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    Ak4 adenylate kinase 4 [ Mus musculus (house mouse) ]

    Gene ID: 11639, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ak4provided by MGI
    Official Full Name
    adenylate kinase 4provided by MGI
    Primary source
    MGI:MGI:87979
    See related
    Ensembl:ENSMUSG00000028527 AllianceGenome:MGI:87979
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ak3; AK 4; Ak-3; Ak-4; Ak3l1; D4Ertd274e
    Summary
    Predicted to enable nucleoside diphosphate kinase activity. Predicted to be involved in several processes, including nucleoside phosphate metabolic process; regulation of ATP biosynthetic process; and regulation of oxidative phosphorylation. Predicted to act upstream of or within phosphorylation. Located in mitochondrial matrix. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human AK4 (adenylate kinase 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in kidney adult (RPKM 34.8), cerebellum adult (RPKM 9.7) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ak4 in Genome Data Viewer
    Location:
    4 C6; 4 46.84 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (101273675..101324968)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (101416478..101467771)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA E130102H24 gene Neighboring gene RIKEN cDNA 0610043K17 gene Neighboring gene microRNA 101a Neighboring gene ribosomal protein L9 pseudogene Neighboring gene STARR-seq mESC enhancer starr_10903 Neighboring gene STARR-seq mESC enhancer starr_10910 Neighboring gene STARR-seq mESC enhancer starr_10915 Neighboring gene DnaJ heat shock protein family (Hsp40) member C6 Neighboring gene predicted gene, 36012 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:101319917-101320026 Neighboring gene STARR-positive B cell enhancer ABC_E2698 Neighboring gene leptin receptor overlapping transcript

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Adenylate Kinase 4 Promotes Inflammatory Gene Expression via Hif1α and AMPK in Macrophages. Chin WY, et al. Front Immunol, 2021. PMID 33790902, Free PMC Article
    2. Identification of a novel adenylate kinase system in the brain: cloning of the fourth adenylate kinase. Yoneda T, et al. Brain Res Mol Brain Res, 1998 Nov 20. PMID 9813319
    3. Structure and expression of human mitochondrial adenylate kinase targeted to the mitochondrial matrix. Noma T, et al. Biochem J, 2001 Aug 15. PMID 11485571, Free PMC Article
    4. Scrambler and yotari disrupt the disabled gene and produce a reeler-like phenotype in mice. Sheldon M, et al. Nature, 1997 Oct 16. PMID 9338784
    5. The gene encoding disabled-1 (DAB1), the intracellular adaptor of the Reelin pathway, reveals unusual complexity in human and mouse. Bar I, et al. J Biol Chem, 2003 Feb 21. PMID 12446734

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Adenylate Kinase 4 Promotes Inflammatory Gene Expression via Hif1alpha and AMPK in Macrophages.
      Title: Adenylate Kinase 4 Promotes Inflammatory Gene Expression via Hif1α and AMPK in Macrophages.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleobase-containing compound kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleoside diphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleoside diphosphate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleoside triphosphate adenylate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotransferase activity, phosphate group as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in AMP metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in AMP metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ATP metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in GTP metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleobase-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleoside triphosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of oxidative phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribonucleoside diphosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    adenylate kinase 4, mitochondrial
    Names
    ATP-AMP transphosphorylase
    GTP:AMP phosphotransferase AK4, mitochondrial
    adenylate kinase 3 alpha-like 1
    adenylate kinase 3-like 1
    adenylate kinase isoenzyme 4, mitochondrial
    NP_001171073.1
    NP_001171075.1
    NP_001171076.1
    NP_033777.1
    XP_006502748.1
    XP_017175412.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177602.1 → NP_001171073.1  adenylate kinase 4, mitochondrial

      See identical proteins and their annotated locations for NP_001171073.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 encode the same protein.
      Source sequence(s)
      AK004491, AL845364, AV023306, BC086663, BY718404
      Consensus CDS
      CCDS18394.1
      UniProtKB/Swiss-Prot
      Q9R1X7, Q9WUR9
      UniProtKB/TrEMBL
      Q3U489
      Related
      ENSMUSP00000102559.2, ENSMUST00000106946.8
      Conserved Domains (1) summary
      TIGR01351
      Location:7 → 211
      adk; adenylate kinase

    2. NM_001177604.1 → NP_001171075.1  adenylate kinase 4, mitochondrial

      See identical proteins and their annotated locations for NP_001171075.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      AK004491, AL845364, AV023306, BC086663, BY203078
      Consensus CDS
      CCDS18394.1
      UniProtKB/Swiss-Prot
      Q9R1X7, Q9WUR9
      UniProtKB/TrEMBL
      Q3U489
      Related
      ENSMUSP00000102558.2, ENSMUST00000106945.8
      Conserved Domains (1) summary
      TIGR01351
      Location:7 → 211
      adk; adenylate kinase

    3. NM_001177605.1 → NP_001171076.1  adenylate kinase 4, mitochondrial

      See identical proteins and their annotated locations for NP_001171076.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      AK004491, AL845364, AV023306, BC086663, BY740484
      Consensus CDS
      CCDS18394.1
      UniProtKB/Swiss-Prot
      Q9R1X7, Q9WUR9
      UniProtKB/TrEMBL
      Q3U489
      Related
      ENSMUSP00000099841.2, ENSMUST00000102780.8
      Conserved Domains (1) summary
      TIGR01351
      Location:7 → 211
      adk; adenylate kinase

    4. NM_009647.5 → NP_033777.1  adenylate kinase 4, mitochondrial

      See identical proteins and their annotated locations for NP_033777.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      AK004491, AL845364, AV023306, BC086663, CJ087385
      Consensus CDS
      CCDS18394.1
      UniProtKB/Swiss-Prot
      Q9R1X7, Q9WUR9
      UniProtKB/TrEMBL
      Q3U489
      Conserved Domains (1) summary
      TIGR01351
      Location:7 → 211
      adk; adenylate kinase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      101273675..101324968
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319923.2 → XP_017175412.1  adenylate kinase 4, mitochondrial isoform X1

      Conserved Domains (1) summary
      TIGR01351
      Location:7 → 171
      adk; adenylate kinase

    2. XM_006502685.3 → XP_006502748.1  adenylate kinase 4, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_006502748.1

      UniProtKB/TrEMBL
      F6TEU8
      Related
      ENSMUSP00000121112.2, ENSMUST00000155749.2
      Conserved Domains (1) summary
      TIGR01351
      Location:1 → 139
      adk; adenylate kinase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WUR9.1 GenPept UniProtKB/Swiss-Prot:Q9WUR9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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