Tmem109 transmembrane protein 109 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tmem109provided by RGD
Official Full Name: transmembrane protein 109provided by RGD
Primary source: RGD:1359538
See related: Ensembl:ENSRNOG00000028017 AllianceGenome:RGD:1359538
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable voltage-gated ion channel activity. Predicted to be involved in cellular response to gamma radiation; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; and negative regulation of cell death. Predicted to be located in nuclear outer membrane and sarcoplasmic reticulum membrane. Predicted to be integral component of membrane. Orthologous to human TMEM109 (transmembrane protein 109). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 798.5), Lung (RPKM 452.0) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (216944516..216955091, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (207519628..207530245, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (226925114..226935710, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data, including data from studies in vesicles of knockout mice, suggest pathophysiological levels of Zn2+ (>2nM) cause dysregulation of RyR2 opening; in sarcoplasmic reticulum, RyR2 are not the only Ca2+-channels regulated by Zn2+; in cardiomyocytes exposed to ischemic/hypoxic conditions, intracellular Zn2+ levels are elevated, coinciding with increased MG23 expression. (RyR2 = ryanodine receptor 2; MG23 = mitsugumin 23)
Title: Dysregulated Zn(2+) homeostasis impairs cardiac type-2 ryanodine receptor and mitsugumin 23 functions, leading to sarcoplasmic reticulum Ca(2+) leakage.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables voltage-gated monoatomic cation channel activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cellular response to gamma radiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to gamma radiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to gamma radiation	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IBA Inferred from Biological aspect of Ancestor more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in monoatomic cation transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of programmed cell death	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of programmed cell death	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
located_in nuclear outer membrane	IEA Inferred from Electronic Annotation more info
located_in sarcoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: voltage-gated monoatomic cation channel TMEM109

Names: mg23; mitsugumin-23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007736.1 → NP_001007737.1 voltage-gated monoatomic cation channel TMEM109 precursor

See identical proteins and their annotated locations for NP_001007737.1

Status: PROVISIONAL

Source sequence(s)

BC078955

UniProtKB/Swiss-Prot

Q6AYQ4

UniProtKB/TrEMBL

A0A8L2QIK0, A6I065

Related

ENSRNOP00000036054.4, ENSRNOT00000038807.6

Conserved Domains (1) summary

pfam14965
Location:57 → 231

BRI3BP; Negative regulator of p53/TP53

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

216944516..216955091 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006231059.5 → XP_006231121.1 voltage-gated monoatomic cation channel TMEM109 isoform X2

See identical proteins and their annotated locations for XP_006231121.1

UniProtKB/Swiss-Prot

Q6AYQ4

UniProtKB/TrEMBL

A0A8L2QIK0, A6I065

Conserved Domains (1) summary

pfam14965
Location:57 → 231

BRI3BP; Negative regulator of p53/TP53
XM_039084262.2 → XP_038940190.1 voltage-gated monoatomic cation channel TMEM109 isoform X1

UniProtKB/TrEMBL

A0A8L2QIK0

Conserved Domains (1) summary

pfam14965
Location:64 → 238

BRI3BP; Negative regulator of p53/TP53