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    Urgcp upregulator of cell proliferation [ Mus musculus (house mouse) ]

    Gene ID: 72046, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Urgcpprovided by MGI
    Official Full Name
    upregulator of cell proliferationprovided by MGI
    Primary source
    MGI:MGI:1919296
    See related
    Ensembl:ENSMUSG00000049680 AllianceGenome:MGI:1919296
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Urg4; mKIAA1507; 2010005J08Rik; 9130001I21Rik
    Summary
    Predicted to enable GTP binding activity. Predicted to be located in cytosol. Orthologous to human URGCP (upregulator of cell proliferation). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 12.8), duodenum adult (RPKM 12.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 A1; 11 3.87 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (5663417..5712376, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (5713417..5762376, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53663 Neighboring gene mitochondrial ribosomal protein S24 Neighboring gene STARR-seq mESC enhancer starr_28441 Neighboring gene STARR-positive B cell enhancer ABC_E8385 Neighboring gene ubiquitin-conjugating enzyme E2D, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6945 Neighboring gene drebrin-like Neighboring gene STARR-seq mESC enhancer starr_28442 Neighboring gene phosphoglycerate mutase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    2. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767
    3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    up-regulator of cell proliferation
    Names
    HBV X protein up-regulated gene 4 protein homolog
    HBxAg up-regulated gene 4 protein homolog
    protein URG4

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077661.1 → NP_001071129.1  up-regulator of cell proliferation isoform 2

      See identical proteins and their annotated locations for NP_001071129.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Variants 2-6 all encode the same isoform (2).
      Source sequence(s)
      AK041953, AL627069, BC066994
      Consensus CDS
      CCDS36105.1
      UniProtKB/TrEMBL
      Q6ZPP3
      Related
      ENSMUSP00000113060.2, ENSMUST00000120306.8
      Conserved Domains (2) summary
      cl27170
      Location:364 → 498
      DUF460; Protein of unknown function (DUF460)
      cl38936
      Location:649 → 749
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001361588.1 → NP_001348517.1  up-regulator of cell proliferation isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Variants 2-6 all encode the same isoform (2).
      Source sequence(s)
      AK041953, AL627069
      Consensus CDS
      CCDS36105.1
      UniProtKB/TrEMBL
      Q6ZPP3
      Related
      ENSMUSP00000113589.2, ENSMUST00000118076.8
      Conserved Domains (2) summary
      cl27170
      Location:364 → 498
      DUF460; Protein of unknown function (DUF460)
      cl38936
      Location:649 → 749
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. NM_001361589.1 → NP_001348518.1  up-regulator of cell proliferation isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Variants 2-6 all encode the same isoform (2).
      Source sequence(s)
      AL627069
      Consensus CDS
      CCDS36105.1
      UniProtKB/TrEMBL
      Q6ZPP3
      Conserved Domains (2) summary
      cl27170
      Location:364 → 498
      DUF460; Protein of unknown function (DUF460)
      cl38936
      Location:649 → 749
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    4. NM_001361590.1 → NP_001348519.1  up-regulator of cell proliferation isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Variants 2-6 all encode the same isoform (2).
      Source sequence(s)
      AL627069, BY036098
      Consensus CDS
      CCDS36105.1
      UniProtKB/TrEMBL
      Q6ZPP3
      Conserved Domains (2) summary
      cl27170
      Location:364 → 498
      DUF460; Protein of unknown function (DUF460)
      cl38936
      Location:649 → 749
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    5. NM_001361591.1 → NP_001348520.1  up-regulator of cell proliferation isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Variants 2-6 all encode the same isoform (2).
      Source sequence(s)
      AL627069, BY339716
      Consensus CDS
      CCDS36105.1
      UniProtKB/TrEMBL
      Q6ZPP3
      Conserved Domains (2) summary
      cl27170
      Location:364 → 498
      DUF460; Protein of unknown function (DUF460)
      cl38936
      Location:649 → 749
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    6. NM_001361592.1 → NP_001348521.1  up-regulator of cell proliferation isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL627069, DN174878
      UniProtKB/TrEMBL
      Q6ZPP3
      Conserved Domains (2) summary
      cl27170
      Location:332 → 466
      DUF460; Protein of unknown function (DUF460)
      cl38936
      Location:617 → 717
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    7. NM_178623.3 → NP_848738.2  up-regulator of cell proliferation isoform 1

      See identical proteins and their annotated locations for NP_848738.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL627069, BY058620
      Consensus CDS
      CCDS36104.1
      UniProtKB/Swiss-Prot
      A0PJ66, Q3TLI5, Q5NCI0, Q8C9K3, Q8CBP7, Q8CC98
      UniProtKB/TrEMBL
      Q6ZPP3
      Related
      ENSMUSP00000091053.6, ENSMUST00000093362.12
      Conserved Domains (1) summary
      cl21455
      Location:692 → 792
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      5663417..5712376 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157006.1 → XP_036012899.1  up-regulator of cell proliferation isoform X3

      UniProtKB/TrEMBL
      Q6ZPP3
      Conserved Domains (2) summary
      cl27170
      Location:364 → 498
      DUF460; Protein of unknown function (DUF460)
      cl38936
      Location:649 → 749
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. XM_006514815.4 → XP_006514878.1  up-regulator of cell proliferation isoform X3

      See identical proteins and their annotated locations for XP_006514878.1

      UniProtKB/TrEMBL
      Q6ZPP3
      Conserved Domains (2) summary
      cl27170
      Location:364 → 498
      DUF460; Protein of unknown function (DUF460)
      cl38936
      Location:649 → 749
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. XM_011243755.4 → XP_011242057.1  up-regulator of cell proliferation isoform X3

      See identical proteins and their annotated locations for XP_011242057.1

      UniProtKB/TrEMBL
      Q6ZPP3
      Conserved Domains (2) summary
      cl27170
      Location:364 → 498
      DUF460; Protein of unknown function (DUF460)
      cl38936
      Location:649 → 749
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    4. XM_011243754.4 → XP_011242056.1  up-regulator of cell proliferation isoform X2

      UniProtKB/TrEMBL
      Q6ZPP3
      Conserved Domains (2) summary
      cl27170
      Location:373 → 507
      DUF460; Protein of unknown function (DUF460)
      cl38936
      Location:658 → 758
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    5. XM_011243753.3 → XP_011242055.1  up-regulator of cell proliferation isoform X1

      UniProtKB/TrEMBL
      Q6ZPP3
      Conserved Domains (2) summary
      cl27170
      Location:377 → 511
      DUF460; Protein of unknown function (DUF460)
      cl38936
      Location:662 → 762
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    6. XM_011243757.3 → XP_011242059.1  up-regulator of cell proliferation isoform X4

      See identical proteins and their annotated locations for XP_011242059.1

      UniProtKB/TrEMBL
      Q6ZPP3
      Conserved Domains (2) summary
      cl27170
      Location:332 → 466
      DUF460; Protein of unknown function (DUF460)
      cl38936
      Location:617 → 717
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5NCI0.1 GenPept UniProtKB/Swiss-Prot:Q5NCI0

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