U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Cops5 COP9 signalosome subunit 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312916, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Cops5provided by RGD
    Official Full Name
    COP9 signalosome subunit 5provided by RGD
    Primary source
    RGD:1310301
    See related
    Ensembl:ENSRNOG00000006499 AllianceGenome:RGD:1310301
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable enzyme binding activity; macrophage migration inhibitory factor binding activity; and peptidase activity. Predicted to be involved in several processes, including protein modification by small protein removal; regulation of cellular response to stress; and regulation of transcription, DNA-templated. Predicted to act upstream of or within regulation of cell cycle. Predicted to be located in several cellular components, including nucleoplasm; perinuclear region of cytoplasm; and synaptic vesicle. Predicted to be part of COP9 signalosome. Predicted to be active in cytoplasm. Predicted to colocalize with chromatin. Orthologous to human COPS5 (COP9 signalosome subunit 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 529.0), Testes (RPKM 471.8) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    5q11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (13975198..13993391)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (9192233..9210498)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (8876090..8894345)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ADP ribosylation factor guanine nucleotide exchange factor 1 Neighboring gene uncharacterized LOC134486914 Neighboring gene uncharacterized LOC134486913 Neighboring gene centrosome and spindle pole associated protein 1 Neighboring gene RNA, U6 small nuclear 1297 Neighboring gene protein phosphatase 1, regulatory subunit 42

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Porcine JAB1 significantly enhances apoptosis induced by staurosporine. Jiang P, et al. Cell Death Dis, 2013 Oct 3. PMID 24091666, Free PMC Article
    2. COP9-associated CSN5 regulates exosomal protein deubiquitination and sorting. Liu Y, et al. Am J Pathol, 2009 Apr. PMID 19246649, Free PMC Article
    3. Down-regulation of the cyclin-dependent kinase inhibitor p57 is mediated by Jab1/Csn5 in hepatocarcinogenesis. Guo H, et al. Hepatology, 2016 Mar. PMID 26606000
    4. Fank1 interacts with Jab1 and regulates cell apoptosis via the AP-1 pathway. Wang H, et al. Cell Mol Life Sci, 2011 Jun. PMID 20978819
    5. RIG-G as a key mediator of the antiproliferative activity of interferon-related pathways through enhancing p21 and p27 proteins. Xiao S, et al. Proc Natl Acad Sci U S A, 2006 Oct 31. PMID 17050680, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Jab1 provides a novel signal transduction pathway for 5-HT(6)R and may play an important role in 5-HT(6)R-mediated behavior changes in the brain
      Title: Physical interaction of Jab1 with human serotonin 6 G-protein-coupled receptor and their possible roles in cell survival.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC112728

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables deNEDDylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables macrophage migration inhibitory factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal-dependent deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metallopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in exosomal secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein deneddylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein deneddylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of IRE1-mediated unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of COP9 signalosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COP9 signalosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    COP9 signalosome complex subunit 5
    Names
    COP9 (constitutive photomorphogenic) homolog, subunit 5

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025695.1 → NP_001020866.1  COP9 signalosome complex subunit 5

      See identical proteins and their annotated locations for NP_001020866.1

      Status: PROVISIONAL

      Source sequence(s)
      BC098736
      UniProtKB/TrEMBL
      A0A8I5ZYE7, Q4KM69
      Related
      ENSRNOP00000008877.5, ENSRNOT00000008877.7
      Conserved Domains (1) summary
      cd08069
      Location:44 → 314
      MPN_RPN11_CSN5; Mov34/MPN/PAD-1 family: proteasomal regulatory protein Rpn11 and signalosome complex subunit CSN5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      13975198..13993391
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006237758.5 → XP_006237820.1  COP9 signalosome complex subunit 5 isoform X1

      Conserved Domains (1) summary
      cd08069
      Location:33 → 297
      MPN_RPN11_CSN5; Mov34/MPN/PAD-1 family: proteasomal regulatory protein Rpn11 and signalosome complex subunit CSN5
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous