Papss2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Papss2provided by MGI
Official Full Name: 3'-phosphoadenosine 5'-phosphosulfate synthase 2provided by MGI
Primary source: MGI:MGI:1330223
See related: Ensembl:ENSMUSG00000024899 AllianceGenome:MGI:1330223
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: bm; Sk2; AtpsU2; Atpsk2; 1810018P12Rik
Summary: Enables adenylylsulfate kinase activity and sulfate adenylyltransferase (ATP) activity. Acts upstream of or within blood coagulation; bone development; and sulfate assimilation. Is expressed in several structures, including genitourinary system; heart; limb; sensory organ; and skeleton. Used to study spondyloepimetaphyseal dysplasia, Pakistani type. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia, Pakistani type. Orthologous to human PAPSS2 (3'-phosphoadenosine 5'-phosphosulfate synthase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in kidney adult (RPKM 50.1), small intestine adult (RPKM 40.8) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C1; 19 27.46 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (32573072..32644587)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (32595669..32667187)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Intestinal Sulfation Is Essential to Protect Against Colitis and Colonic Carcinogenesis.
Title: Intestinal Sulfation Is Essential to Protect Against Colitis and Colonic Carcinogenesis.
Genetic variants in SULT2A1, PAPSS2, and STS do not predispose to polycystic ovary syndrome.
Title: Variants in SULT2A1 affect the DHEA sulphate to DHEA ratio in patients with polycystic ovary syndrome but not the hyperandrogenic phenotype.
The results suggest that PAPSS2 might regulate osteoblast ALP activity and cell mineralization, probably through Smads signal pathways.
Title: PAPSS2 promotes alkaline phosphates activity and mineralization of osteoblastic MC3T3-E1 cells by crosstalk and Smads signal pathways.
hypertrophic chondrocytes show a dramatic down-regulation of Papss2 mRNA expression, indicating an important role of the gene product for cartilage growth and development in the embryo
Title: Expression profile of Papss2 (3'-phosphoadenosine 5'-phosphosulfate synthase 2) during cartilage formation and skeletal development in the mouse embryo.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Spontaneous (1) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

D0M19Mit13 (e-PCR)
- UniSTS:128344

D19Mit13 (e-PCR), detects polymorphism
- UniSTS:128344

Papss2 (e-PCR), detects polymorphism
- UniSTS:502687

Papss2 (e-PCR), detects polymorphism
- UniSTS:502688

Papss2 (e-PCR), detects polymorphism
- UniSTS:498397

Papss2 (e-PCR), detects polymorphism
- UniSTS:498398

AI159688 (e-PCR)
- UniSTS:181220

Papss2 (e-PCR), detects polymorphism
- UniSTS:144122

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables adenylylsulfate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenylylsulfate kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables adenylylsulfate kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables sulfate adenylyltransferase (ATP) activity	IDA Inferred from Direct Assay more info	PubMed
enables sulfate adenylyltransferase (ATP) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood coagulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within bone development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hormone metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in sulfate assimilation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sulfate assimilation	IDA Inferred from Direct Assay more info	PubMed
involved_in sulfate assimilation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2

Names: PAPS synthase 2; brachymorphic; sulfurylase kinase 2

NP_001188399.1

EC 2.7.1.25

EC 2.7.7.4

NP_001347332.1

EC 2.7.1.25

EC 2.7.7.4

NP_035994.2

EC 2.7.1.25

EC 2.7.7.4

XP_006527127.1

EC 2.7.1.25

EC 2.7.7.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001201470.1 → NP_001188399.1 bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC162887, AK137675, BY224664

Consensus CDS

CCDS89376.1

UniProtKB/TrEMBL

A0A494B923, Q9QYS0

Related

ENSMUSP00000157455.2, ENSMUST00000235594.2

Conserved Domains (3) summary

cd00517
Location:243 → 606

ATPS; ATP-sulfurylase

cd02027
Location:43 → 193

APSK; Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form important for the assimilation of ...

TIGR00339
Location:234 → 605

sopT; ATP sulphurylase
NM_001360403.1 → NP_001347332.1 bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC162887

Consensus CDS

CCDS89377.1

UniProtKB/TrEMBL

A0A494BB18, Q9QYS0

Related

ENSMUSP00000158330.2, ENSMUST00000236290.2

Conserved Domains (2) summary

cd00517
Location:245 → 608

ATPS; ATP-sulfurylase

cd02027
Location:45 → 195

APSK; Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form important for the assimilation of ...
NM_011864.3 → NP_035994.2 bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform 1

See identical proteins and their annotated locations for NP_035994.2

Status: VALIDATED

Source sequence(s)

AC162887

Consensus CDS

CCDS37960.1

UniProtKB/Swiss-Prot

O88428, Q5BKP4, Q9Z274

UniProtKB/TrEMBL

Q9QYS0

Related

ENSMUSP00000025833.7, ENSMUST00000025833.7

Conserved Domains (3) summary

cd00517
Location:245 → 613

ATPS; ATP-sulfurylase

cd02027
Location:45 → 195

APSK; Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form important for the assimilation of ...

TIGR00339
Location:236 → 612

sopT; ATP sulphurylase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

32573072..32644587

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006527064.5 → XP_006527127.1 bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1

UniProtKB/TrEMBL

Q9QYS0

Conserved Domains (2) summary

cd00517
Location:243 → 611

ATPS; ATP-sulfurylase

cd02027
Location:43 → 193

APSK; Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form important for the assimilation of ...