Snai3 snail family zinc finger 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Snai3provided by MGI
Official Full Name: snail family zinc finger 3provided by MGI
Primary source: MGI:MGI:1353563
See related: Ensembl:ENSMUSG00000006587 AllianceGenome:MGI:1353563
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Smuc; Zfp293
Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including 1st branchial arch; genitourinary system; hemolymphoid system gland; hepatic primordium; and lung. Orthologous to human SNAI3 (snail family transcriptional repressor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in thymus adult (RPKM 15.7), mammary gland adult (RPKM 3.0) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 E1; 8 71.07 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (123180943..123187546, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (122454204..122460809, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that expression of SNAI3 in ovary is reduced during ovulation, after which it increases gradually during luteinization. During early embryo cleavage, SNAI3 is localized to nucleus, except nucleolus at germinal vesicle and one-cell stages.
Title: Expression and distribution of the zinc finger protein, SNAI3, in mouse ovaries and pre-implantation embryos.
using global gene expression analysis of partially reprogrammed cells, we identified SNAI3 as a novel invasion-related marker in human melanoma. SNAI3 expression correlates with tumor thickness in primary melanomas and thus, may be of prognostic value
Title: Directed Dedifferentiation Using Partial Reprogramming Induces Invasive Phenotype in Melanoma Cells.
The data presented here demonstrate that Snai2 and Snai3 transcriptionally regulate the cellular fitness and functionality of not only CD4(+) regulatory T cells but effector CD8(alpha+) and CD4(+) conventional T cells as well.
Title: Snai2 and Snai3 transcriptionally regulate cellular fitness and functionality of T cell lineages through distinct gene programs.
Data indicate that deletion of snail family transcription factors Snai2 and Snai3 in bone marrow-derived cells is sufficient to induce autoantibody generation.
Title: Fatal autoimmunity results from the conditional deletion of Snai2 and Snai3.
Deletion of Snai2 and Snai3 results in impaired physical development compounded by lymphocyte deficiency.
Title: Deletion of Snai2 and Snai3 results in impaired physical development compounded by lymphocyte deficiency.
Snai3 gene function is not essential for embryogenesis in mice.
Title: The snail family gene snai3 is not essential for embryogenesis in mice.
overexpression of Snai3 does alter bone marrow cell development
Title: Overexpression of Snai3 suppresses lymphoid- and enhances myeloid-cell differentiation.
Expression of Snai3 was studied during mouse development.
Title: Expression of the novel Snai-related zinc-finger transcription factor gene Smuc during mouse development.
Snail is present in activated mesenchymal cells indicating its relevance in the communication between tumor and stroma and suggest that it can promote the conversion of carcinoma cells to stromal cells.
Title: Expression of Snail protein in tumor-stroma interface.
These data implicate Smuc as blocking Pactolus transcription in cells expressing PU.1 (and CD18) but not Pactolus.
Title: Transcriptional control of Pactolus: evidence of a negative control region and comparison with its evolutionary paralogue, CD18 (beta2 integrin).

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (7) 1 citation
Endonuclease-mediated (3)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:485241

AI643946 (e-PCR)
- UniSTS:179839

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: zinc finger protein SNAI3

Names: protein snail homolog 3; snail homolog 3; snail-related gene from muscle cells; snail-related protein 2; zinc finger protein 293

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013914.3 → NP_038942.1 zinc finger protein SNAI3

See identical proteins and their annotated locations for NP_038942.1

Status: VALIDATED

Source sequence(s)

AC114917

Consensus CDS

CCDS22739.1

UniProtKB/Swiss-Prot

Q3U3U2, Q496S5, Q8C244, Q9QY31

Related

ENSMUSP00000006762.6, ENSMUST00000006762.7

Conserved Domains (3) summary

COG5048
Location:209 → 254

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:206 → 226

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:219 → 242

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

123180943..123187546 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006531074.5 → XP_006531137.1 zinc finger protein SNAI3 isoform X1

Conserved Domains (3) summary

sd00017
Location:180 → 200

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:232 → 254

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:219 → 242

zf-H2C2_2; Zinc-finger double domain