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    Tm9sf2 transmembrane 9 superfamily member 2 [ Mus musculus (house mouse) ]

    Gene ID: 68059, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Tm9sf2provided by MGI
    Official Full Name
    transmembrane 9 superfamily member 2provided by MGI
    Primary source
    MGI:MGI:1915309
    See related
    Ensembl:ENSMUSG00000025544 AllianceGenome:MGI:1915309
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P76; D14Ertd64e; 1500001N15Rik
    Summary
    Predicted to be involved in protein localization to membrane. Predicted to be located in Golgi apparatus; cytoskeleton; and endosome. Predicted to be integral component of membrane. Predicted to be active in membrane. Is expressed in several structures, including cerebral cortex subventricular zone; cranium; liver lobe; otic capsule; and thoracic segment skeleton. Orthologous to human TM9SF2 (transmembrane 9 superfamily member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in colon adult (RPKM 91.0), duodenum adult (RPKM 80.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    14 E5; 14 65.86 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (122342290..122397015)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (122107082..122159603)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene ubiquitin associated domain containing 2 Neighboring gene STARR-positive B cell enhancer mm9_chr14:122364300-122364601 Neighboring gene G protein-coupled receptor 183 Neighboring gene STARR-positive B cell enhancer ABC_E8580 Neighboring gene STARR-positive B cell enhancer ABC_E4126 Neighboring gene STARR-positive B cell enhancer ABC_E4127 Neighboring gene STARR-positive B cell enhancer ABC_E8581 Neighboring gene predicted gene, 52103 Neighboring gene translocase of inner mitochondrial membrane 8A2 Neighboring gene STARR-positive B cell enhancer ABC_E5466 Neighboring gene RIKEN cDNA A330035P11 gene Neighboring gene STARR-positive B cell enhancer ABC_E5467 Neighboring gene STARR-seq mESC enhancer starr_37749 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene RIKEN cDNA 1700108J01 gene Neighboring gene citrate lyase beta like Neighboring gene STARR-seq mESC enhancer starr_37753 Neighboring gene STARR-seq mESC enhancer starr_37767 Neighboring gene predicted gene 5089 Neighboring gene predicted gene, 25464

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of 2 novel genes developmentally regulated in the mouse aorta-gonad-mesonephros region. Orelio C, et al. Blood, 2003 Mar 15. PMID 12433684
    2. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. Sansom SN, et al. PLoS Genet, 2009 Jun. PMID 19521500, Free PMC Article
    3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in ceramide metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycosphingolipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of heparan sulfate proteoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane 9 superfamily member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080556.3 → NP_542123.3  transmembrane 9 superfamily member 2 precursor

      See identical proteins and their annotated locations for NP_542123.3

      Status: VALIDATED

      Source sequence(s)
      AK048012, AV028818, BB619330
      Consensus CDS
      CCDS27345.1
      UniProtKB/Swiss-Prot
      P58021
      UniProtKB/TrEMBL
      Q542E4, Q8C6H4, Q8C7F9
      Related
      ENSMUSP00000026624.5, ENSMUST00000026624.11
      Conserved Domains (1) summary
      pfam02990
      Location:74 → 618
      EMP70; Endomembrane protein 70

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      122342290..122397015
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158835.1 → XP_036014728.1  transmembrane 9 superfamily member 2 isoform X1

      UniProtKB/Swiss-Prot
      P58021
      UniProtKB/TrEMBL
      Q542E4, Q8C6H4, Q8C7F9
      Conserved Domains (1) summary
      pfam02990
      Location:74 → 618
      EMP70; Endomembrane protein 70
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P58021.1 GenPept UniProtKB/Swiss-Prot:P58021

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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