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    Btbd1 BTB domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 83962, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Btbd1provided by MGI
    Official Full Name
    BTB domain containing 1provided by MGI
    Primary source
    MGI:MGI:1933765
    See related
    Ensembl:ENSMUSG00000025103 AllianceGenome:MGI:1933765
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1190005H08Rik
    Summary
    Predicted to enable cullin family protein binding activity and identical protein binding activity. Predicted to be involved in neurogenesis. Predicted to act upstream of or within cell differentiation and muscle organ development. Located in P-body. Is expressed in several structures, including alimentary system; eye; immune system; liver and biliary system; and reproductive system. Orthologous to human BTBD1 (BTB domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 45.4), ovary adult (RPKM 21.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 D3; 7 45.71 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (81441822..81479262, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (81792074..81829498, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6568 Neighboring gene RIKEN cDNA 3110040N11 gene Neighboring gene RNA guanine-7 methyltransferase activating subunit Neighboring gene STARR-positive B cell enhancer ABC_E4944 Neighboring gene STARR-seq mESC enhancer starr_19371 Neighboring gene predicted gene, 32695 Neighboring gene predicted gene, 51491 Neighboring gene STARR-seq mESC enhancer starr_19372 Neighboring gene transmembrane 6 superfamily member 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:89025770-89025983 Neighboring gene HDGF like 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Involvement of BTBD1 in mesenchymal differentiation. Pisani DF, et al. Exp Cell Res, 2007 Jul 1. PMID 17462629
    2. The topoisomerase 1-interacting protein BTBD1 is essential for muscle cell differentiation. Pisani DF, et al. Cell Death Differ, 2004 Nov. PMID 15486563
    3. Identification and characterization of BTBD1, a novel BTB domain containing gene on human chromosome 15q24. Carim-Todd L, et al. Gene, 2001 Jan 10. PMID 11179693
    4. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. Xu L, et al. Exp Cell Res, 2003 Aug 1. PMID 12878161
    5. Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks. Xu G, et al. Mol Cell Proteomics, 2014 Feb. PMID 24319055, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MiR-200b-5p inhibits tumor progression in salivary adenoid cystic carcinoma via targeting BTBD1.
      Title: MiR-200b-5p inhibits tumor progression in salivary adenoid cystic carcinoma via targeting BTBD1.
    2. BTBD1 is a key protein of balance between adipogenesis and myogenesis.
      Title: Involvement of BTBD1 in mesenchymal differentiation.
    3. BTBD1 is essential for myogenic differentiation
      Title: The topoisomerase 1-interacting protein BTBD1 is essential for muscle cell differentiation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC37676

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cullin family protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within muscle organ development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in P-body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    BTB/POZ domain-containing protein 1
    Names
    BTB (POZ) domain containing 1
    glucose signal-repressing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_146193.2 → NP_666305.2  BTB/POZ domain-containing protein 1

      See identical proteins and their annotated locations for NP_666305.2

      Status: PROVISIONAL

      Source sequence(s)
      BC072618
      Consensus CDS
      CCDS21407.1
      UniProtKB/Swiss-Prot
      P58544, Q6GQU7, Q8BTZ0, Q8K0J0
      UniProtKB/TrEMBL
      Q5M8N6
      Related
      ENSMUSP00000026093.8, ENSMUST00000026093.9
      Conserved Domains (4) summary
      smart00225
      Location:94 → 181
      BTB; Broad-Complex, Tramtrack and Bric a brac
      smart00875
      Location:193 → 292
      BACK; BTB And C-terminal Kelch
      pfam00651
      Location:68 → 177
      BTB; BTB/POZ domain
      pfam08005
      Location:340 → 486
      PHR; PHR domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      81441822..81479262 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006541322.5 → XP_006541385.1  BTB/POZ domain-containing protein 1 isoform X1

      Conserved Domains (3) summary
      cd18346
      Location:53 → 185
      BTB_POZ_BTBD1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1)
      pfam08005
      Location:340 → 358
      PHR; PHR domain
      cl28903
      Location:181 → 287
      BACK; BACK (BTB and C-terminal Kelch) domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P58544.3 GenPept UniProtKB/Swiss-Prot:P58544

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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