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    Elovl7 ELOVL fatty acid elongase 7 [ Mus musculus (house mouse) ]

    Gene ID: 74559, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Elovl7provided by MGI
    Official Full Name
    ELOVL fatty acid elongase 7provided by MGI
    Primary source
    MGI:MGI:1921809
    See related
    Ensembl:ENSMUSG00000021696 AllianceGenome:MGI:1921809
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9130013K24Rik
    Summary
    Predicted to enable fatty acid elongase activity. Predicted to be involved in fatty acid biosynthetic process and sphingolipid biosynthetic process. Predicted to act upstream of or within fatty acid biosynthetic process. Predicted to be located in endoplasmic reticulum. Predicted to be integral component of endoplasmic reticulum membrane. Is expressed in 4th ventricle lateral recess; choroid plexus; lateral ventricle choroid plexus; and skin. Orthologous to human ELOVL7 (ELOVL fatty acid elongase 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in large intestine adult (RPKM 5.6), kidney adult (RPKM 5.5) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    13 D2.1; 13 59.69 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (108350860..108423643)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (108214326..108287109)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 2 Neighboring gene STARR-positive B cell enhancer mm9_chr13:108943188-108943489 Neighboring gene predicted gene, 52057 Neighboring gene STARR-positive B cell enhancer ABC_E5415 Neighboring gene excision repaiross-complementing rodent repair deficiency, complementation group 8 Neighboring gene STARR-seq mESC enhancer starr_35596 Neighboring gene predicted gene, 32376 Neighboring gene predicted gene, 30747 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:109087570-109087807 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:109087883-109088036 Neighboring gene STARR-positive B cell enhancer mm9_chr13:109106315-109106616 Neighboring gene neuroepithelial cell transforming gene 1 pseudogene Neighboring gene DEP domain containing 1B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Reactivation of androgen receptor-regulated lipid biosynthesis drives the progression of castration-resistant prostate cancer. Han W, et al. Oncogene, 2018 Feb 8. PMID 29059155, Free PMC Article
    2. Production of branched-chain very-long-chain fatty acids by fatty acid elongases and their tissue distribution in mammals. Tanno H, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2021 Jan. PMID 33069870
    3. Impaired epidermal permeability barrier in mice lacking elovl1, the gene responsible for very-long-chain fatty acid production. Sassa T, et al. Mol Cell Biol, 2013 Jul. PMID 23689133, Free PMC Article
    4. The Transcription Factors EBF1 and EBF2 Are Positive Regulators of Myelination in Schwann Cells. Moruzzo D, et al. Mol Neurobiol, 2017 Dec. PMID 27889898
    5. Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil. Lau CG, et al. Mol Reprod Dev, 2014 Nov. PMID 25269881

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Production of branched-chain very-long-chain fatty acids by fatty acid elongases and their tissue distribution in mammals.
      Title: Production of branched-chain very-long-chain fatty acids by fatty acid elongases and their tissue distribution in mammals.
    2. High Elovl7 expression is associated with progression of castration-resistant prostate cancer.
      Title: Reactivation of androgen receptor-regulated lipid biosynthesis drives the progression of castration-resistant prostate cancer.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables fatty acid elongase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty acid elongase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid elongation, monounsaturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid elongation, polyunsaturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid elongation, polyunsaturated fatty acid ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid elongation, saturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid elongation, saturated fatty acid ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sphingolipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in very long-chain fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in very long-chain fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    very long chain fatty acid elongase 7
    Names
    3-keto acyl-CoA synthase Elovl7
    ELOVL FA elongase 7
    ELOVL family member 7, elongation of long chain fatty acids
    elongation of very long chain fatty acids protein 7
    elongation of very long chain fatty acids-like 7
    very long chain 3-ketoacyl-CoA synthase 7
    very long chain 3-oxoacyl-CoA synthase 7
    NP_083277.3
    XP_006517841.1
    XP_036014092.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029001.5 → NP_083277.3  very long chain fatty acid elongase 7

      See identical proteins and their annotated locations for NP_083277.3

      Status: VALIDATED

      Source sequence(s)
      AC161252, AK018616, AK049118, BQ175164
      Consensus CDS
      CCDS36779.1
      UniProtKB/Swiss-Prot
      Q8BX38, Q8BYY8, Q9D2Y9
      Related
      ENSMUSP00000022207.9, ENSMUST00000022207.10
      Conserved Domains (1) summary
      pfam01151
      Location:30 → 269
      ELO; GNS1/SUR4 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      108350860..108423643
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517778.4 → XP_006517841.1  very long chain fatty acid elongase 7 isoform X2

      Conserved Domains (1) summary
      pfam01151
      Location:1 → 182
      ELO; GNS1/SUR4 family

    2. XM_036158199.1 → XP_036014092.1  very long chain fatty acid elongase 7 isoform X1

      Conserved Domains (1) summary
      pfam01151
      Location:1 → 239
      ELO; GNS1/SUR4 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D2Y9.1 GenPept UniProtKB/Swiss-Prot:Q9D2Y9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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