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    Zdhhc1 zinc finger, DHHC domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 70796, updated on 9-May-2024

    Summary

    Official Symbol
    Zdhhc1provided by MGI
    Official Full Name
    zinc finger, DHHC domain containing 1provided by MGI
    Primary source
    MGI:MGI:1918046
    See related
    Ensembl:ENSMUSG00000039199 AllianceGenome:MGI:1918046
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DHHC-1; 4432412D04Rik
    Summary
    Enables protein-cysteine S-palmitoyltransferase activity. Involved in several processes, including antiviral innate immune response; peptidyl-L-cysteine S-palmitoylation; and positive regulation of defense response to virus by host. Acts upstream of or within protein palmitoylation. Located in endosome membrane. Is expressed in several structures, including adrenal gland; brain; genitourinary system; heart; and lung. Orthologous to human ZDHHC1 (zinc finger DHHC-type containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in lung adult (RPKM 28.6), ovary adult (RPKM 27.7) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    Location:
    8 D3; 8 53.04 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106199055..106223694, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105472419..105497062, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 36 Neighboring gene tubulin polymerization-promoting protein family member 3 Neighboring gene ferritin light chain 1 pseudogene Neighboring gene hydroxysteroid 11-beta dehydrogenase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables palmitoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables palmitoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-cysteine S-palmitoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    palmitoyltransferase ZDHHC1
    Names
    probable palmitoyltransferase ZDHHC1
    zinc finger DHHC domain-containing protein 1
    NP_001344181.1
    NP_001365935.1
    NP_001365936.1
    NP_001365937.1
    NP_001365938.1
    NP_001365939.1
    NP_001365940.1
    NP_780369.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357252.2NP_001344181.1  palmitoyltransferase ZDHHC1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2), as well as variant 5, encodes isoform 2.
      Source sequence(s)
      AC090480, AC151573
      UniProtKB/TrEMBL
      B7ZMY5
      Conserved Domains (1) summary
      pfam01529
      Location:126281
      DHHC; DHHC palmitoyltransferase
    2. NM_001379006.1NP_001365935.1  palmitoyltransferase ZDHHC1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variants 1 and 4, encodes isoform 1.
      Source sequence(s)
      AC090480, AC151573
      UniProtKB/Swiss-Prot
      Q0VE36, Q8BJ24, Q8R0N9
      Conserved Domains (1) summary
      pfam01529
      Location:126281
      DHHC; DHHC palmitoyltransferase
    3. NM_001379007.1NP_001365936.1  palmitoyltransferase ZDHHC1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), as well as variants 1 and 3, encodes isoform 1.
      Source sequence(s)
      AC090480, AC151573
      UniProtKB/Swiss-Prot
      Q0VE36, Q8BJ24, Q8R0N9
      Conserved Domains (1) summary
      pfam01529
      Location:126281
      DHHC; DHHC palmitoyltransferase
    4. NM_001379008.1NP_001365937.1  palmitoyltransferase ZDHHC1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variant 2, encodes isoform 2.
      Source sequence(s)
      AC090480, AC151573
      UniProtKB/TrEMBL
      B7ZMY5
      Conserved Domains (1) summary
      pfam01529
      Location:126281
      DHHC; DHHC palmitoyltransferase
    5. NM_001379009.1NP_001365938.1  palmitoyltransferase ZDHHC1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variants 7 and 8, encodes isoform 3.
      Source sequence(s)
      AC090480, AC151573
      Conserved Domains (1) summary
      pfam01529
      Location:126281
      DHHC; DHHC palmitoyltransferase
    6. NM_001379010.1NP_001365939.1  palmitoyltransferase ZDHHC1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variants 6 and 8, encodes isoform 3.
      Source sequence(s)
      AC090480, AC151573
      Conserved Domains (1) summary
      pfam01529
      Location:126281
      DHHC; DHHC palmitoyltransferase
    7. NM_001379011.1NP_001365940.1  palmitoyltransferase ZDHHC1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variants 6 and 7, encodes isoform 3.
      Source sequence(s)
      AC090480, AC151573
      Conserved Domains (1) summary
      pfam01529
      Location:126281
      DHHC; DHHC palmitoyltransferase
    8. NM_175160.5NP_780369.1  palmitoyltransferase ZDHHC1 isoform 1

      See identical proteins and their annotated locations for NP_780369.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1, 3, and 4 all encode the same isoform (1).
      Source sequence(s)
      AC090480, AC151573
      Consensus CDS
      CCDS22603.1
      UniProtKB/Swiss-Prot
      Q0VE36, Q8BJ24, Q8R0N9
      Related
      ENSMUSP00000148381.2, ENSMUST00000212303.2
      Conserved Domains (1) summary
      pfam01529
      Location:126281
      DHHC; DHHC palmitoyltransferase

    RNA

    1. NR_166407.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC090480, AC151573
    2. NR_166408.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC090480, AC151573
    3. NR_166409.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC090480, AC151573

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      106199055..106223694 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)