inferred from Sequence Orthology more info
part_of beta-catenin-ICAT complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: beta-catenin-interacting protein 1

Names: inhibitor of beta-catenin and Tcf-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001141930.1 → NP_001135402.1 beta-catenin-interacting protein 1

See identical proteins and their annotated locations for NP_001135402.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK003595, AK048258, BQ031304, BQ043263

Consensus CDS

CCDS38975.1

UniProtKB/Swiss-Prot

Q9JJN6

Related

ENSMUSP00000101317.2, ENSMUST00000105692.2

Conserved Domains (1) summary

pfam06384
Location:1 → 79

ICAT; Beta-catenin-interacting protein ICAT
NM_023465.4 → NP_075954.1 beta-catenin-interacting protein 1

See identical proteins and their annotated locations for NP_075954.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK036181, BQ031304

Consensus CDS

CCDS38975.1

UniProtKB/Swiss-Prot

Q9JJN6

Related

ENSMUSP00000030839.7, ENSMUST00000030839.13

Conserved Domains (1) summary

pfam06384
Location:1 → 79

ICAT; Beta-catenin-interacting protein ICAT