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    Pi16 peptidase inhibitor 16 [ Mus musculus (house mouse) ]

    Gene ID: 74116, updated on 21-Apr-2024

    Summary

    Official Symbol
    Pi16provided by MGI
    Official Full Name
    peptidase inhibitor 16provided by MGI
    Primary source
    MGI:MGI:1921366
    See related
    Ensembl:ENSMUSG00000024011 AllianceGenome:MGI:1921366
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cripi; PI-16; 1200009H11Rik
    Summary
    Predicted to enable peptidase inhibitor activity. Acts upstream of or within negative regulation of cell growth involved in cardiac muscle cell development. Located in extracellular space. Is expressed in cranial ganglion; dorsal root ganglion; medulla oblongata basal plate mantle layer; and neural retina. Orthologous to human PI16 (peptidase inhibitor 16). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in bladder adult (RPKM 160.4), mammary gland adult (RPKM 72.5) and 6 other tissues See more
    Orthologs
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    Genomic context

    Location:
    17 A3.3; 17 15.22 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (29537770..29547876)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (29318796..29328903)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene cDNA sequence BC004004 Neighboring gene predicted gene, 53222 Neighboring gene predicted pseudogene 10045 Neighboring gene predicted gene, 46603 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:29469332-29469441 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:29475389-29475661 Neighboring gene mitochondrial carrier 1 Neighboring gene STARR-positive B cell enhancer ABC_E4202 Neighboring gene STARR-positive B cell enhancer ABC_E5586 Neighboring gene STARR-positive B cell enhancer ABC_E7508 Neighboring gene FYVE, RhoGEF and PH domain containing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1)  1 citation
    • Endonuclease-mediated (4) 

    General protein information

    Preferred Names
    peptidase inhibitor 16
    Names
    cysteine-rich protease inhibitor
    protease inhibitor 16

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023734.3NP_076223.3  peptidase inhibitor 16 precursor

      Status: VALIDATED

      Source sequence(s)
      AB046537, AI587910, AK157854
      Consensus CDS
      CCDS28595.2
      UniProtKB/Swiss-Prot
      Q148Q6, Q8CHU4, Q9ET66, Q9JJ56
      Related
      ENSMUSP00000110349.3, ENSMUST00000114701.10
      Conserved Domains (1) summary
      cd05559
      Location:35168
      SCP_HrTT-1; SCP_HrTT-1: SCP-like extracellular protein domain in HrTT-1, a tail-tip epidermis marker in ascidians. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      29537770..29547876
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525014.2XP_006525077.1  peptidase inhibitor 16 isoform X1

      UniProtKB/TrEMBL
      D3Z6T6
      Related
      ENSMUSP00000116183.3, ENSMUST00000155348.3
      Conserved Domains (1) summary
      cd05559
      Location:35168
      CAP_PI16_HrTT-1; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of peptidase inhibitor 16 and HrTT-1 protein