Akr1a1 aldo-keto reductase family 1, member A1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Akr1a1provided by MGI
Official Full Name: aldo-keto reductase family 1, member A1provided by MGI
Primary source: MGI:MGI:1929955
See related: Ensembl:ENSMUSG00000028692 AllianceGenome:MGI:1929955
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Akr1a4; 2610201A18Rik
Summary: Enables L-glucuronate reductase activity; alditol:NADP+ 1-oxidoreductase activity; and glucuronolactone reductase activity. Involved in cellular detoxification of aldehyde. Acts upstream of or within D-glucuronate catabolic process; L-ascorbic acid biosynthetic process; and aldehyde catabolic process. Located in apical plasma membrane and cytosol. Is active in synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Orthologous to human AKR1A1 (aldo-keto reductase family 1 member A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in kidney adult (RPKM 1079.8), large intestine adult (RPKM 404.9) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D1; 4 53.26 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (116493707..116508871, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (116636510..116651674, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The concerted elevation of conjugation reactions is associated with the aggravation of acetaminophen toxicity in Akr1a-knockout mice with an ascorbate insufficiency.
Title: The concerted elevation of conjugation reactions is associated with the aggravation of acetaminophen toxicity in Akr1a-knockout mice with an ascorbate insufficiency.
Developmental retardation in neonates of aldehyde reductase (AKR1A)-deficient mice is associated with low ascorbic acid and high corticosterone levels.
Title: Developmental retardation in neonates of aldehyde reductase (AKR1A)-deficient mice is associated with low ascorbic acid and high corticosterone levels.
genetic ablation of AKR1A activates the PGC-1alpha pathway and spare glucose, which would consequently confer exercise endurance
Title: Genetic ablation of aldehyde reductase (Akr1a) augments exercise endurance in mice via activation of the PGC-1α-involved pathway.
Data (including data from studies in knockout and transgenic mice) suggest that Akr1a1 in liver is involved in bioactivation of xenobiotic/carcinogen thioacetamide (TAA); Akr1a-/- knockout mice are resistant to TAA-induced liver injury/hepatotoxicity.
Title: Mice deficient in aldo-keto reductase 1a (Akr1a) are resistant to thioacetamide-induced liver injury.
Akr1A1 gene knockout mice exhibit insufficient serum ascorbic acid levels, abnormal bone development and osteoporosis.
Title: A novel osteoporosis model with ascorbic acid deficiency in Akr1A1 gene knockout mice.
These results suggest that Akr1a might be involved in the metabolism of steroids and other carbonyl-containing compounds.
Title: Heightened aggressive behavior in mice deficient in aldo-keto reductase 1a (Akr1a).
Aldehyde reductase exerts a protective effect against carbon tetrachloride-induced hepatic steatosis by replenishing ascorbic acid via its antioxidative properties.
Title: Ablation of aldehyde reductase aggravates carbon tetrachloride-induced acute hepatic injury involving oxidative stress and endoplasmic reticulum stress.
The crystal structure of AKR1a4 in its apo form at high resolution.
Title: High-resolution structure of AKR1a4 in the apo form and its interaction with ligands.
A novel mechanism of regulation of oxidative stress by ATM through modulation of SMAR1-AKR1a4 complex, is proposed.
Title: SMAR1 regulates free radical stress through modulation of AKR1a4 enzyme activity.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (2)
Targeted (2) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

Akr1a1 (e-PCR), detects polymorphism
- UniSTS:546643

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-glucuronate reductase activity	IDA Inferred from Direct Assay more info	PubMed
enables L-glucuronate reductase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables L-glucuronate reductase activity	ISO Inferred from Sequence Orthology more info
enables S-nitrosoglutathione reductase (NADH) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables alcohol dehydrogenase (NADP+) activity	NAS Non-traceable Author Statement more info	PubMed
enables aldose reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables aldose reductase (NADPH) activity	IDA Inferred from Direct Assay more info	PubMed
enables aldose reductase (NADPH) activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables aldose reductase (NADPH) activity	TAS Traceable Author Statement more info	PubMed
enables allyl-alcohol dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables glucuronolactone reductase activity	IDA Inferred from Direct Assay more info	PubMed
enables glucuronolactone reductase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within D-glucuronate catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in D-glucuronate catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within L-ascorbic acid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in L-ascorbic acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in L-ascorbic acid biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within aldehyde catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular detoxification of aldehyde	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular detoxification of aldehyde	ISO Inferred from Sequence Orthology more info
involved_in daunorubicin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in doxorubicin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glucuronate catabolic process to xylulose 5-phosphate	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: aldo-keto reductase family 1 member A1

Names: alcohol dehydrogenase; aldehyde reductase; aldo-keto reductase family 1, member A4 (aldehyde reductase); glucuronate reductase; glucuronolactone reductase

NP_067448.1

EC 1.1.1.19

EC 1.1.1.2

EC 1.1.1.20

EC 1.1.1.372

EC 1.1.1.54

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021473.3 → NP_067448.1 aldo-keto reductase family 1 member A1

See identical proteins and their annotated locations for NP_067448.1

Status: VALIDATED

Source sequence(s)

AK164461, AL831786, BC046762, BY329410

Consensus CDS

CCDS18514.1

UniProtKB/Swiss-Prot

Q9CQI5, Q9CQT8, Q9CT53, Q9D012, Q9D016, Q9D0I7, Q9D0P3, Q9JII6

UniProtKB/TrEMBL

Q3UJW9, Q540D7, Q80XJ7

Related

ENSMUSP00000030455.9, ENSMUST00000030455.15

Conserved Domains (2) summary

COG0656
Location:1 → 303

ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]

COG0667
Location:9 → 291

Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]