Spatc1l spermatogenesis and centriole associated 1 like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Spatc1lprovided by MGI
Official Full Name: spermatogenesis and centriole associated 1 likeprovided by MGI
Primary source: MGI:MGI:1923823
See related: Ensembl:ENSMUSG00000009115 AllianceGenome:MGI:1923823
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1700022B01Rik; 1700027D21Rik
Summary: Enables protein kinase A regulatory subunit binding activity. Acts upstream of or within several processes, including actin polymerization or depolymerization; positive regulation of cAMP-dependent protein kinase activity; and positive regulation of protein kinase A signaling. Located in centrosome and sperm connecting piece. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human SPATC1L (spermatogenesis and centriole associated 1 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward testis adult (RPKM 108.1) See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.2 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (76394180..76406035)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (76561993..76570201)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these results implicate the SPATC1L-PKA complex in maintaining the stability of the sperm head-tail junction, thereby revealing a new molecular basis for sperm head-tail integrity.
Title: SPATC1L maintains the integrity of the sperm head-tail junction.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

General gene information

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Markers

1700027D21Rik (e-PCR), detects polymorphism
- UniSTS:259017

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase A regulatory subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase A regulatory subunit binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin polymerization or depolymerization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cAMP-dependent protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein kinase A signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of protein kinase A signaling	IPI Inferred from Physical Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in spermatogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in sperm connecting piece	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm connecting piece	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: speriolin-like protein

Names: spermatogenesis and centriole-associated protein 1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359186.1 → NP_001346115.1 speriolin-like protein isoform 2

Status: VALIDATED

Source sequence(s)

AK006232, AK006410, BX636056

Consensus CDS

CCDS88029.1

UniProtKB/TrEMBL

D3Z7D4

Related

ENSMUSP00000101054.2, ENSMUST00000105414.2

Conserved Domains (1) summary

pfam15058
Location:5 → 155

Speriolin_N; Speriolin N terminus
NM_029661.1 → NP_083937.1 speriolin-like protein isoform 1

See identical proteins and their annotated locations for NP_083937.1

Status: VALIDATED

Source sequence(s)

AK006410

Consensus CDS

CCDS23949.1

UniProtKB/Swiss-Prot

B2RW50, Q9D9W0

Related

ENSMUSP00000009259.5, ENSMUST00000009259.5

Conserved Domains (2) summary

pfam15058
Location:5 → 155

Speriolin_N; Speriolin N terminus

pfam15059
Location:197 → 342

Speriolin_C; Speriolin C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

76394180..76406035

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017314142.3 → XP_017169631.1 speriolin-like protein isoform X2

Conserved Domains (2) summary

pfam15058
Location:1 → 41

Speriolin_N; Speriolin N-terminus

pfam15059
Location:83 → 228

Speriolin_C; Speriolin C-terminus
XM_006514279.3 → XP_006514342.1 speriolin-like protein isoform X1

Conserved Domains (2) summary

pfam15058
Location:3 → 89

Speriolin_N; Speriolin N-terminus

pfam15059
Location:131 → 276

Speriolin_C; Speriolin C-terminus