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    Gcsam germinal center associated, signaling and motility [ Mus musculus (house mouse) ]

    Gene ID: 14525, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Gcsamprovided by MGI
    Official Full Name
    germinal center associated, signaling and motilityprovided by MGI
    Primary source
    MGI:MGI:102969
    See related
    Ensembl:ENSMUSG00000022659 AllianceGenome:MGI:102969
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    M17; Gcet; Gcet2; M17-L
    Summary
    Predicted to enable actin binding activity; myosin II binding activity; and protein kinase binding activity. Predicted to be involved in negative regulation of lymphocyte migration and regulation of B cell receptor signaling pathway. Predicted to be located in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and integumental system. Orthologous to human GCSAM (germinal center associated signaling and motility). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Gcsam in Genome Data Viewer
    Location:
    16 29.72 cM; 16 B5
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (45430803..45443230)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (45610440..45622867)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene TNF receptor associated factor 4 pseudogene Neighboring gene solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1 Neighboring gene cDNA sequence, BC016579 Neighboring gene transmembrane serine protease 7 Neighboring gene STARR-seq mESC enhancer starr_40918 Neighboring gene STARR-seq mESC enhancer starr_40919

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. M17: a novel gene expressed in germinal centers. Christoph T, et al. Int Immunol, 1994 Aug. PMID 7981148
    2. Identification of an Sp factor-dependent promoter in GCET, a gene expressed at high levels in germinal center B cells. Steinke JW, et al. Mol Immunol, 2004 Nov. PMID 15482850
    3. Protocol for using signal peptide differential display and representational difference analysis to isolate differentially expressed cDNAs from fetal mouse brain. Eriksson A, et al. Brain Res Brain Res Protoc, 2001 Feb. PMID 11223410
    4. M17, a gene specific for germinal center (GC) B cells and a prognostic marker for GC B-cell lymphomas, is dispensable for the GC reaction in mice. Schenten D, et al. Blood, 2006 Jun 15. PMID 16493007, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Assays identified a non-consensus binding site for Sp factors near sites of transcriptional initiation. The site binds Spl and Sp3 in nuclear extracts.
      Title: Identification of an Sp factor-dependent promoter in GCET, a gene expressed at high levels in germinal center B cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables myosin II binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of lymphocyte migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of lymphocyte migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of B cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of B cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of lymphocyte migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    germinal center-associated signaling and motility protein
    Names
    germinal center B-cell-expressed transcript 2 protein
    germinal center expressed transcript 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159297.1 → NP_001152769.1  germinal center-associated signaling and motility protein isoform 1

      See identical proteins and their annotated locations for NP_001152769.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      AK036553, AY500830, U13263
      Consensus CDS
      CCDS49861.1
      UniProtKB/Swiss-Prot
      Q60691, Q6RFH4, Q8CB90
      Related
      ENSMUSP00000123853.2, ENSMUST00000161347.9
      Conserved Domains (1) summary
      pfam15666
      Location:74 → 155
      HGAL; Germinal center-associated lymphoma

    2. NM_008099.4 → NP_032125.3  germinal center-associated signaling and motility protein isoform 2

      See identical proteins and their annotated locations for NP_032125.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This difference results in a protein (isoform 2) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK036553, U13263
      Consensus CDS
      CCDS28199.1
      UniProtKB/Swiss-Prot
      Q6RFH4
      Related
      ENSMUSP00000023339.5, ENSMUST00000023339.5
      Conserved Domains (1) summary
      pfam15666
      Location:52 → 133
      HGAL; Germinal center-associated lymphoma

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      45430803..45443230
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6RFH4.1 GenPept UniProtKB/Swiss-Prot:Q6RFH4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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