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    Scai suppressor of cancer cell invasion [ Mus musculus (house mouse) ]

    Gene ID: 320271, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Scaiprovided by MGI
    Official Full Name
    suppressor of cancer cell invasionprovided by MGI
    Primary source
    MGI:MGI:2443716
    See related
    Ensembl:ENSMUSG00000035236 AllianceGenome:MGI:2443716
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9330112M16; A930041I02Rik
    Summary
    Enables transcription corepressor activity. Involved in negative regulation of Rho protein signal transduction and negative regulation of cell migration. Located in cytoplasm and nucleus. Is expressed in olfactory epithelium. Orthologous to human SCAI (suppressor of cancer cell invasion). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E18 (RPKM 4.6), limb E14.5 (RPKM 4.6) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 B; 2 24.42 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (38956226..39080770, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (39066214..39190758, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5911 Neighboring gene STARR-positive B cell enhancer ABC_E4447 Neighboring gene STARR-positive B cell enhancer mm9_chr2:38866813-38867114 Neighboring gene actin related protein 2/3 complex, subunit 5-like Neighboring gene golgin A1 Neighboring gene predicted gene, 26127 Neighboring gene STARR-positive B cell enhancer ABC_E9512 Neighboring gene predicted gene, 30067 Neighboring gene STARR-seq mESC enhancer starr_04343 Neighboring gene developmental pluripotency associated 4 pseudogene Neighboring gene mitochondrial ribosomal protein L40 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3372 Neighboring gene protein phosphatase 6, catalytic subunit Neighboring gene STARR-seq mESC enhancer starr_04346 Neighboring gene STARR-seq mESC enhancer starr_04347 Neighboring gene vomeronasal 2, receptor, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Protexin complex counters resection on stalled forks to promote homologous recombination and crosslink repair. Adeyemi RO, et al. Mol Cell, 2021 Nov 4. PMID 34597596, Free PMC Article
    2. SCAI promotes DNA double-strand break repair in distinct chromosomal contexts. Hansen RK, et al. Nat Cell Biol, 2016 Dec. PMID 27820601, Free PMC Article
    3. Characterization and role of SCAI during renal fibrosis and epithelial-to-mesenchymal transition. Fintha A, et al. Am J Pathol, 2013 Feb. PMID 23178076
    4. SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin. Brandt DT, et al. Nat Cell Biol, 2009 May. PMID 19350017
    5. Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes. Ostapcuk V, et al. Nature, 2018 May. PMID 29795351

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Protexin complex counters resection on stalled forks to promote homologous recombination and crosslink repair.
      Title: The Protexin complex counters resection on stalled forks to promote homologous recombination and crosslink repair.
    2. SCAI (suppressor of cancer cell invasion) is identified as a 53BP1-interacting chromatin-associated protein that promotes the functionality of several DNA double-strand breaks repair pathways in mammalian cells.
      Title: SCAI promotes DNA double-strand break repair in distinct chromosomal contexts.
    3. SCAI is a novel transcriptional cofactor that regulates epithelial-to-mesenchymal transition and renal fibrosis.
      Title: Characterization and role of SCAI during renal fibrosis and epithelial-to-mesenchymal transition.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of Rho protein signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of cell migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein SCAI
    Names
    suppressor of cancer cell invasion protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399623.1 → NP_001386552.1  protein SCAI isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL844588, AL845350, AL928639

    2. NM_001399624.1 → NP_001386553.1  protein SCAI isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL844588, AL845350, AL928639

    3. NM_001399625.1 → NP_001386554.1  protein SCAI isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL844588, AL845350, AL928639

    4. NM_178778.4 → NP_848893.2  protein SCAI isoform 1

      See identical proteins and their annotated locations for NP_848893.2

      Status: VALIDATED

      Source sequence(s)
      AL844588, AL845350, AL928639
      Consensus CDS
      CCDS38121.1
      UniProtKB/Swiss-Prot
      A2RTF5, A3KGQ2, Q8C409, Q8C8K2, Q8C8N2
      UniProtKB/TrEMBL
      Q8C4E7
      Related
      ENSMUSP00000037194.6, ENSMUST00000038874.12
      Conserved Domains (1) summary
      pfam12070
      Location:64 → 557
      SCAI; Protein SCAI

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      38956226..39080770 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162303.1 → XP_036018196.1  protein SCAI isoform X4

      UniProtKB/TrEMBL
      Q3TQB4
      Conserved Domains (1) summary
      pfam12070
      Location:64 → 357
      SCAI; Protein SCAI

    2. XM_036162305.1 → XP_036018198.1  protein SCAI isoform X6

      UniProtKB/TrEMBL
      Q3TQB4
      Conserved Domains (1) summary
      pfam12070
      Location:64 → 357
      SCAI; Protein SCAI

    3. XM_036162302.1 → XP_036018195.1  protein SCAI isoform X3

      UniProtKB/TrEMBL
      A0A0N4SVJ6
      Conserved Domains (1) summary
      pfam12070
      Location:64 → 446
      SCAI; Protein SCAI

    4. XM_036162301.1 → XP_036018194.1  protein SCAI isoform X3

      UniProtKB/TrEMBL
      A0A0N4SVJ6
      Conserved Domains (1) summary
      pfam12070
      Location:64 → 446
      SCAI; Protein SCAI

    5. XM_036162304.1 → XP_036018197.1  protein SCAI isoform X5

      UniProtKB/TrEMBL
      Q3TQB4
      Conserved Domains (1) summary
      pfam12070
      Location:64 → 357
      SCAI; Protein SCAI

    6. XM_036162299.1 → XP_036018192.1  protein SCAI isoform X1

      UniProtKB/TrEMBL
      A0A0N4SVJ6
      Related
      ENSMUSP00000145133.2, ENSMUST00000204093.3
      Conserved Domains (1) summary
      pfam12070
      Location:64 → 468
      SCAI; Protein SCAI

    7. XM_036162300.1 → XP_036018193.1  protein SCAI isoform X2

      Conserved Domains (1) summary
      pfam12070
      Location:64 → 357
      SCAI; Protein SCAI
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C8N2.2 GenPept UniProtKB/Swiss-Prot:Q8C8N2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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