Socs5 suppressor of cytokine signaling 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Socs5provided by MGI
Official Full Name: suppressor of cytokine signaling 5provided by MGI
Primary source: MGI:MGI:2385459
See related: Ensembl:ENSMUSG00000037104 AllianceGenome:MGI:2385459
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cish5; mKIAA0671; 1810018L08Rik
Summary: Enables epidermal growth factor receptor binding activity. Involved in several processes, including cellular response to low-density lipoprotein particle stimulus; negative regulation of cytokine production; and regulation of T-helper cell differentiation. Acts upstream of or within epidermal growth factor receptor signaling pathway. Predicted to be part of phosphatidylinositol 3-kinase complex. Is expressed in retina. Orthologous to human SOCS5 (suppressor of cytokine signaling 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 14.1), cortex adult (RPKM 11.1) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 E4; 17 56.93 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (87414707..87445153)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (87107278..87137647)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SOCS5, targeted by miR-155-5p, plays a negative regulatory role in pulmonary hypertension through inhibiting JAK2/STAT3 signaling pathway.
Title: SOCS5, targeted by miR-155-5p, plays a negative regulatory role in pulmonary hypertension through inhibiting JAK2/STAT3 signaling pathway.
Sequential inspiratory muscle exercise-noninvasive positive pressure ventilation alleviates oxidative stress in COPD by mediating SOCS5/JAK2/STAT3 pathway.
Title: Sequential inspiratory muscle exercise-noninvasive positive pressure ventilation alleviates oxidative stress in COPD by mediating SOCS5/JAK2/STAT3 pathway.
Suppressor of Cytokine Signalling 5 (SOCS5) Modulates Inflammatory Responses during Alphavirus Infection.
Title: Suppressor of Cytokine Signalling 5 (SOCS5) Modulates Inflammatory Responses during Alphavirus Infection.
Data show that the Japanese encephalitis virus (JEV)-induced expression of miR-301a led to inhibition of the production of the transcription factor IFN regulatory factor 1 (IRF1) and the signaling protein suppressor of cytokine signaling 5 (SOCS5).
Title: The host microRNA miR-301a blocks the IRF1-mediated neuronal innate immune response to Japanese encephalitis virus infection.
this study shows that DRD3 signaling evokes Socs5 expression, a negative regulator of Th2 development, which indirectly favors acquisition of Th1 phenotype
Title: Dopamine Receptor D3 Signaling on CD4+ T Cells Favors Th1- and Th17-Mediated Immunity.
have identified a phosphorylation site (Ser211) within the JIR of mSOCS5 and have investigated the role of phosphorylation in modulating JAK binding using site-directed mutagenesis.
Title: Structure and Functional Characterization of the Conserved JAK Interaction Region in the Intrinsically Disordered N-Terminus of SOCS5.
Identified is a conserved region of about 70 residues in the N-terminal domains of Socs4 and 5 that is predicted to be more ordered than the surrounding sequence.
Title: The N-terminal domains of SOCS proteins: a conserved region in the disordered N-termini of SOCS4 and 5.
The effect of Flt3-L on Th17 cells and expression of suppressors of cytokine signaling (SOCS) proteins in the lungs of house dust mite (HDM)-sensitized and -challenged mice, was evaluated.
Title: Fms-like tyrosine kinase 3 ligand decreases T helper type 17 cells and suppressors of cytokine signaling proteins in the lung of house dust mite-sensitized and -challenged mice.
SOCS5-deficient CD4 T cells showed no abnormalities in Th1/Th2 differentiation and Socs5(-/-) mice showed normal resistance to infection with Leishmania major.
Title: SOCS5 is expressed in primary B and T lymphoid cells but is dispensable for lymphocyte production and function.
SOCS-5 associated with the EGF-R complex in an EGF-independent manner
Title: Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124335 (e-PCR)
- UniSTS:161157

NoName (e-PCR)
- UniSTS:237723

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables epidermal growth factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinase inhibitor activity	NAS Non-traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor tyrosine kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to low-density lipoprotein particle stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytokine-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within epidermal growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of T-helper 2 cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of endothelial cell activation	IC Inferred by Curator more info	PubMed
involved_in negative regulation of epidermal growth factor-activated receptor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of monocyte chemotactic protein-1 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of signal transduction	NAS Non-traceable Author Statement more info	PubMed
involved_in phosphatidylinositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T-helper 1 cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in vascular endothelial cell response to fluid shear stress	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	NAS Non-traceable Author Statement more info	PubMed
part_of phosphatidylinositol 3-kinase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: suppressor of cytokine signaling 5

Names: SOCS-5; cytokine inducible SH2-containing protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019654.2 → NP_062628.2 suppressor of cytokine signaling 5

See identical proteins and their annotated locations for NP_062628.2

Status: PROVISIONAL

Source sequence(s)

BC053015

Consensus CDS

CCDS29014.1

UniProtKB/Swiss-Prot

O54928, Q7TSK1

Related

ENSMUSP00000038591.7, ENSMUST00000041369.8

Conserved Domains (3) summary

cd03739
Location:479 → 534

SOCS_SOCS5; SOCS (suppressors of cytokine signaling) box of SOCS5-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS5 inhibits Th2 differentiation by inhibiting ...

pfam12610
Location:146 → 195

SOCS; Suppressor of cytokine signalling

cl15255
Location:370 → 470

SH2; Src homology 2 (SH2) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

87414707..87445153

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006524674.5 → XP_006524737.1 suppressor of cytokine signaling 5 isoform X1

See identical proteins and their annotated locations for XP_006524737.1

UniProtKB/Swiss-Prot

O54928, Q7TSK1

Conserved Domains (3) summary

cd03739
Location:479 → 534

SOCS_SOCS5; SOCS (suppressors of cytokine signaling) box of SOCS5-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS5 inhibits Th2 differentiation by inhibiting ...

pfam12610
Location:146 → 195

SOCS; Suppressor of cytokine signalling

cl15255
Location:370 → 470

SH2; Src homology 2 (SH2) domain
XM_006524671.5 → XP_006524734.1 suppressor of cytokine signaling 5 isoform X1

See identical proteins and their annotated locations for XP_006524734.1

UniProtKB/Swiss-Prot

O54928, Q7TSK1

Conserved Domains (3) summary

cd03739
Location:479 → 534

SOCS_SOCS5; SOCS (suppressors of cytokine signaling) box of SOCS5-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS5 inhibits Th2 differentiation by inhibiting ...

pfam12610
Location:146 → 195

SOCS; Suppressor of cytokine signalling

cl15255
Location:370 → 470

SH2; Src homology 2 (SH2) domain
XM_006524672.5 → XP_006524735.1 suppressor of cytokine signaling 5 isoform X1

See identical proteins and their annotated locations for XP_006524735.1

UniProtKB/Swiss-Prot

O54928, Q7TSK1

Conserved Domains (3) summary

cd03739
Location:479 → 534

SOCS_SOCS5; SOCS (suppressors of cytokine signaling) box of SOCS5-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS5 inhibits Th2 differentiation by inhibiting ...

pfam12610
Location:146 → 195

SOCS; Suppressor of cytokine signalling

cl15255
Location:370 → 470

SH2; Src homology 2 (SH2) domain
XM_006524675.5 → XP_006524738.1 suppressor of cytokine signaling 5 isoform X1

See identical proteins and their annotated locations for XP_006524738.1

UniProtKB/Swiss-Prot

O54928, Q7TSK1

Conserved Domains (3) summary

cd03739
Location:479 → 534

SOCS_SOCS5; SOCS (suppressors of cytokine signaling) box of SOCS5-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS5 inhibits Th2 differentiation by inhibiting ...

pfam12610
Location:146 → 195

SOCS; Suppressor of cytokine signalling

cl15255
Location:370 → 470

SH2; Src homology 2 (SH2) domain