Kcnma1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcnma1provided by MGI
Official Full Name: potassium large conductance calcium-activated channel, subfamily M, alpha member 1provided by MGI
Primary source: MGI:MGI:99923
See related: Ensembl:ENSMUSG00000063142 AllianceGenome:MGI:99923
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Slo; BKCa; Slo1; mSlo; MaxiK; mSlo1; KCa1.1; slo-alpha; BKCA alpha; k(VCA)alpha; 5730414M22Rik
Summary: Enables identical protein binding activity; large conductance calcium-activated potassium channel activity; and voltage-gated potassium channel activity. Acts upstream of or within several processes, including adult walking behavior; eye blink reflex; and locomotor rhythm. Located in several cellular components, including apical plasma membrane; external side of plasma membrane; and postsynaptic membrane. Is integral component of membrane. Part of voltage-gated potassium channel complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in Alzheimer's disease and idiopathic generalized epilepsy. Orthologous to human KCNMA1 (potassium calcium-activated channel subfamily M alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cortex adult (RPKM 10.4), frontal lobe adult (RPKM 9.3) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 A3; 14 12.92 cM

Exon count:: 36

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (23342356..24055173, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (23292288..24005110, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Downregulation of KCNMA1 in mice accelerates auditory hair cells senescence via ferroptosis.
Title: Downregulation of KCNMA1 in mice accelerates auditory hair cells senescence via ferroptosis.
Slo1 deficiency impaired skeletal muscle regeneration and slow-twitch fibre formation.
Title: Slo1 deficiency impaired skeletal muscle regeneration and slow-twitch fibre formation.
Hyperacusis in the Adult Fmr1-KO Mouse Model of Fragile X Syndrome: The Therapeutic Relevance of Cochlear Alterations and BKCa Channels.
Title: Hyperacusis in the Adult Fmr1-KO Mouse Model of Fragile X Syndrome: The Therapeutic Relevance of Cochlear Alterations and BKCa Channels.
Kcnma1 is involved in mitochondrial homeostasis in diabetes-related skeletal muscle atrophy.
Title: Kcnma1 is involved in mitochondrial homeostasis in diabetes-related skeletal muscle atrophy.
BK channel properties correlate with neurobehavioral severity in three KCNMA1-linked channelopathy mouse models.
Title: BK channel properties correlate with neurobehavioral severity in three KCNMA1-linked channelopathy mouse models.
Erectile Dysfunction and Altered Contribution of KCa1.1 and KCa2.3 Channels in the Penile Tissue of Type-2 Diabetic db/db Mice.
Title: Erectile Dysfunction and Altered Contribution of KCa1.1 and KCa2.3 Channels in the Penile Tissue of Type-2 Diabetic db/db Mice.
BK Channel Deficiency in Osteoblasts Reduces Bone Formation via the Wnt/beta-Catenin Pathway.
Title: BK Channel Deficiency in Osteoblasts Reduces Bone Formation via the Wnt/β-Catenin Pathway.
Upregulated LRRC55 promotes BK channel activation and aggravates cell injury in podocytes.
Title: Upregulated LRRC55 promotes BK channel activation and aggravates cell injury in podocytes.
Intercalated cell BKalpha subunit is required for flow-induced K+ secretion.
Title: Intercalated cell BKα subunit is required for flow-induced K+ secretion.
BK ablation attenuates osteoblast bone formation via integrin pathway.
Title: BK ablation attenuates osteoblast bone formation via integrin pathway.

Submit: New GeneRIF Correction See all GeneRIFs (113)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (11) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Kcnma1 (e-PCR), detects polymorphism
- UniSTS:143672

D14Mit208 (e-PCR), detects polymorphism
- UniSTS:127321

D14Mit221 (e-PCR), detects polymorphism
- UniSTS:127335

D15M14Mit222 (e-PCR)
- UniSTS:127336

D14Mit222 (e-PCR), detects polymorphism
- UniSTS:127336

Kcnma1 (e-PCR), detects polymorphism
- UniSTS:516539

Kcnma1 (e-PCR), detects polymorphism
- UniSTS:516540

Kcnma1 (e-PCR), detects polymorphism
- UniSTS:516541

Kcnma1 (e-PCR), detects polymorphism
- UniSTS:516542

Kcnma1 (e-PCR), detects polymorphism
- UniSTS:516543

Kcnma1 (e-PCR), detects polymorphism
- UniSTS:516544

NoName (e-PCR)
- UniSTS:224705

Kcnma1 (e-PCR), detects polymorphism
- UniSTS:516545

WI-18797 (e-PCR)
- UniSTS:36809

U09383 (e-PCR)
- UniSTS:125659

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	ISO Inferred from Sequence Orthology more info
enables calcium-activated potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium-activated potassium channel activity	IGI Inferred from Genetic Interaction more info	PubMed
enables calcium-activated potassium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables calcium-activated potassium channel activity	ISO Inferred from Sequence Orthology more info
enables calcium-activated potassium channel activity	TAS Traceable Author Statement more info
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables large conductance calcium-activated potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables large conductance calcium-activated potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables large conductance calcium-activated potassium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables large conductance calcium-activated potassium channel activity	ISO Inferred from Sequence Orthology more info
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables potassium channel activity	IGI Inferred from Genetic Interaction more info	PubMed
enables potassium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated potassium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adult walking behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in blood vessel diameter maintenance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within columnar/cuboidal epithelial cell maturation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within eye blink reflex	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner ear auditory receptor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular potassium ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within locomotor rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within micturition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in micturition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cell volume	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell volume	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of small intestine smooth muscle contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuromuscular process controlling balance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron maturation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuronal action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within potassium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within potassium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of aldosterone metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of membrane potential	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of membrane potential	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of membrane potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within relaxation of vascular associated smooth muscle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in response to carbon monoxide	ISO Inferred from Sequence Orthology more info
involved_in response to estrogen	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in response to osmotic stress	ISO Inferred from Sequence Orthology more info
involved_in response to pH	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within saliva secretion	IGI Inferred from Genetic Interaction more info	PubMed
NOT acts_upstream_of_or_within sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within smooth muscle contraction involved in micturition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in smooth muscle contraction involved in micturition	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in vasodilation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within vasodilation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vasodilation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IC Inferred by Curator more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in sarcoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated potassium channel complex	IGI Inferred from Genetic Interaction more info	PubMed
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: calcium-activated potassium channel subunit alpha-1

Names: BK channel alpha subunit; calcium-activated potassium channel, subfamily M subunit alpha-1; maxi K channel; slo homolog; slowpoke homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001253358.1 → NP_001240287.1 calcium-activated potassium channel subunit alpha-1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC154420, AC154433, AC154795, CT010582, CT025624

UniProtKB/TrEMBL

C3VLD3

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
NM_001253359.1 → NP_001240288.1 calcium-activated potassium channel subunit alpha-1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an alternate splice site in the 3' coding region, which does not affect the reading frame, compared to variant 1. The resulting isoform (2) lacks an internal single aa, compared to isoform 1.

Source sequence(s)

AC154420, AC154433, AC154795, CT010582, CT025624

UniProtKB/TrEMBL

C3VLD3

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
NM_001253360.1 → NP_001240289.1 calcium-activated potassium channel subunit alpha-1 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an in-frame exon and has an alternate splice site in the 3' coding region, which does not affect the reading frame, compared to variant 1. The resulting isoform (3) lacks an internal segment and an internal single aa, compared to isoform 1.

Source sequence(s)

AC154420, AC154433, AC154795, CT010582, CT025624

UniProtKB/TrEMBL

A0A087WSJ2, E3VRY9

Related

ENSMUSP00000141069.3, ENSMUST00000188210.8

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
NM_001253361.1 → NP_001240290.1 calcium-activated potassium channel subunit alpha-1 isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) has multiple differences in the coding region, one of which results in a frameshift, compared to variant 1. The resulting isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC154420, AC154433, AC154795, CT010582, CT025624

UniProtKB/TrEMBL

A0A286YCZ9

Related

ENSMUSP00000153214.2, ENSMUST00000224077.2

Conserved Domains (4) summary

pfam00520
Location:210 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

pfam07885
Location:306 → 391

Ion_trans_2; Ion channel

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
NM_001253362.1 → NP_001240291.1 calcium-activated potassium channel subunit alpha-1 isoform 5

Status: VALIDATED

Description

Transcript Variant: This variant (5) has multiple differences in the coding region, one of which results in a frameshift, compared to variant 1. The resulting isoform (5) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC154420, AC154433, AC154795, CT010582, CT025624

UniProtKB/TrEMBL

A0A286YDC1

Related

ENSMUSP00000153362.2, ENSMUST00000223655.2

Conserved Domains (4) summary

pfam00520
Location:210 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

pfam07885
Location:306 → 391

Ion_trans_2; Ion channel

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
NM_001253363.1 → NP_001240292.1 calcium-activated potassium channel subunit alpha-1 isoform 6

Status: VALIDATED

Description

Transcript Variant: This variant (6) has multiple differences in the coding region, one of which results in a frameshift, compared to variant 1. The resulting isoform (6) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AK135652, BC065068

Consensus CDS

CCDS79278.1

UniProtKB/TrEMBL

A0A087WQN5, A0A286YCW3

Related

ENSMUSP00000140275.2, ENSMUST00000188285.7

Conserved Domains (4) summary

pfam00520
Location:210 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

pfam07885
Location:306 → 391

Ion_trans_2; Ion channel

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
NM_001253364.1 → NP_001240293.1 calcium-activated potassium channel subunit alpha-1 isoform 7

Status: VALIDATED

Description

Transcript Variant: This variant (7) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting isoform (7) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC154420, AC154433, AC154795, CT010582, CT025624

UniProtKB/TrEMBL

A0A286YD59

Related

ENSMUSP00000153291.2, ENSMUST00000224232.2

Conserved Domains (4) summary

pfam00520
Location:210 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

pfam07885
Location:306 → 391

Ion_trans_2; Ion channel

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
NM_001253365.1 → NP_001240294.1 calcium-activated potassium channel subunit alpha-1 isoform 9

Status: VALIDATED

Description

Transcript Variant: This variant (9) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (9) lacks an internal segment, compared to isoform 1.

Source sequence(s)

AK135652, BC065068, L16912

UniProtKB/TrEMBL

E3VRY8

Related

ENSMUSP00000153078.2, ENSMUST00000224025.2

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
NM_001253366.1 → NP_001240295.1 calcium-activated potassium channel subunit alpha-1 isoform 10

Status: VALIDATED

Description

Transcript Variant: This variant (10) lacks an in-frame exon and has an alternate splice site in the 3' coding region, which does not affect the reading frame, compared to variant 1. The resulting isoform (10) lacks an internal segment and an internal single aa, compared to isoform 1.

Source sequence(s)

AC154420, AC154433, AC154795, CT010582, CT025624

UniProtKB/TrEMBL

E3VRY8

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
NM_001253367.1 → NP_001240296.1 calcium-activated potassium channel subunit alpha-1 isoform 11

Status: VALIDATED

Description

Transcript Variant: This variant (11) lacks an in-frame exon and has an alternate splice site in the 3' coding region, which does not affect the reading frame, compared to variant 1. The resulting isoform (11) lacks an internal segment and an internal single aa, compared to isoform 1.

Source sequence(s)

AC154420, AC154433, AC154795, CT010582, CT025624

UniProtKB/TrEMBL

A0A286YE30

Related

ENSMUSP00000153670.2, ENSMUST00000225431.2

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
NM_001253368.1 → NP_001240297.1 calcium-activated potassium channel subunit alpha-1 isoform 12

Status: VALIDATED

Description

Transcript Variant: This variant (12) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting isoform (12) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC154420, AC154433, AC154795, CT010582, CT025624

UniProtKB/TrEMBL

A0A286YDR7

Related

ENSMUSP00000153527.2, ENSMUST00000224812.2

Conserved Domains (4) summary

pfam00520
Location:210 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

pfam07885
Location:306 → 391

Ion_trans_2; Ion channel

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
NM_001253369.1 → NP_001240298.1 calcium-activated potassium channel subunit alpha-1 isoform 13

Status: VALIDATED

Description

Transcript Variant: This variant (13) has multiple differences in the coding region, one of which results in a frameshift, compared to variant 1. The resulting isoform (13) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AK135652, BC065068, U09383

Consensus CDS

CCDS79277.1

UniProtKB/Swiss-Prot

Q08460, Q64703, Q8VHF1, Q9R196

UniProtKB/TrEMBL

A0A286YD35

Related

ENSMUSP00000153247.2, ENSMUST00000145596.3

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
NM_001253370.1 → NP_001240299.1 calcium-activated potassium channel subunit alpha-1 isoform 14

Status: VALIDATED

Description

Transcript Variant: This variant (14) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting isoform (14) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC154420, AC154433, AC154795, CT010582, CT025624

UniProtKB/TrEMBL

A0A286YCQ2

Related

ENSMUSP00000153083.2, ENSMUST00000225471.2

Conserved Domains (2) summary

PLN03192
Location:217 → 393

PLN03192; Voltage-dependent potassium channel; Provisional

PRK10537
Location:343 → 415

PRK10537; voltage-gated potassium channel protein
NM_001253371.1 → NP_001240300.1 calcium-activated potassium channel subunit alpha-1 isoform 15

Status: VALIDATED

Description

Transcript Variant: This variant (15) lacks an exon and has an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The resulting isoform (15) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC154420, AC154433, AC154795, CT010582, CT025624

UniProtKB/TrEMBL

E3VRY4

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
NM_001253372.1 → NP_001240301.1 calcium-activated potassium channel subunit alpha-1 isoform 16

Status: VALIDATED

Description

Transcript Variant: This variant (16) has multiple differences in the coding region, one of which results in a frameshift, compared to variant 1. The resulting isoform (16) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC154420, AC154433, AC154795, CT010582, CT025624

UniProtKB/Swiss-Prot

Q08460, Q64703, Q8VHF1, Q9R196

Related

ENSMUSP00000153584.2, ENSMUST00000225315.2

Conserved Domains (4) summary

pfam00520
Location:210 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

pfam07885
Location:306 → 391

Ion_trans_2; Ion channel

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
NM_001253373.1 → NP_001240302.1 calcium-activated potassium channel subunit alpha-1 isoform 17

Status: VALIDATED

Description

Transcript Variant: This variant (17) has multiple differences in the coding region, one of which results in a frameshift, compared to variant 1. The resulting isoform (17) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC154420, AC154433, AC154795, CT010582, CT025624

UniProtKB/TrEMBL

A0A286YCF5

Related

ENSMUSP00000152959.2, ENSMUST00000225556.2

Conserved Domains (4) summary

pfam00520
Location:210 → 396

Ion_trans; Ion transport protein

pfam03493
Location:532 → 581

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

pfam07885
Location:306 → 391

Ion_trans_2; Ion channel

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
NM_001253374.1 → NP_001240303.1 calcium-activated potassium channel subunit alpha-1 isoform 18

Status: VALIDATED

Description

Transcript Variant: This variant (18) lacks two in-frame exons in the coding region, compared to variant 1. The resulting isoform (18) lacks two internal segments, compared to isoform 1.

Source sequence(s)

AC154420, AC154433, AC154795, CT010582, CT025624

UniProtKB/TrEMBL

A0A286YCI9

Related

ENSMUSP00000152999.2, ENSMUST00000224787.2

Conserved Domains (3) summary

pfam00520
Location:128 → 342

Ion_trans; Ion transport protein

pfam03493
Location:491 → 579

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:356 → 469

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
NM_001253375.1 → NP_001240304.1 calcium-activated potassium channel subunit alpha-1 isoform 19

Status: VALIDATED

Description

Transcript Variant: This variant (19) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting isoform (19) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC154420, AC154433, AC154795, CT010582, CT025624

UniProtKB/TrEMBL

E3VRY6

Related

ENSMUSP00000153316.2, ENSMUST00000224285.2

Conserved Domains (3) summary

pfam00520
Location:179 → 387

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
NM_001253376.1 → NP_001240305.1 calcium-activated potassium channel subunit alpha-1 isoform 20

Status: VALIDATED

Description

Transcript Variant: This variant (20) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting isoform (20) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC154420, AC154433, AC154795, CT010582, CT025624

UniProtKB/TrEMBL

E3VRZ4

Related

ENSMUSP00000153216.2, ENSMUST00000223749.2

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
NM_001253377.1 → NP_001240306.1 calcium-activated potassium channel subunit alpha-1 isoform 21

Status: VALIDATED

Description

Transcript Variant: This variant (21) lacks three coding exons, one of which results in a frameshift, compared to variant 1. The resulting isoform (21) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC154420, AC154433, AC154795, CT010582, CT025624

Consensus CDS

CCDS79275.1

UniProtKB/Swiss-Prot

Q08460, Q64703, Q8VHF1, Q9R196

UniProtKB/TrEMBL

A0A087WQ41

Related

ENSMUSP00000140033.2, ENSMUST00000190044.7

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:538 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:446 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
NM_001253378.1 → NP_001240307.1 calcium-activated potassium channel subunit alpha-1 isoform 22

Status: VALIDATED

Description

Transcript Variant: This variant (22) lacks three coding exons and has an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The resulting isoform (22) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC154420, AC154433, AC154795, CT010582, CT025624

UniProtKB/TrEMBL

A0A286YCW3

Related

ENSMUSP00000153158.2, ENSMUST00000223727.2

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
NM_010610.3 → NP_034740.2 calcium-activated potassium channel subunit alpha-1 isoform 8

Status: VALIDATED

Description

Transcript Variant: This variant (8) has multiple differences in the coding region, one of which results in a frameshift, compared to variant 1. The resulting isoform (8) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AF156674, AK135652, BC065068

Consensus CDS

CCDS79276.1

UniProtKB/TrEMBL

A0A087WRS4, A0A286YDC1

Related

ENSMUSP00000140751.2, ENSMUST00000188991.7

Conserved Domains (4) summary

pfam00520
Location:210 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

pfam07885
Location:306 → 391

Ion_trans_2; Ion channel

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

23342356..24055173 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017315875.3 → XP_017171364.1 calcium-activated potassium channel subunit alpha-1 isoform X18

UniProtKB/TrEMBL

A0A286YE30

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_017315873.3 → XP_017171362.1 calcium-activated potassium channel subunit alpha-1 isoform X13

UniProtKB/TrEMBL

A0A087WSJ2, E3VRY9

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_006518594.5 → XP_006518657.1 calcium-activated potassium channel subunit alpha-1 isoform X4

UniProtKB/TrEMBL

C3VLD3

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_036158482.1 → XP_036014375.1 calcium-activated potassium channel subunit alpha-1 isoform X17

UniProtKB/TrEMBL

A0A286YE30

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:538 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:446 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_036158481.1 → XP_036014374.1 calcium-activated potassium channel subunit alpha-1 isoform X12

UniProtKB/TrEMBL

A0A087WSJ2, E3VRY9

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:538 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:446 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_017315872.3 → XP_017171361.1 calcium-activated potassium channel subunit alpha-1 isoform X11

UniProtKB/TrEMBL

A0A087WSJ2, E3VRY9

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_006518599.5 → XP_006518662.1 calcium-activated potassium channel subunit alpha-1 isoform X7

UniProtKB/TrEMBL

A0A087WSJ2, C3VLD3, E3VRY9

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_006518593.5 → XP_006518656.1 calcium-activated potassium channel subunit alpha-1 isoform X3

UniProtKB/TrEMBL

C3VLD3

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_017315874.3 → XP_017171363.1 calcium-activated potassium channel subunit alpha-1 isoform X16

UniProtKB/TrEMBL

E3VRY8, E3VRZ1

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_006518606.5 → XP_006518669.1 calcium-activated potassium channel subunit alpha-1 isoform X15

UniProtKB/TrEMBL

E3VRY8

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_011244967.4 → XP_011243269.1 calcium-activated potassium channel subunit alpha-1 isoform X10

UniProtKB/TrEMBL

C3VLD3

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_017315870.3 → XP_017171359.1 calcium-activated potassium channel subunit alpha-1 isoform X6

UniProtKB/TrEMBL

E3VRY8

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_006518595.5 → XP_006518658.1 calcium-activated potassium channel subunit alpha-1 isoform X5

UniProtKB/TrEMBL

E3VRY8

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_006518592.5 → XP_006518655.1 calcium-activated potassium channel subunit alpha-1 isoform X2

UniProtKB/TrEMBL

C3VLD3

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_006518591.5 → XP_006518654.1 calcium-activated potassium channel subunit alpha-1 isoform X1

UniProtKB/TrEMBL

C3VLD3

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_017315880.3 → XP_017171369.1 calcium-activated potassium channel subunit alpha-1 isoform X22

UniProtKB/TrEMBL

A0A286YCW3

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_017315883.3 → XP_017171372.1 calcium-activated potassium channel subunit alpha-1 isoform X25

UniProtKB/TrEMBL

A0A286YCW3

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_017315878.3 → XP_017171367.1 calcium-activated potassium channel subunit alpha-1 isoform X21

UniProtKB/TrEMBL

E3VRY4

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_006518605.5 → XP_006518668.1 calcium-activated potassium channel subunit alpha-1 isoform X14

UniProtKB/TrEMBL

A0A286YCW3, A0A286YDM6

Related

ENSMUSP00000153312.2, ENSMUST00000224468.2

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_006518603.5 → XP_006518666.1 calcium-activated potassium channel subunit alpha-1 isoform X9

UniProtKB/TrEMBL

E3VRY4

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_017315881.3 → XP_017171370.1 calcium-activated potassium channel subunit alpha-1 isoform X23

UniProtKB/Swiss-Prot

Q08460, Q64703, Q8VHF1, Q9R196

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_006518610.5 → XP_006518673.1 calcium-activated potassium channel subunit alpha-1 isoform X24

UniProtKB/Swiss-Prot

Q08460, Q64703, Q8VHF1, Q9R196

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_036158483.1 → XP_036014376.1 calcium-activated potassium channel subunit alpha-1 isoform X20

UniProtKB/Swiss-Prot

Q08460, Q64703, Q8VHF1, Q9R196

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:538 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:446 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_017315876.3 → XP_017171365.1 calcium-activated potassium channel subunit alpha-1 isoform X19

UniProtKB/Swiss-Prot

Q08460, Q64703, Q8VHF1, Q9R196

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_006518602.5 → XP_006518665.1 calcium-activated potassium channel subunit alpha-1 isoform X8

UniProtKB/Swiss-Prot

Q08460, Q64703, Q8VHF1, Q9R196

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:545 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:410 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_036158484.1 → XP_036014377.1 calcium-activated potassium channel subunit alpha-1 isoform X26