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    Trmt2b TRM2 tRNA methyltransferase 2B [ Mus musculus (house mouse) ]

    Gene ID: 215201, updated on 12-May-2024

    Summary

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    Official Symbol
    Trmt2bprovided by MGI
    Official Full Name
    TRM2 tRNA methyltransferase 2Bprovided by MGI
    Primary source
    MGI:MGI:2442530
    See related
    Ensembl:ENSMUSG00000067369 AllianceGenome:MGI:2442530
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4732479N06Rik
    Summary
    Predicted to enable S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity. Predicted to be involved in RNA processing. Predicted to act upstream of or within methylation and tRNA processing. Located in mitochondrion. Is expressed in olfactory cortex ventricular layer and telencephalon ventricular layer. Orthologous to human TRMT2B (tRNA methyltransferase 2 homolog B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in heart adult (RPKM 10.8), bladder adult (RPKM 6.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    X E3; X 55.95 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (133123704..133177770, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (134222955..134277023, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene X-linked Kx blood group related, X-linked Neighboring gene STARR-seq mESC enhancer starr_47954 Neighboring gene ADP-ribosylation factor-like 13A Neighboring gene STARR-seq mESC enhancer starr_47955 Neighboring gene transmembrane protein 35A Neighboring gene centromere protein I

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse Trmt2B protein is a dual specific mitochondrial metyltransferase responsible for m(5)U formation in both tRNA and rRNA. Laptev I, et al. RNA Biol, 2020 Apr. PMID 31736397, Free PMC Article
    2. Epigenetic functions of smchd1 repress gene clusters on the inactive X chromosome and on autosomes. Gendrel AV, et al. Mol Cell Biol, 2013 Aug. PMID 23754746, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mouse Trmt2B protein is a dual specific mitochondrial metyltransferase responsible for m(5)U formation in both tRNA and rRNA.
      Title: Mouse Trmt2B protein is a dual specific mitochondrial metyltransferase responsible for m(5)U formation in both tRNA and rRNA.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA (uridine-C5-)-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables rRNA (uridine-C5-)-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tRNA (uracil-5-)-methyltransferase homolog B
    Names
    TRM2 homolog
    TRM2 homolog B
    TRM2 tRNA methyltransferase 2 homolog B
    rRNA (uracil-5-)-methyltransferase TRMT2B
    tRNA (uracil(54)-C(5))-methyltransferase homolog
    tRNA (uracil-5-)-methyltransferase homolog
    NP_001161466.1
    NP_001161467.1
    NP_766128.2
    XP_006528577.1
    XP_011246036.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001167994.1 → NP_001161466.1  tRNA (uracil-5-)-methyltransferase homolog B isoform a

      See identical proteins and their annotated locations for NP_001161466.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode isoform a.
      Source sequence(s)
      AK028999, AK046928, BC056937
      Consensus CDS
      CCDS41121.1
      UniProtKB/Swiss-Prot
      Q8BQJ6, Q8CE55
      UniProtKB/TrEMBL
      S4R2E5
      Related
      ENSMUSP00000108878.2, ENSMUST00000113252.8
      Conserved Domains (2) summary
      COG2265
      Location:83 → 486
      TrmA; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]
      cl17173
      Location:290 → 490
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. NM_001167995.1 → NP_001161467.1  tRNA (uracil-5-)-methyltransferase homolog B isoform b

      See identical proteins and their annotated locations for NP_001161467.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AI835629, AK046928
      Consensus CDS
      CCDS53183.1
      UniProtKB/TrEMBL
      Q8C8J3
      Related
      ENSMUSP00000084819.4, ENSMUST00000087540.4

    3. NM_172540.2 → NP_766128.2  tRNA (uracil-5-)-methyltransferase homolog B isoform a

      See identical proteins and their annotated locations for NP_766128.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode isoform a.
      Source sequence(s)
      AK028999, AK046928, AK049523
      Consensus CDS
      CCDS41121.1
      UniProtKB/Swiss-Prot
      Q8BQJ6, Q8CE55
      UniProtKB/TrEMBL
      S4R2E5
      Related
      ENSMUSP00000084820.6, ENSMUST00000087541.12
      Conserved Domains (2) summary
      COG2265
      Location:83 → 486
      TrmA; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]
      cl17173
      Location:290 → 490
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      133123704..133177770 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247734.4 → XP_011246036.1  tRNA (uracil-5-)-methyltransferase homolog B isoform X2

      UniProtKB/TrEMBL
      S4R2E5
      Related
      ENSMUSP00000138612.2, ENSMUST00000128115.8
      Conserved Domains (1) summary
      COG2265
      Location:83 → 418
      TrmA; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]

    2. XM_006528514.5 → XP_006528577.1  tRNA (uracil-5-)-methyltransferase homolog B isoform X1

      UniProtKB/TrEMBL
      S4R2E5
      Conserved Domains (1) summary
      COG2265
      Location:83 → 441
      TrmA; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BQJ6.1 GenPept UniProtKB/Swiss-Prot:Q8BQJ6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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