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    Rhot1 ras homolog family member T1 [ Mus musculus (house mouse) ]

    Gene ID: 59040, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Rhot1provided by MGI
    Official Full Name
    ras homolog family member T1provided by MGI
    Primary source
    MGI:MGI:1926078
    See related
    Ensembl:ENSMUSG00000017686 AllianceGenome:MGI:1926078
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Arht1; Miro1; 2210403N23Rik; C430039G08Rik
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in several processes, including mitochondrial outer membrane permeabilization; mitochondrion transport along microtubule; and regulation of mitochondrion organization. Located in mitochondrion. Is expressed in brain. Used to study motor neuron disease. Orthologous to human RHOT1 (ras homolog family member T1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 10.8), bladder adult (RPKM 10.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 B5; 11 47.62 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (80099844..80158736)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (80208610..80267907)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ArfGAP with dual PH domains 2, opposite strand Neighboring gene ArfGAP with dual PH domains 2 Neighboring gene STARR-seq mESC enhancer starr_30143 Neighboring gene STARR-positive B cell enhancer ABC_E7025 Neighboring gene ring finger protein 135 Neighboring gene STARR-seq mESC enhancer starr_30145 Neighboring gene STARR-positive B cell enhancer mm9_chr11:80116169-80116470 Neighboring gene rhomboid like 3 Neighboring gene RIKEN cDNA 5730455P16 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Miro1 regulates mitochondrial homeostasis and meiotic resumption of mouse oocyte. Xue Y, et al. J Cell Physiol, 2022 Dec. PMID 36183380
    2. Steady-State Levels of Miro1 Linked to Phosphorylation at Serine 156 and Mitochondrial Respiration in Dopaminergic Neurons. Schwarz L, et al. Cells, 2022 Apr 8. PMID 35455950, Free PMC Article
    3. Mitochondrial transfer from mesenchymal stem cells improves neuronal metabolism after oxidant injury in vitro: The role of Miro1. Tseng N, et al. J Cereb Blood Flow Metab, 2021 Apr. PMID 32501156, Free PMC Article
    4. A role for Mitochondrial Rho GTPase 1 (MIRO1) in motility and membrane dynamics of peroxisomes. Castro IG, et al. Traffic, 2018 Mar. PMID 29364559, Free PMC Article
    5. Miro1-mediated mitochondrial positioning shapes intracellular energy gradients required for cell migration. Schuler MH, et al. Mol Biol Cell, 2017 Aug 1. PMID 28615318, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lipotoxicity-polarised macrophage-derived exosomes regulate mitochondrial fitness through Miro1-mediated mitophagy inhibition and contribute to type 2 diabetes development in mice.
      Title: Lipotoxicity-polarised macrophage-derived exosomes regulate mitochondrial fitness through Miro1-mediated mitophagy inhibition and contribute to type 2 diabetes development in mice.
    2. Miro1 regulates mitochondrial homeostasis and meiotic resumption of mouse oocyte.
      Title: Miro1 regulates mitochondrial homeostasis and meiotic resumption of mouse oocyte.
    3. A Protumorigenic mDia2-MIRO1 Axis Controls Mitochondrial Positioning and Function in Cancer-Associated Fibroblasts.
      Title: A Protumorigenic mDia2-MIRO1 Axis Controls Mitochondrial Positioning and Function in Cancer-Associated Fibroblasts.
    4. Steady-State Levels of Miro1 Linked to Phosphorylation at Serine 156 and Mitochondrial Respiration in Dopaminergic Neurons.
      Title: Steady-State Levels of Miro1 Linked to Phosphorylation at Serine 156 and Mitochondrial Respiration in Dopaminergic Neurons.
    5. Loss of neuronal Miro1 disrupts mitophagy and induces hyperactivation of the integrated stress response.
      Title: Loss of neuronal Miro1 disrupts mitophagy and induces hyperactivation of the integrated stress response.
    6. Mitochondrial transfer from mesenchymal stem cells improves neuronal metabolism after oxidant injury in vitro: The role of Miro1.
      Title: Mitochondrial transfer from mesenchymal stem cells improves neuronal metabolism after oxidant injury in vitro: The role of Miro1.
    7. Amyloid-beta oligomers induce Parkin-mediated mitophagy by reducing Miro1.
      Title: Amyloid-beta oligomers induce Parkin-mediated mitophagy by reducing Miro1.
    8. The data point to HDAC6-dependent deacetylation of Miro1 as a mediator of axon growth inhibition through decreased mitochondrial transport.
      Title: Deacetylation of Miro1 by HDAC6 blocks mitochondrial transport and mediates axon growth inhibition.
    9. Using knockout mouse embryonic fibroblasts, data show that mitochondrial Rho (Miro) GTPases Miro1 and Miro2 are required for normal mitochondrial cristae architecture and endoplasmic reticulum-mitochondria contacts Sites (ERMCS).
      Title: Miro clusters regulate ER-mitochondria contact sites and link cristae organization to the mitochondrial transport machinery.
    10. coupling between MCU and Miro1 as a novel mechanism modulating both mitochondrial Ca(2+) uptake and mitochondrial transport
      Title: MCU Interacts with Miro1 to Modulate Mitochondrial Functions in Neurons.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (6)  1 citation
    • Endonuclease-mediated (4) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ11040

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of mitochondrion localization by microtubule attachment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial outer membrane permeabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrion transport along microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrion transport along microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neurotransmitter secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of organelle transport along microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    mitochondrial Rho GTPase 1
    Names
    ras homolog gene family, member T1
    NP_001156826.1
    NP_001156827.1
    NP_001349797.1
    NP_001349798.1
    NP_001349799.1
    NP_001391057.1
    NP_001391058.1
    NP_067511.4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163354.2 → NP_001156826.1  mitochondrial Rho GTPase 1 isoform 2

      See identical proteins and their annotated locations for NP_001156826.1

      Status: VALIDATED

      Source sequence(s)
      AK147801, AL591426
      Consensus CDS
      CCDS48861.1
      UniProtKB/Swiss-Prot
      Q8BG51
      Related
      ENSMUSP00000017831.9, ENSMUST00000017831.16
      Conserved Domains (5) summary
      smart00174
      Location:20 → 182
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
      cd01892
      Location:428 → 593
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      cd01893
      Location:16 → 182
      Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
      pfam08355
      Location:354 → 422
      EF_assoc_1; EF hand associated
      pfam08356
      Location:234 → 314
      EF_assoc_2; EF hand associated

    2. NM_001163355.2 → NP_001156827.1  mitochondrial Rho GTPase 1 isoform 3

      See identical proteins and their annotated locations for NP_001156827.1

      Status: VALIDATED

      Source sequence(s)
      AK147801, AK167502, AL591426
      Consensus CDS
      CCDS48862.1
      UniProtKB/Swiss-Prot
      Q8BG51
      Related
      ENSMUSP00000057669.10, ENSMUST00000055056.16
      Conserved Domains (5) summary
      smart00174
      Location:20 → 182
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
      cd01892
      Location:428 → 594
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      cd01893
      Location:16 → 182
      Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
      pfam08355
      Location:354 → 422
      EF_assoc_1; EF hand associated
      pfam08356
      Location:234 → 314
      EF_assoc_2; EF hand associated

    3. NM_001362868.1 → NP_001349797.1  mitochondrial Rho GTPase 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL591426
      Consensus CDS
      CCDS88206.1
      Related
      ENSMUSP00000076664.8, ENSMUST00000077451.14
      Conserved Domains (4) summary
      cd01892
      Location:428 → 593
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      cd01893
      Location:16 → 182
      Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
      pfam08355
      Location:354 → 422
      EF_assoc_1; EF hand associated
      pfam08356
      Location:232 → 316
      EF_assoc_2; EF hand associated

    4. NM_001362869.1 → NP_001349798.1  mitochondrial Rho GTPase 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL591426
      Conserved Domains (4) summary
      cd01892
      Location:341 → 506
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      pfam08355
      Location:267 → 335
      EF_assoc_1; EF hand associated
      pfam08356
      Location:145 → 229
      EF_assoc_2; EF hand associated
      cl21455
      Location:36 → 95
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    5. NM_001362870.1 → NP_001349799.1  mitochondrial Rho GTPase 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL591426
      UniProtKB/TrEMBL
      F7ASU3
      Related
      ENSMUSP00000117941.2, ENSMUST00000134894.2
      Conserved Domains (4) summary
      cd01892
      Location:288 → 454
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      pfam08355
      Location:214 → 282
      EF_assoc_1; EF hand associated
      pfam08356
      Location:92 → 176
      EF_assoc_2; EF hand associated
      cl21455
      Location:1 → 42
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    6. NM_001404128.1 → NP_001391057.1  mitochondrial Rho GTPase 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL591426

    7. NM_001404129.1 → NP_001391058.1  mitochondrial Rho GTPase 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL591426

    8. NM_021536.8 → NP_067511.4  mitochondrial Rho GTPase 1 isoform 1

      See identical proteins and their annotated locations for NP_067511.4

      Status: VALIDATED

      Source sequence(s)
      AK054472, AK147801, AL591426
      Consensus CDS
      CCDS25130.1
      UniProtKB/Swiss-Prot
      Q3TJB7, Q3UGU4, Q5SYC3, Q5SYC6, Q8BG51, Q8BLW3, Q8BMH1, Q922N0, Q9D2R1, Q9JKB9
      Related
      ENSMUSP00000090533.7, ENSMUST00000092857.13
      Conserved Domains (5) summary
      smart00174
      Location:20 → 182
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
      cd01892
      Location:428 → 605
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      cd01893
      Location:16 → 182
      Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
      pfam08355
      Location:354 → 422
      EF_assoc_1; EF hand associated
      pfam08356
      Location:234 → 314
      EF_assoc_2; EF hand associated

    RNA

    1. NR_175822.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL591426

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      80099844..80158736
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_879726.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BG51.1 GenPept UniProtKB/Swiss-Prot:Q8BG51

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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